Toxicity and Challenges in Transferability of Surface-functionalized Metallic Nanoparticles
https://doi.org/10.15212/bioi-2020-0047
Announcing a new article publication for BIO Integration journal. In this review the authors Muhammad Arif Asghar, Rabia Ismail Yousuf, Muhammad Harris Shoaib, Muhammad Arif Asghar and Nazish Mumtaz from Jinnah Sindh Medical University, Karachi, Pakistan, University of Karachi, Karachi, Pakistan, Food and Marine Resources Research Centre, Pakistan and Benazir Bhutto Shaheed University, Karachi, Pakistan discuss toxicity and challenges in transferability of surface-functionalized metallic nanoparticles from animal models to humans.
The unique size and surface morphology of nanoparticles (NPs) have substantially influenced all aspects of human life, making nanotechnology a novel and promising field for various applications in biomedical sciences.
Metallic NPs have garnered immense interest over the last few decades due to their promising optical, electrical, and biological properties. However, the aggregation and the toxic nature of these NPs have restricted their utilization in more optimized applications. The optimum selection of biopolymers and biological macromolecules for surface functionalization of metallic NPs will significantly improve their biological applicability and biocompatibility.
The authors review recent strategies involved in surface functionalization of metallic NPs, their specific biomedical applications, and comparison of their in vitro, ex vivo, and in vivo toxicities with non-functionalized metallic NPs and discuss the various challenges for metallic NPs to undergo human clinical trials