Bottom Line: Patients whose acute myelogenous leukemia (AML) had relapsed or was resistant to chemotherapy and those who were deemed unable to tolerate chemotherapy experienced responses to the selective BCL-2 inhibitor venetoclax (Venclexta), with complete remissions in some, according to phase II clinical trial data.
Journal in Which the Study was Published: Cancer Discovery, a journal of the American Association for Cancer Research.
The amines are one of the most important classes of chemical compounds today. Amines that contain a ring-like structure - called an "aryl" group - are used widely in pharmaceuticals, such as the top-selling drugs Abilify, Crestor, Gleevec, and Lidoderm. EPFL scientists have now developed a method to produce aryl-containing amines in a cheap and easily scalable way. The work is published in Nature Communications.
Intestinal flora has multiple influences on human health, but researchers have revealed that it is also likely to have an effect on the body's response to drugs. Recent research from Kumamoto University in Japan strongly suggests that changes in the intestinal flora, caused by antibacterial and antibiotic drugs or individual differences between people, may have an effect on a person's response to drugs including side effects. The research focused on the changes in proteins due to the condition of intestinal flora that affect the response to drugs in the liver and kidneys.
SAN FRANCISCO (August 10, 2016) -- Scientists have discovered a new species of colorful songbird in the Galápagos Islands, with one catch: it's extinct.
Unique optical features of quantum dots make them an attractive tool for many applications, from cutting-edge displays to medical imaging. Physical, chemical or biological properties of quantum dots must, however, be adapted to the desired needs. Unfortunately, up to now quantum dots prepared by chemical methods could be functionalized using copper-based click reactions with retention of their luminescence. This obstacle can be ascribed to the fact that copper ions destroy the ability of quantum dots to emit light.
The detonation of atomic bombs over the Japanese cities of Hiroshima and Nagasaki in August 1945 resulted in horrific casualties and devastation. The long-term effects of radiation exposure also increased cancer rates in the survivors. But public perception of the rates of cancer and birth defects among survivors and their children is in fact greatly exaggerated when compared to the reality revealed by comprehensive follow-up studies.
Although corn and soybeans do not need insects for pollination, they do offer floral resources that are used by insect pollinators. So what kind of insects are commonly found in corn and soybean fields? The answer to that question can be found in a new article published in Environmental Entomology.
Plant species that have evolved to withstand elevated levels of carbon dioxide grow poorly when moved to a plant community with a different make up, according to a new study in Nature Communications.
"In an effort to save certain species, there has been an interest in the movement of plants or animals to more climatically suitable habitats," said University of British Columbia ecologist Elizabeth Kleynhans, lead author of the study. "Our research indicates how one species adapts in one community may not transfer to other communities."
Since the 1970s, sexual assault hotlines have grown in popularity in North America as conduits for survivors, their loved ones and professionals to unite for immediate support. Today, there are more than 1,000 crisis hotline affiliates in the United States alone. Yet, despite their widespread use, much remains unknown or unclear about their service efficacy.
A new study that for the first time examined the internal anatomy of a fossil human relative's heel bone, or calcaneus, shows greater similarities with gorillas than chimpanzees.
The study, titled: Trabecular architecture in the StW 352 fossil hominin calcaneus and published in the Journal of Human Evolution, was undertaken by a team of international researchers from the University of the Witwatersrand in South Africa, Duke University, University of Southern California and Indiana University in the US.
Archaeologists from the Universities of York, Cambridge and UCL have identified rare human bones from the UK dating to the Late Mesolithic era (around 4000 BC, just prior to the arrival of farming in Britain) using an innovative new bone collagen analysis technique.
Surprisingly, there is a near absence of human remains in Britain from this period. However, a small island in the Inner Hebrides - Oronsay - is unique as it holds the remains of six human individuals.
The Insect Biogeography and Biodiversity research group led by Dr Benoit Guénard at the School of Biological Sciences, the University of Hong Kong (HKU) has recently described and named a new species of ant from Hong Kong, Paratopula bauhinia, or the rare "Golden Tree Ant" in Asian Myrmecology, a peer-reviewed, yearly journal dedicated to the study of Asian ants.
Aug. 10, 2016--Reducing outdoor concentrations of two air pollutants, ozone (O3) and fine particulate matter (PM2.5), to levels below those set by the U.S.
Wine growers and nurseries would benefit from detecting the dangerous crown gall disease in their vines before it breaks out. Such an early diagnosis is not available at present and cannot be expected soon.
This conclusion is drawn by Dr. Rosalia Deeken from the Biocenter of the Julius-Maximilians-Universität Würzburg (JMU) in Bavaria, Germany, and Professor Ute Hentschel-Humeida who worked here before relocating to Kiel. The scientists are convinced that the currently available methods are incapable of diagnosing crown gall disease reliably at an early stage.
The established theory about the route by which Ice Age peoples first reached the present-day United States has been challenged by an unprecedented study which concludes that their supposed entry route was "biologically unviable".
The first people to reach the Americas crossed via an ancient land bridge between Siberia and Alaska but then, according to conventional wisdom, had to wait until two huge ice sheets that covered what is now Canada started to recede, creating the so-called "ice-free corridor" which enabled them to move south.