Body | Page 5230 | Science Codex

Epigenetics to shape stem cell future

Everyone hopes that one day stem cell-based regenerative medicine will help repair diseased tissue. Before then, it may be necessary to decipher the epigenetic signals that give stem cells their unique ability to self-renew and transform them into different cell types.

The hype over epigenetic research is because it opens up the possibility of reprograming cells. By manipulating epigenetic marks, cells can be transformed into other cell types without changing their DNA. It is simply a question of adding or removing the chemical tags involved.

Cancer is a stem cell issue, says European Science Foundation

There is an urgent reason to study stem cells: stem cells are at the heart of some, if not all, cancers. Mounting evidence implicates a clutch of rogue stem cells brandishing ‘epigenetic’ marks as the main culprits in cancer. Wiping out tumours for good, some biologists believe, depends on uprooting these wayward stem cells.

RNAi shows promise in gene therapy, Stanford researcher says

Three years ago Mark Kay, MD, PhD, published the first results showing that a biological phenomenon called RNA interference could be an effective gene therapy technique. Since then he has used RNAi gene therapy to effectively shut down the viruses that cause hepatitis and HIV in mice.

Cancer cells more likely to genetically mutate

When cells become cancerous, they also become 100 times more likely to genetically mutate than regular cells, researchers have found. The findings may explain why cells in a tumor have so many genetic mutations, but could also be bad news for cancer treatments that target a particular gene controlling cancer malignancy.

Mathematical model predicts cholera outbreaks

A mathematical model of disease cycles developed at the University of Michigan shows promise for predicting cholera outbreaks.

Speaking in a symposium titled "New Vistas in the Mathematics of Ecology and Evolution" at the annual meeting of the American Association for the Advancement of Science in San Francisco, theoretical ecologist Mercedes Pascual will discuss how models that she and coworkers have developed can aid short-term forecasting of infectious diseases, such as cholera, and inform decisions about vaccination and other disease-prevention strategies.

Scientific literacy happens -- when students think for themselves

Give college students less instruction and more freedom to think for themselves in laboratory classes, and the result may be a four-fold increase in their test scores.

So says Steve Rissing, a professor of evolution, ecology and organismal biology at Ohio State University. Rissing played a major role in revamping the way the university teaches its introductory-level biology courses.

The Search For A Chlamydia Vaccine

It's the most common bacteria-related sexually transmitted disease in the United States, so researchers at The University of Texas at San Antonio's South Texas Center for Emerging Infectious Diseases (STCEID) and The University of Texas at San Antonio Health Science Center have partnered to discover a vaccine that will prevent Chlamydia.

Antibody signal may redirect inflammation to fuel cancer

As evidence mounts that the body's normally protective inflammation response can drive some precancerous tissues to become fully malignant, UCSF scientists report discovering an apparent trigger to this potentially deadly process.

Typically, the "innate" immune system's Pac-Man-like white blood cells, or leukocytes, engulf and destroy invading microbes when receptors on their surface receive a signal from serum in the blood -- often an antibody produced by a B cell in the separately evolved "acquired" immune system.

Hunting martian fossils best bet for locating Mars life

Hunting for traces of life on Mars calls for two radically different strategies, says Arizona State University professor Jack Farmer. Of the two, he says, with today’s exploration technology we can most easily look for evidence for past life, preserved as fossil "biosignatures" in old rocks.

Farmer is a professor of geological sciences in ASU’s School of Earth and Space Exploration, where he heads the astrobiology program. He is reporting on his work today (Feb. 16) at the annual meeting of the American Association for the Advancement of Science in San Francisco.

Phospholipids in the cell membrane help regulate ion channels

Though the cell membrane is a protective barrier, it also plays a role in letting some foreign material in — via ion channels that dot the cell’s surface. Now new research from the Nobel Prize-winning laboratory that first solved the atomic structure of several such channels shows that their function is controlled in part by a complex interaction between a channel’s voltage sensor and the cell membrane immediately adjacent to it.

New bird, bat species revealed by extensive DNA barcode studies

At unprecedented levels of difficulty involving highly biodiverse and continent-sized landscapes, scientists have successfully tested their ability to identify and DNA "barcode" entire assemblages of species -- the prelude to a genetic portrait of all animal life on Earth.

Get Ready For A Bionic Eye

Patients who have gone blind are a step closer to perhaps one day regaining some of their sight.

Researchers at the USC Doheny Eye Institute announced today the next step in their efforts to advance technology that hopefully will help patients with retinitis pigmentosa and macular degeneration regain some vision using an implanted artificial retina.

Finding The Climate Key Genetically

A University of Queensland microbiologist is part of an international team that has identified a bacterial gene that may affect climate and weather. Dr Phil Bond, from UQ's Advanced Wastewater Management Centre, and his former colleagues at the University of East Anglia in England, have found how a particular type of marine bacteria – Marinomonas – generates a compound that is a key component in global sulfur and carbon cycles.

Antarctic temperatures disagree with climate model predictions

A new report on climate over the world's southernmost continent shows that temperatures during the late 20th century did not climb as had been predicted by many global climate models.

This comes soon after the latest report by the Intergovernmental Panel on Climate Change that strongly supports the conclusion that the Earth's climate as a whole is warming, largely due to human activity.

Quantum hall effect observed at room temperature

Using the highest magnetic fields in the world, an international team of researchers has observed the quantum Hall effect – a much studied phenomenon of the quantum world – at room temperature.