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The Equalizer: An engineered circuit for uniform gene expression

Eurekalert - Jul 12 2021 - 00:07
Researchers deloped a new genetic circuit called the Equalizer that leads to uniform gene expression.
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A redundant modular network supports proper brain communication

Eurekalert - Jul 12 2021 - 00:07
In a mouse model, brain regions involved in working memory present a modular network organization that is critical for persistent neural activity.
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The fine nose of storks

Eurekalert - Jul 12 2021 - 00:07
Smell leads storks to freshly mown meadows
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Novel screening approach improves diagnosis of metabolic disorders in newborns

Eurekalert - Jul 12 2021 - 00:07
A screening method known as untargeted metabolomics profiling can improve the diagnostic rate for inborn errors of metabolism, a group of rare genetic conditions, by about seven-fold when compared to the traditional metabolic screening approach.
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Role of host genetics on gut microbiome is near-universal, but environmentally-dependent

Eurekalert - Jul 12 2021 - 00:07
In new research from the University of Minnesota, University of Notre Dame and Duke University, scientists found that genetics nearly always plays a role in the composition of the gut microbiome of wild baboons.
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New study may offer treatment guidance for MIS-C

Eurekalert - Jul 12 2021 - 00:07
Children and adolescents with multisystem inflammatory syndrome in children (MIS-C) who are treated initially with intravenous immune globulin (IVIG) and glucocorticoids have reduced risk for serious short-term outcomes, including cardiovascular dysfunction, than those who receive an initial treatment of IVIG alone, a new study finds.
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Electric delivery vehicles: When, where, how they're charged has big impact on greenhouse gas emissi

Eurekalert - Jul 12 2021 - 00:07
The transportation sector is the largest contributor to greenhouse gas emissions in the United States, and a lot of attention has been devoted to electric passenger vehicles and their potential to help reduce those emissions.
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Genetic analysis to help predict sunflower oil properties

Eurekalert - Jul 12 2021 - 00:07
Skoltech researchers and their colleagues from the University of Southern California have performed a genetic analysis of a Russian sunflower collection and identified genetic markers that can help predict the oil's fatty acid composition.This work is the first large-scale study of the Russian genetic collection of sunflowers and one of the first attempts to introduce genomic selection into the process of obtaining new varieties in our country.
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MaxDIA -- taking proteomics to the next level

Eurekalert - Jul 12 2021 - 00:07
A new software improves data-independent acquisition proteomics by providing a computational workflow that permits highly sensitive and accurate data analysis
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Study shows mental health, support, not just substance misuse key in parental neglect

Eurekalert - Jul 12 2021 - 00:07
Substance abuse has long been viewed as the top factor in parents neglecting children. But a new study has found that presence of clinical depression and social supports, when compared with substance use, are also key in predicting neglect; should be part of social services, researcher argues.
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Fear of rejection vs. joy of inclusion: Faith communities from LGBTQ+ perspectives

Eurekalert - Jul 12 2021 - 00:07
New research from Megan Gandy in West Virginia University's School of Social Work suggests that faith communities can benefit LGBTQ+ individuals.
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Sensing "junk" RNA after chemotherapy enhances blood regeneration

Eurekalert - Jul 12 2021 - 00:07
Scientists from the MPI-IE reveal that during hematopoietic regeneration, RNA expressed from a part of the genome considered "junk DNA" is used by hematopoietic stem cells to get activated and proliferate. The study published in the scientific journal Nature Cell Biology shows that these so-called transposable elements make RNA after chemotherapy and activate an immune receptor which induces inflammatory signals enhancing hematopoietic stem cell cycling and thus participating in the regeneration of the hematopoietic system.
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A third of teens, young adults reported worsening mental health during pandemic

Eurekalert - Jul 12 2021 - 00:07
As typical social and academic interaction screeched to a halt last year, many young people began experiencing declines in mental health, a problem that appeared to be worse for those whose connections to family and friends weren't as tight, a new study has found.
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Training helps teachers anticipate how students with learning disabilities might solve problems

Eurekalert - Jul 12 2021 - 00:07
North Carolina State University researchers found that a four-week training course made a substantial difference in helping special education teachers anticipate different ways students with learning disabilities might solve math problems.
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Hijacked immune activator promotes growth and spread of colorectal cancer

Eurekalert - Jul 12 2021 - 00:07
Through a complex, self-reinforcing feedback mechanism, colorectal cancer cells make room for their own expansion by driving surrounding healthy intestinal cells to death - while simultaneously fueling their own growth. This feedback loop is driven by an activator of the innate immune system. Researchers from the German Cancer Research Center (DKFZ) and the University of Heidelberg discovered this mechanism in the intestinal tissue of fruit flies.
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People given 'friendly' bacteria in nose drops protected against meningitis

Eurekalert - Jul 12 2021 - 00:07
A world-first trial has shown that nose drops of modified 'friendly' bacteria protect against meningitis.
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Sea-level rise may worsen existing Bay Area inequities

Eurekalert - Jul 12 2021 - 00:07
Researchers examined the number of households unable to pay for damages from coastal flooding to reveal how sea-level rise could threaten the fabric of Bay Area communities over the next 40 years.
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Naturally abundant venom peptide from ants can activate a pseudo allergic pathway unravelling a novel immunomodulatory pathway of MRGPRX2

Eurekalert - Jul 12 2021 - 00:07
Ants are omnipresent, and we often get blisters after an ant bite. But do you know the molecular mechanism behind it? A joint research team have identified and demonstrated a novel small peptide isolated from the ant venom can initiate an immune pathway via a pseudo-allergic receptor MRGPRX2. The study has recently been published in a top journal in Allergy - The Journal of Allergy and Clinical Immunology.
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Progress towards new treatments for tuberculosis

Eurekalert - Jul 12 2021 - 00:07
Boosting the body's own disease-fighting immune pathway could provide answers in the desperate search for new treatments for tuberculosis. Tuberculosis still represents an enormous global disease burden and is one of the top 10 causes of death worldwide.The study uncovered how cells infected with tuberculosis bacteria can die, and that using new medicines to enhance particular forms of cell death decreased the severity of the disease in a preclinical model.
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Human environmental genome recovered in the absence of skeletal remains

Eurekalert - Jul 12 2021 - 00:07
Ancient sediments from caves have already proven to preserve DNA for thousands of years. The amount of recovered sequences from environmental sediments, however, is generally low, which difficults the analyses to be performed with these sequences. A study led by Ron Pinhasi and Pere Gelabert of the University of Vienna and published in Current Biology successfully retrieved three mammalian environmental genomes from a single soil sample of 25,000 years bp obtained from the cave of Satsurblia in the Caucasus (Georgia).
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