Imaging probes that specifically target tumors can provide more sensitive and relevant information about the tumor compared to conventional, non-specific probes. Additionally, targeted probes can improve tumor detection, characterization, therapy stratification, and enhance selective delivery of anti-cancer drugs. A major limitation to the clinical use of such agents is their large size, which restricts their delivery to the tumor. Further, many tumors are characterized by altered permeability of tumor-associated blood vessels and increased fluid pressure within the tumors themselves, both of which prevent uptake of imaging agents. In this issue of JCI Insight, Heike Daldrup-Link of Stanford University and colleagues demonstrate that pre-treatment with an activin-like kinase 5 (Alk5) inhibitor enhances tumor-specific delivery of the contrast agent ferumoxytol. Their findings indicate that Alk5 inhibitors could be used to improve tumor imaging to facilitate diagnosis and treatment of solid tumors.
Source: Journal of Clinical Investigation