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Just as the skeleton and muscles move the human body and hold its shape, the cells of the body are stabilised and moved by a cellular skeleton. This cellular skeleton is a dynamic structure, constantly changing and renewing. It consists of different types of protein filaments, which include intermediate filaments and microtubules. Researchers from Göttingen University are the first to succeed in observing a direct interaction between microtubules and intermediate filaments outside the cell, and in measuring this.

In a study of patients waiting for a kidney transplant, those who experienced various symptoms had a higher risk of dying while on the waitlist.Symptoms tended to increase or remain unchanged between transplant evaluation and transplantation; however, at three months after transplantation, nine of 11 symptoms lessened.

Primary nephrotic syndrome is characterized by high urinary excretion of protein, low protein in the blood, high cholesterol, and swelling in the arms and legs. A new analysis highlights the high risk of kidney failure and different cardiovascular complications in patients with primary nephrotic syndrome.

New research reveals how key proteins interact to regulate the body's response to stress.

A comprehensive health-screening program in rural northern KwaZulu-Natal, South Africa, has found a high burden of undiagnosed or poorly controlled non-communicable diseases, according to a study published in The Lancet Global Health.

A research group of scientists from North America, Europe and Africa concluded that animals' ability to respond to climate change likely depends on how well they modify their habitats, such as nests and burrows.

Scientists have long known the brain's hippocampus is crucial for long-term memory. Now a new Northwestern Medicine study has found the hippocampus also plays a role in short-term memory and helps guide decision-making. The findings shed light on how the hippocampus contributes to memory and exploration, potentially leading to therapies that restore hippocampal function, which is impacted in memory-related aging and neurodegenerative diseases such as dementia, the study authors said.

This study explores for the first time how the mutation-independent effect of environmental carcinogens leads to the recruitment of CD8+ T cells, the dominant antitumor cell type. Research raises the possibility of an injection of a chemokine known as CCL21 into a tumor to induce an antitumor response through CD8+ T cells.

Mathematicians created a novel mathematical model and found that a mixture of repayment strategies might be best--depending on how much is borrowed and how much income the borrower has.

At least so far, the currently limited research base does not establish that cannabis has additional adverse effects on brain development or functioning in adolescents or young adults with attention-deficit/hyperactivity disorder (ADHD), concludes a review in the July/August issue of Harvard Review of Psychiatry. The journal is published in the Lippincott portfolio by Wolters Kluwer.

In the visual thalamus, neurons are in contact with both eyes but respond to only one

An experimental artificial heart includes an autoregulation control mechanism, or Auto-Mode, that can adjust to the changing needs of patients treated for end-stage heart failure. Outcomes in the first series of patients managed with the new heart replacement pump in Auto-Mode are presented in the ASAIO Journal, official journal of the American Society for Artificial Internal Organs. The journal is published in the Lippincott portfolio by Wolters Kluwer.

A new study paves the way for the development of next generation therapeutics for the prevention and treatment of Clostridioides difficile infection (CDI), the most frequent cause of healthcare-acquired gastrointestinal infections and death in developed countries.

A new study provides insight into what may contribute to men's suicide vulnerability.

Lake Victoria, which came under the spotlight in 2004 by the documentary "Darwin's nightmare", is not only suffering from the introduction and commercialisation of the Nile perch. A study lead researchers from the University of Liège (Belgium) has highlighted other worrying phenomena, particularly climatic ones, which have an equally important impact on the quality of the lake's waters.

Will a reduction in tau protein in brain neurons protect against Parkinson's disease and Lewy body dementias? A new study suggests the answer is no. If this is borne out, that result differs from Alzheimer's disease, where reducing endogenous tau levels in brain neurons is protective for multiple models of the disease -- and thus suggests that the role of tau in the pathogenesis of Lewy body dementias is distinct from Alzheimer's disease.

In a new study, a team of researchers uncovered new mechanisms underlying an important type of resistance to modern prostate cancer drugs called lineage plasticity, where castration-resistant prostate cancers undergo a deadly identity switch. They also outline a promising path to overcoming this form of resistance: BET bromodomain inhibitors.

An international team led by Princeton researchers explored quantum structures called kagome lattices and found insights into the fundamental understanding of quantum order leading to orbital magnetism - that is, magnetism that arises from extended orbital motion of electrons rather than their spin. The findings hint at behaviors that could be precursors of unconventional superconductivity and an anomalous Hall effect.

A science-based intervention relieved hiccups for 92% of 249 users who self-reported the effectiveness of the tool. The study is in JAMA Network Open and is from The University of Texas Health Science Center at San Antonio (UT Health San Antonio) and collaborating investigators.

It could be a milestone on the path to detecting life on other planets: Scientists under the leadership of the University of Bern and of the National Centre of Competence in Research (NCCR) PlanetS detect a key molecular property of all living organisms from a helicopter flying several kilometers above ground. The measurement technology could also open up opportunities for remote sensing of the Earth.