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Researchers at Huntsman Cancer Institute have found critical new insights into how cells defend against melanoma. In a report published in Nature Communications, the team describes how an enzyme called nicotinamide phosphoribosyltransferase, or NAMPT, initiates antitumor activity. The researchers suggest that new therapies strengthening this pathway in immune cells could be the foundation for more effective treatments against melanoma.

Annals of Family Medicine is a peer-reviewed, indexed research journal that provides a cross-disciplinary forum for new, evidence-based information affecting the primary care disciplines.

Extreme weather is harming UK agriculture - but many farmers have not yet made adapting to the effects of the climate emergency a priority, a new study shows.

A study from the University of Kansas interviewed students with disabilities about their experiences with pandemic education. They found the students relied on their own resilience, and advocated for themselves, displaying a strengths-based approach that could serve as a model for all students following the pandemic.

Researchers from Tel Aviv University developed a product that protects against inflammatory bone destruction; new patent pending. The product is intended to prevent bone loss around orthopedic and dental implants as well as natural teeth.

A Trinity College study demonstrates an extremely high burden of physical and mobility problems experienced by people who are homeless and were admitted for inpatient care to an acute hospital in Dublin and Overall the study provided visible evidence of accelerated physical ageing among this cohort relative to the general population.

Two groups of researchers at Sandia National Laboratories have published papers on the droplets of liquid sprayed by coughs or sneezes and how far they can travel under different conditions.Both teams used Sandia's decades of experience with advanced computer simulations studying how liquids and gases move for its nuclear stockpile stewardship mission.

New research from Washington University in St. Louis shows how animals and bacteria differ in the enzyme they use to attach heme to the cytochrome. The results help illuminate a promising target for new antibiotics.

They are some of the most beautiful, and elusive, animals on the plant. Leopards. In a major scientific step, the whole genome DNA sequence of 23 individual leopards have been interpreted.

DNA is composed of nucleobases represented by the letters A, T, G and C. They form the basis of the genetic code and are present in all living beings. But in a bacteriophage, another base, represented by the letter Z, exists. This exception, the only one observed to date, has long remained a mystery. Scientists from the Institut Pasteur and the CNRS, in collaboration with CEA, have now elucidated the biosynthesis pathway of this base.

It is projected that up to 152 million people worldwide will be living with Alzheimer's disease (AD) by 2050. To date there are no drugs that have a substantial positive impact on either the prevention or reversal of cognitive decline. A growing body of evidence finds that targeting lifestyle and vascular risk factors have a beneficial effect on overall cognitive performance. A new review in the Journal of Alzheimer's Disease, published by IOS Press, examines research that finds spiritual fitness, a new concept in medicine that centers on psychological and spiritual wellbeing, and Kirtan Kriya, a simple 12-minute meditative practice, may reduce multiple risk factors for AD.

A group of scientists say now is the time to talk about reintroducing jaguars (Panthera onca) into the U.S. In a study published today in the journal Conservation Science and Practice, the authors provide a prospective framework for this effort and describe "righting a wrong" done to "America's Great Cat" in the Southwest more than 50 years ago.

Marie-Claude Bourgeois-Daigneault and her team at the CRCHUM are using mice to show how a combination of peptides and oncolytic viruses, used as an adjuvant, can provide effective immunization against cancer.

A new approach to road safety that relies on design and engineering principles--the "Safe System" approach--could lead to dramatic reductions in vehicle-related deaths and injuries if implemented in the US.

In a new article published in the journal Immunity, Moffitt Cancer Center researchers show that TIM-3 inhibits the STING signaling pathway in dendritic cells, thereby blocking their ability to elicit an immune response.

Like other medical specialties at the start of the COVID-19 pandemic, orthopaedic surgery rapidly pivoted from in-person visits to remote appointments via telemedicine. Analysis of that initial experience finds that some groups of patients faced persistent or worsening disparities as the shift to telemedicine occurred, reports Clinical Orthopaedics and Related Research® (CORR®), a publication of The Association of Bone and Joint Surgeons®. The journal is published in the Lippincott portfolio by Wolters Kluwer.

Argonne scientists across several disciplines have combined forces to create a new process for testing and predicting the effects of high temperatures on refractory oxides.

A new study from the University of Chicago has found that the photosynthetic bacterium Synechococcus elongatus uses a circadian clock to precisely time DNA replication, and that interrupting this circadian rhythm prevents replication from completing and leaves chromosomes unfinished overnight.

Low doses of a four-drug combination helps prevent the spread of cancer in mice without triggering drug resistance or recurrence, shows a study published today in eLife.

An investigational gene therapy can safely restore the immune systems of infants and children who have a rare, life-threatening inherited immunodeficiency disorder, according to research supported in part by the National Institutes of Health. The researchers found that 48 of 50 children who received the gene therapy retained their replenished immune system function two to three years later and did not require additional treatments for their condition, known as ADA-SCID.