Science 2.0

No one likes getting a needle but most want a vaccine. A new paper shows progress for messenger RNA (mRNA), that can be sprayed and inhaled thanks to improved lipid-polymer nanoparticle technology for holding mRNA that is stable when nebulized and successfully delivers aerosols, liquid droplets, in mouse lungs. 

A mouse study means this is only EXPLORATORY but the authors of the paper, including scientists from oRNA Therapeutics (RNA medicine) and Moderna (mRNA medicine), have filed for a patent while they get ready to see about human trials. 

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Attorney Robert F. Kennedy Jr. and his US followers over the last 25 years have staunchly opposed vaccines, latching on to any claim that they cause autism or should be available for lawsuits even if they harm no one.

They really won't like a new experimental vaccine for Smallpox and Monkeypox that avoids the side effects of a current live virus version while not needing two doses, as the replication-deficient virus version does. It uses the horsepox virus as a protective agent to confer the safety of a multi-dose vaccine in a single shot. 

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Attorney Robert F. Kennedy Jr. and his US followers over the last 25 years have staunchly opposed vaccines, latching on to any claim that they cause autism or should be available for lawsuits even if they harm no one.

They really won't like a new experimental vaccine for Smallpox and Monkeypox that avoids the side effects of a current live virus version while not needing two doses, as the replication-deficient virus version does. It uses the horsepox virus as a protective agent to confer the safety of a multi-dose vaccine in a single shot. 

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General medicine, routine visits and such, have gradually gone from M.D.s to including Osteopaths and now Physicians Assistants with no decline in quality, and Large Language Models, colloquially called "Artificial Intelligence", like ChatGPT can assist at very low cost.

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General medicine, routine visits and such, have gradually gone from M.D.s to including Osteopaths and now Physicians Assistants with no decline in quality, and Large Language Models, colloquially called "Artificial Intelligence", like ChatGPT can assist at very low cost.

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Italy as we know it today had not been such since the days of the Roman Empire. You can see that last remnant today in the existence of The Vatican smack in the middle of Rome but at one point they held a substantial amount of territory. 

Like Americans, Italians are inherently rebellious. If you are on a plane flight and a flight attendant complains about someone smoking a cigarette, savvy travelers know it's an Italian in the bathroom. It is part of the reason Americans love Italian people. Unlike Americans, Italians had to fight not only each other for over a thousand years, they had to fend off French and Germans and even Africans.

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Italy as we know it today had not been such since the days of the Roman Empire. You can see that last remnant today in the existence of The Vatican smack in the middle of Rome but at one point they held a substantial amount of territory. 

Like Americans, Italians are inherently rebellious. If you are on a plane flight and a flight attendant complains about someone smoking a cigarette, savvy travelers know it's an Italian in the bathroom. It is part of the reason Americans love Italian people. Unlike Americans, Italians had to fight not only each other for over a thousand years, they had to fend off French and Germans and even Africans.

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Our outrage over Russia’s invasion of Ukraine is due to our preference for democracy over autocracy, and to the danger of Russia pushing further westward into Europe. Perhaps most of all, we abhor the idea of one country violating the borders of another one.

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Our outrage over Russia’s invasion of Ukraine is due to our preference for democracy over autocracy, and to the danger of Russia pushing further westward into Europe. Perhaps most of all, we abhor the idea of one country violating the borders of another one.

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In 2008, fresh off a decisive victory over Democratic establishment candidate Senator Hillary Clinton in the primary and one over highly-regarded Senator John McCain in the general election, President-elect Obama began to engage in worrisome behavior.

His transition team, those who set the tone for his Cabinet and first 100 days, was over-represented with UFO believers. His inner circle included a guy who thoughts girls can't do math. I was only two years into science media by then so I believed that science academics were a cross-section of America - diverse - and that President George W. Bush hated science and everything else. Yet none of the choices President-elect Obama made seemed to concern those who insisted that science was paramount.(1)  

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Nowadays we study the Universe using a number of probes and techniques. Over the course of the past 100 years we moved from barely using optical telescopes, that give us access to the flux of visible photons from galaxies, supernovae, and other objects of interest, to exploiting photons of any energy - gamma rays, x rays, ultraviolet and infrared radiation, microwaves; and then also using charged cosmic radiation (including protons and light nuclei, electrons and positrons), neutrinos, and lastly, gravitational waves. 

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Cigarettes are the top lifestyle risk factor for getting cancer, though alcohol and obesity have begun to close the gap as awareness of the risks of cigarettes, coupled with more nicotine smoking cessation and harm reduction tools, have caused cigarette use to decline.

Even if you get cancer, quitting smoking improves outcomes. 

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When Senator Elizabeth Warren had her claims of native ancestry debunked by DNA testing, it was a warning shot to everyone who identifies that way - don't take a test. Most native Americans had long said that anyway, they knew how biology worked better Washington DC staffers. After five generations there is a chance there will be no evidence of an ancestor so natives have long told their communities not to participate. If there are only a few hundred in a database, the database is meaningless and natives tribes can continue their 'we agree you are and you agree you are native' policy rather than having evidence.

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Testicular cancer is the most common solid tumor in young men, with approximately 10,000 diagnoses in the U.S. each year.

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The 2024 Nobel Prize for Physics was awarded to John Hopfield and Geoffrey Hinton, who many have called “the godfather of AI”. The award seems apt for the time we are in.

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If cultural pundits can invent an Anthropocene Epoch then a Digital Epoch makes even more sense. In 2000, only in Japan did you see people on trains four inches from other humans chatting other humans on other trains, most of whom they'd never meet. Now that is everyone in the developed world.

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The American Society for the Prevention of Cruelty to Animals (ASPCA) vegetarian advocacy group has a paper out arguing that common broiler chickens not only learn more than the obvious, like which bowl has food, they get happier learning. 

Their marketing of the paper suggests they know who their key demographic is; middle-aged wealthy white women. And if you want them, you invoke "The Gilmore Girls", a show about a genius single mother with an equally intelligent daughter and they are best friends and talk really fast and use a lot of Proust references.

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Earlier this year I mentioned here that I would be writing an article on how the utility function of experiments in fundamental science could be specified, as an enabling step toward the formalization of a co-design optimization problem. Now, as the deadline for submission approaches and the clock keeps ticking, I am returning to this topic and am mulling over the matter, so I thought it would be appropriate to dump here a few thoughts on the matter.

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Dr. Johanna Olson-Kennedy is a prominent physician and long-time evangelist for chemical interventions among trans youth and has been conducting those chemical interventions for nearly two decades.

It remains controversial, critics say young people can't provide informed consent for many, many things but Dr. Olson-Kennedy wanted to do a U.S. study similar to one done in Netherlands which found kids given these interventions were happier.(1)

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Last year, the American Psychological Association (APA) issued a health advisory on the use of social media by adolescents. This was based on mounting scientific evidence that social media has both benefits and risks for teens, and that parents and guardians needed better advice on how to balance the two.

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