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DUARTE, Calif. -- City of Hope researchers have identified a potential combination targeted therapy for a deadly type of leukemia found in some infants, a population too young to receive full-blown chemotherapy.
Called "mixed lineage leukemia (MLL)-rearranged B cell acute lymphoblastic leukemia (B-ALL)," this blood cancer subtype comes with bleak health outcomes (overall survival rate is less than 50%), disease recurrence and development of resistance to existing therapies.
News from Annals of Internal Medicine: Organizations urge immediate action to prevent firearm-relate
The American College of Physicians (ACP) and the nation's leading physician and public health organizations called for policies to reduce firearms-related injuries and deaths in the U.S. in a new call-to-action, "Firearm-Related Injury and Death in the United States: A Call to Action from the Nation's Leading Physician and Public Health Professional Organizations," published today in the Annals of Internal Medicine.
Asbestos-related cancers include lung cancer and malignant mesothelioma (MM) for which there is no cure. Most patients with MM die within two years of diagnosis and despite the banning of asbestos in many countries MM related deaths are predicted to rise in both industrialised and developing countries.
A University of Technology Sydney (UTS) led pilot study found that the zeolite clinoptilolite reduced asbestos-induced cellular damage in cell lines (in vitro) and significantly reduced MM development in mouse models (in vivo).
Bottom Line: A nationwide population-based study in Taiwan suggests attention-deficit/hyperactivity disorder (ADHD) may be associated with a higher risk of death from injury causes, including suicide, unintentional injury and homicide. Although the risk of suicide-related death was higher in patients with ADHD than in those without, the absolute risk of death was low and suicide deaths were rare, with natural-cause deaths and unintentional injury deaths accounting for a higher number of deaths than suicide in the group of patients with ADHD.
What The Study Did: This randomized clinical trial compared a technology-enhanced community health nursing intervention that included text message medication reminders with standard care for female adolescents and young adults with pelvic inflammatory disease.
Authors: Maria Trent, M.D., M.P.H., of the Johns Hopkins University School of Medicine in Baltimore, is the corresponding author.
(doi:10.1001/jamanetworkopen.2019.8652)
Distinct markers in the blood of people with coeliac disease have been detected within a few hours of gluten being consumed.
The findings address a longstanding mystery about what drives the adverse reaction to gluten in coeliac disease and could lead to a world-first blood test for diagnosing the disease.
A potential blood-based test would be a vast improvement on the current approach which requires people to consume gluten for a number of weeks, and even months, for the testing to be accurate.
EAST LANSING, Mich. - Michigan State University researchers, in collaboration with the Van Andel Institute, have identified a combination of two gene mutations that is linked to endometrial cancer.
"More than 63,000 women are likely to be diagnosed with endometrial cancer this year, making it the most commonly identified type of gynecologic cancer," said Ronald Chandler, an assistant professor of obstetrics, gynecology and reproductive biology in the College of Human Medicine, who led the study.
Leesburg, VA, August 7, 2019--According to an ahead-of-print "Focus On" article published in the November issue of the American Journal of Roentgenology (AJR), collaborative research has not only standardized the definition of a complete imaging history, but also engineered systems to include supportive prompts in the order entry interface with a single keystroke--sustainably improving the quality of imaging histories, themselves.
BOSTON -- A paper published today in Science Translational Medicine describes a simple, minimally invasive new tool for viewing differences in the nasal airways of cystic fibrosis patients in vivo at a cellular level. The new technique provides high-resolution images of the hair-like structures called cilia that line nasal airways as well as detailed features of the clearance of mucus, which is impaired in people with CF, causing significant morbidity.
The thump, thump of a baby's heartbeat is a milestone in any pregnancy. Now, researchers at Stevens Institute of Technology have developed a technique that could allow expectant parents to hear their baby's heartbeat continuously at home with a non-invasive and safe device that is potentially more accurate than any fetal heartrate monitor currently available in the market.
DES PLAINES, IL -- Opioid use at the three-month follow-up in emergency department patients discharged with an opioid prescription for acute pain is relatively low and not necessarily synonymous with opioid misuse. That is the conclusion of a study to be published in the August 2019 issue of Academic Emergency Medicine (AEM), a journal of the Society for Academic Emergency Medicine (SAEM).
University of Houston researcher Chandra Mohan is reporting in Arthritis Research and Therapy that clotting proteins, both those that promote blood clots (pro-thrombotic) and those that work to dissipate them (thrombolytic), are elevated in the urine of patients who suffer from lupus nephritis (LN).
In an analysis of information on 10,463 UK patients diagnosed with colorectal cancer from 2006 to 2013, patients under the age of 50 years were more likely to initially experience non-specific symptoms before being referred to cancer specialists.
Nonsteroidal anti-inflammatory drugs (NSAIDs) can help to control the pain and inflammation in individuals with osteoarthritis (OA), but a new Arthritis & Rheumatology study suggests that NSAIDs contribute to cardiovascular side effects in these patients.
An analysis of published studies found that Nordic walking--a low impact aerobic activity consisting in walking with poles--can benefit patients with breast cancer by having a positive impact on swelling, physical fitness, disability, and quality of life.
The European Journal of Cancer Care analysis, which included nine relevant studies, revealed no adverse effects associated with the exercise.