Body
Bottom Line: The new, nonlive shingles vaccine reduced the occurrence of shingles (herpes zoster) compared with placebo among patients who had undergone stem cell transplantation with their own stem cells. Shingles risk is increased after this type of stem cell transplantation and a vaccine that contains a weakened live strain of the shingles virus isn't recommended for these immunocompromised patients.
Kidney diseases affect 850 million people worldwide, a figure twice as high as that of diabetes. Yet patients with chronic kidney disease (CKD) are still being excluded from clinical trials. This gives rise to severe problems, because many beneficial therapies cannot be authorised by regulatory authorities for this subgroup of patient, this means that the therapies in question cannot be prescribed for CKD patients. It is crucial, however, that CKD patients be eligible for new treatments, especially in the fields of diabetes, cardiovascular disease, cancer, and liver disease.
The power and convenience of modern-day word-processing programs, like Microsoft Word, have revolutionized our daily tasks. Need to create a quick resume for a new job opportunity? Procrastinating on that final term paper due tomorrow? Even creating a quick grocery list- Most of us rely on word-processing programs as stewards of our written lives. The functionality is impressive and unlike its archaic predecessor, the type writer, just a few keystrokes can change, delete, or add words as the user desires.
Amsterdam, July 9, 2019 - Duchenne muscular dystrophy occurs in boys and is characterized by progressive muscle degeneration and weakness leading to a decline in respiratory function. Strategies to arrest this severe progressive deterioration are needed to extend lives and improve quality of life.
New findings show how a genetically aberrant, fused protein promotes a rare form of liver cancer in adolescents and young adults. The researchers also saw that a certain mix of drugs could target the fused protein and the enzymes that it recruits. In the lab, this drug combination slowed down the uncontrolled growth of cells carrying the liver cancer mutation.
While the potential treatment approach needs further testing in animal models and in cancerous human liver cells, the early results are encouraging. This preliminary research project was published in eLife.
DALLAS, July 9, 2019 -- Significantly more patients suffer cardiac arrests in U.S. hospitals each year than previously estimated, according to new research in Circulation: Cardiovascular Quality and Outcomes, an American Heart Association journal.
Cardiac arrest, which occurs when the heart malfunctions and stops beating, is not the same as a heart attack, which occurs when blood flow to the heart is blocked.
BINGHAMTON, N.Y. - The herb kratom is increasingly being used to manage pain and treat opioid addiction, but it's not safe to use as an herbal supplement, according to new research led by faculty at Binghamton University, State University of New York.
Kuwait has some of the highest rates of obesity and diabetes in the world, and scientists don't know why. This question was addressed by Dr. Max Goodson, Emeritus Professor at the Forsyth Institute.
Goodson is the principal investigator of a large-scale study that analyzed diet, salivary bacteria, salivary protein biomarkers, and salivary metabolites of 10-year-old Kuwaiti children. Researchers collected saliva samples from 94 children once in 2012 and again in 2014.
(Boston)--In an effort to address the opioid epidemic in new, safe and effective ways, increasing access to buprenorphine, without a prescription, could prove helpful for treating persons with opioid use disorder (OUD), according to a Viewpoint in this week's JAMA.
It is estimated that two million people in the U.S. struggle with OUD (approximately 130 die daily from an overdose) while only 20 to 40 percent receive medications such as buprenorphine, methadone and naltrexone to treat this disorder.
Opioids work against severe pain but the risks of side effects and addiction are high. In the USA alone, 26 people die every day from overdoses. Now researchers in an international collaboration have investigated how common opioid prescriptions are for osteoarthritis patients in Sweden. It emerged that every fourth patient was prescribed opioids at some point between November 2014 and October 2015.
Patients with bowel cancer who have stopped responding to a widely used targeted drug could benefit from immunotherapy, a major new study reveals.
Scientists found that bowel tumours which had initially responded to cetuximab before developing resistance became more visible to the immune system - potentially leaving them vulnerable to immunotherapies.
A phase II clinical trial has already begun to test the possible benefit of immunotherapy in patients who have stopped responding to cetuximab.
PITTSBURGH, July 8, 2019 - New research from the University of Pittsburgh and the U.S. Department of Veterans Affairs (VA) shows that dispensing a year's supply of birth control pills up front would support women's reproductive autonomy while also being cost effective.
It's an unforeseen side effect of the nation's opioid epidemic: Adolescent heroin users.
A USC study in the July 8 issue of JAMA Pediatrics shows that teens who use prescription opioids to get high are more likely to start using heroin by high school graduation.
The Developmental Origins of Health and Disease (DOHaD) hypothesis is supported by multiple human epidemiological studies and animal studies. It states that the nutritional environment in early life makes people susceptible to lifestyle-related diseases, such as obesity, diabetes and heart attack, as adults. Many of those diseases exhibit reduced mitochondrial metabolism in the tissues of the body.
A window film with a specially designed molecule could be capable of taking the edge off the worst midday heat and instead distributing it evenly from morning to evening. The molecule has the unique ability to capture energy from the sun's rays and release it later as heat. This is shown by researchers at Chalmers University of Technology, Sweden, in the scientific journal Advanced Science.