Body
A new mathematical modeling study by Ashish Goyal and colleagues, informed by data collected from 25 patients hospitalized with COVID-19 in 4 different countries, offers some important new insights into the optimal timing of 4 different antiviral therapies to combat the disease.
An experimental vaccine, designed to enlist the body's own immune system to target cancer cells, has shown promise for treating and preventing cancer in mice.
The vaccine was created to target a gene called KRAS that is involved in the development of many types of cancer, including lung, bowel and pancreatic cancer.
Researchers from the same team have also found a new way to spot and treat aggressive forms of lung cancers that are able to evade the body's immune system.
Scientists cannot be expected to drop everything they're working on to turn their attention to beating COVID-19, according to the winner of the 2019 Nobel Prize in Physiology or Medicine, Professor Sir Peter Ratcliffe.
FINDINGS
Untreated HIV infection is linked with epigenetic changes that suggest rapid aging. A new study by UCLA researchers shows that antiretroviral therapy given over two years was unable to completely restore age-appropriate epigenetic patterns, leaving patients more susceptible to aging-related illnesses.
BACKGROUND
This is the first longitudinal study conducted to investigate the contribution of HIV-infection, versus treatment, on the acceleration of aging epigenetics -- external factors that affect the function of genes -- in this population of adults.
Modelling analysis of measures in 131 countries confirms that combined measures are likely to reduce the R more than individual measures.
Authors looked at four possible combinations of measures, with the least comprehensive package of measures (ban on public events and gatherings of more than ten people) reducing R by 29% on day 28, increasing to a 52% reduction for the most comprehensive package similar to a lockdown.
The study estimated that there was a 1 to 3 week delay in the effect of imposing or lifting measures on the R number.
Highlights
Adults with glomerular diseases have a 2.5-times higher risk of developing cardiovascular disease than individuals in the general population.
Results from the study will be presented online during ASN Kidney Week 2020 Reimagined October 19-October 25.
Washington, DC (October 24, 2020) -- Adults with glomerular diseases--which affect the kidney's filtering units where blood is cleaned--face a high risk of developing heart problems, according to a study that will be presented online during ASN Kidney Week 2020 Reimagined October 19-October 25.
Washington, DC (October 22, 2020) -- A recent study has validated a new patient-reported outcome measure that assesses fatigue in patients receiving long-term dialysis treatments. The results appear in an upcoming issue of CJASN.
GRAND RAPIDS, Mich. (Oct. 22, 2020) -- Scientists have developed a simple, experimental blood test that distinguishes pancreatic cancers that respond to treatment from those that do not. This critical distinction could one day guide therapeutic decisions and spare patients with resistant cancers from undergoing unnecessary treatments with challenging side effects.
The findings were published today in Clinical Cancer Research, a journal of the American Association for Cancer Research.
With nearly half of the world's population at risk for life-threatening malaria infections, University of Maryland School of Medicine (UMSOM) researchers and their colleagues identified an important public health measure to control the disease. Use of preventive antimalarial treatments reduces by half the number of malaria infections among schoolchildren, according to a new analysis published today in The Lancet Global Health.
Sepsis is estimated to cause 11 million deaths every year in the world. Its treatment is based on the use of antibiotics and organ support measures, but many times it fails due to unsuccessful attempts at modulating the immune response. Sepsis is a complication that occurs from a generalized infection and is characterized by a dysregulated immune response that entails a high risk of death.
Numerous studies over the last few weeks have pointed out that the effects of the Corona pandemic on people's mental health can be enormous and affect large parts of the population. In spring, Prof. Tatjana Schnell from the Existential Psychology Lab at the Department of Psychology at the University of Innsbruck, Austria, together with her colleague Henning Krampe from the Departement of Anaesthesiology at Charité - Universitätsmedizin Berlin, Germany, launched a comprehensive quantitative study.
Traumatic brain injury is a major cause of disability and can have major consequences for patients and their loved ones. Patients can suffer a range of physical, cognitive, behavioural and emotional problems.
People who fall and hit their head, or who are in traffic accidents or suffer other head injuries, often undergo an MRI if doctors suspect a brain injury. But it can be difficult to predict from an MRI exactly what kinds of issues, if any, will arise from the trauma.
KNOXVILLE, Tenn. -- In the tropics and subtropics, families and communities frequently rely on bushmeat for food security as well as basic income. So, while the harvest and trade of wildlife are illegal in many locales, the practice is commonplace, and with it comes the potential for transmission of a zoonotic disease among human populations.
BOSTON -- Researchers have validated a new radiolabeled molecule that can be used with imaging tests to accurately detect and characterize brain injury. The team, led by investigators at Massachusetts General Hospital (MGH), recently received clearance from the U.S. Food and Drug Administration (FDA) to initiate a first-in-human study with the strategy.
DALLAS - Oct. 22, 2020 - Two new UT Southwestern studies published today report some surprising findings: Only half of practicing physicians are registered to vote, and the most common obstacle faced by resident physicians is the lack of time to vote. The researchers say finding ways to increase voter participation among doctors is critical as the nation tackles health care issues.