The report about sphincter of oddi hypomotility and sphincter of oddi dilation was relatively rare. Whether sphincter of oddi hypomotility and duodenal-biliary reflux existed in these patients and if these patients had abnormal secretion of gastrointestinal hormones need further research.
A research article to be published on 7 July 2008, in the World Journal of Gastroenterology addresses this question. 45 patients with a T tube after cholecystectomy and choledochotomy were divided into reflux group and control group by measuring the amounts of radioactivity of Tc99m-labeled diethylene triamine pentaacetic acid (DTPA) in the bile. The level of plasma motilin and serum gastin of the patients and 12 healthy volunteers were measured by radioimmunoassay. Among them, 34 were selected randomly undergone choledochoscope manometry. Sphincter of Oddi basal pressure (SOBP), amplitude (SOCA), frequency of contractions (SOF), duration of contractions (SOD), duodenal pressure (DP), commen bile duct pressure (CBDP) were scored and analyzed.
They found that many patients with a T tube after cholecystectomy and choledochotomy do have duodenal-biliary reflux. Most of them do have sphincter of Oddi hypomotility and the level of plasma motilin and serum gastrin of them decreased. The level of plasma motilin showed obviously positive correlation with sphincter of Oddi basal pressure and the level of serum gastrin showed apparent positive correlation with sphincter of Oddi basal pressure and common bile duct pressure. The disorder of gastrointestinal hormone secretion may result in sphincter of Oddi dysfunction and the sphincter of Oddi hypomotility caused by it had intimate relationship with duodenal-biliary reflux and recurrence of gallstones.