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Pneumonia-causing bacteria can be spread through picking and rubbing the nose, according to new research published in the European Respiratory Journal [1].

Pneumococcus, the bacteria that can cause pneumonia, is known to be spread through inhalation of airborne droplets containing the bacteria, for example in coughs and sneezes. This study is the first to show that transmission can also occur via contact between the nose and the hands after exposure to pneumococcus bacteria.

A new study has found that the Rehabilitation Enablement in CHronic Heart Failure (REACH-HF) programme, led by the University of Exeter and the Royal Cornwall Hospitals NHS trust, significantly improved quality of life and is deliverable within NHS cost guidelines.

Scientists from Tartu have discovered a simple way how to improve infertility treatment in the future. The results of the study, published in Human Reproduction, a top journal in the field, can be used in precision medicine to account for the variability in each female patient's menstrual cycle. This personalised approach will first and foremost benefit those couples, who have experienced repeated IVF failure.

Ever wonder why things that normally feel gentle, like putting on soft shirts, are painful after a sunburn? In a study of four patients with a rare genetic disorder, NIH researchers found that PIEZO2, a gene previously shown to control our sense of our bodies in space and gentle touch, may also be responsible for tactile allodynia: the skin's reaction to injury that makes normally gentle touches feel painful.

Higher levels of biomarkers of dairy fat consumption are associated with a lower risk of developing type 2 diabetes, according to new research published today in PLOS Medicine. The study, in more than 60,000 adults, was undertaken by an international consortium led by scientists at the Medical Research Council Epidemiology Unit, University of Cambridge, and the Friedman School of Nutrition Science and Policy at Tufts University.

CAMBRIDGE, Mass. -- A class exercise at MIT, aided by industry researchers, has led to an innovative solution to one of the longstanding challenges facing the development of practical fusion power plants: how to get rid of excess heat that would cause structural damage to the plant.

Planned intermittent fasting may help to reverse type 2 diabetes, suggest doctors writing in the journal BMJ Case Reports after three patients in their care, who did this, were able to cut out the need for insulin treatment altogether.

Around one in 10 people in the US and Canada have type 2 diabetes, which is associated with other serious illness and early death. It is thought to cost the US economy alone US$245 billion a year.

Annals of Internal Medicine Tip Sheet

Below please find summaries of new articles that will be published in the next issue of Annals of Internal Medicine. The summaries are not intended to substitute for the full articles as a source of information.

1. Evidence does not support statin use for conditions other than heart disease

Abstract: http://annals.org/aim/article/doi/10.7326/M18-0808
URLs go live when the embargo lifts

Refugee and immigrant youth in Ontario may face barriers to accessing mental health services through primary care, say the authors of a study of emergency department visits published in CMAJ (Canadian Medical Association Journal).

Toddlers with asthma are more likely to become obese children, according to an international study led by USC scientists.

For the first time, scientists have performed prenatal gene editing to prevent a lethal metabolic disorder in laboratory animals, offering the potential to treat human congenital diseases before birth.

Philadelphia, Oct. 8, 2018--For the first time, scientists have performed prenatal gene editing to prevent a lethal metabolic disorder in laboratory animals, offering the potential to treat human congenital diseases before birth. Published today in Nature Medicine, research from the Perelman School of Medicine at the University of Pennsylvania and the Children's Hospital of Philadelphia (CHOP) and offers proof-of-concept for prenatal use of a sophisticated, low-toxicity tool that efficiently edits DNA building blocks in disease-causing genes.

PHILADELPHIA - A new method for sequencing the chemical groups attached to the surface of DNA is paving the way for better detection of cancer and other diseases in the blood, according to research from the Perelman School of Medicine at the University of Pennsylvania published today in Nature Biotechnology. These chemical groups mark one of the four DNA "letters" in the genome, and it is differences in these marks along DNA that control which genes are expressed or silenced.

Combination checkpoint blockade before surgery (neoadjuvant therapy) produced a high response rate among patients with high-risk stage 3 melanoma, with nearly half having no sign of disease at surgery, but a high incidence of side effects caused the trial to be closed early.

The phase II study was led by researchers at The University of Texas MD Anderson Cancer Center. Results of the study, the first randomized neoadjuvant clinical trial of immune checkpoint blockade for melanoma patients, are reported in Nature Medicine.