Culture

Pottery related to unknown culture was found in Ecuador

image: This is a shard of an ancient ceramic vessel from the insufficiently studied San Pedro complex found on Real Alto site, Ecuador.

Image: 
FEFU press office

Archaeologists of Far Eastern Federal University (FEFU), Institute of Archeology and Ethnography SB RAS (Russia), Escuela Superior Politécnica del Litoral (ESPOL) (Ecuador), and Tohoku University (Japan) found shards of ceramic vessels referred to the cultural sediments of early periods of Real Alto site. Findings date back to 4640 - 4460 BC, this period borders with Valdivia, one of the oldest pottery-featured cultures in North and South America. A related article is published in Antiquity.

During the excavations at Real Alto site (Ecuador), Russian scientists found fragments of ceramic vessels at a depth of 75 cm to 1 meter. They belong to the insufficiently studied San Pedro complex. Radiocarbon analysis by mass spectrometer showed the pottery dates back to 4640-4460 BC. This period borders or coincides with the first stages of Valdivia culture, the worldwide famous ceramic figures, a kind of symbol of Ecuador, relates to. At the same time, fragments of San Pedro pottery differ from the Valdivian by decorative composition and way of its application.

The shards of San Pedro pottery correlate with fragments from Real Alto and other places of archaeological excavations retrieved in the 70s and 80s but attributed to no particular culture. Thus, the researchers received additional arguments to speak about new archaeological culture related to formative period. The one existed and developed simultaneously with Valdivia on the Pacific coast of Ecuador.

'The mass emergence of pottery was a kind of technical breakthrough associated with many aspects of human life and the level of economic development in different parts of the globe. Ceramic vessels belonging to different cultures developed simultaneously confirm that our ancestors had evolved in terms of cultural diversity. It is curious that, despite the different vectors of human development, in the technological sense we were moving in the same direction.' Alexander Popov said, Head of the Russian archeological expedition to Ecuador, Director of the Educational and Scientific Museum FEFU of the School of Arts and Humanities of Far Eastern Federal University.

According to the scientist, at the next stage of excavation, the research team will look for additional artifacts of new culture. Such findings may well help to determine conditions for the culture development with more preciseness.

Researchers believe that pottery fragments related to even more archaic time can be found in Ecuador, i.e., the more archaic cultural layer may exist. From that point, one will likely to find out whether pottery was invented in South America at the same time as in the other cultures of the globe or may it probably have been imported. The information will help to comprehend the processes of parallel development of people on the different sides of the Pacific Ocean and, in general, the multi-vector development of human communities.

FEFU researchers seek for common details and local options concerning the development of human civilization on opposite sides of the Pacific Ocean -- in South America and East Asia. Scientists compare the adaptation of the ancient man to environmental changes that influenced the economic, domestic and other aspects of the population.

Previously FEFU archaeologists in Ecuador have found ancient human remains dating back to 6 to 10 thousand years old. The excavations were carried out in Atahualpa canton, the findings belong to the Las Vegas archeological culture of the Stone Age.

Credit: 
Far Eastern Federal University

Quenching scientific curiosity with single-molecule imaging

video: Quenching scientific curiosity with single-molecule imaging.

Image: 
KAUST 2019

A single-molecule imaging technique, called protein-induced fluorescence enhancement (PIFE), has gained traction in recent years as a popular tool for observing DNA-protein interactions with nanometer precision. Yet, according to a new KAUST study, research laboratories have not been using the technique to its fullest potential.

The PIFE assay is predicated on the idea that DNA tagged with a fluorescent dye will glow brighter when proteins are bound in the vicinity. In many instances, this is true--which has led many scientists to adopt PIFE over other more labor-intensive techniques that rely on dual labeling of proteins and DNA.

But Samir Hamdan's graduate students Fahad Rashid, Manal Zaher and Vlad-Stefan Raducanu realized that protein binding to DNA-dye complexes could sometimes have the opposite effect as well. Instead of enhancing the fluorescent signal, protein interactions can sometimes dampen the glow, depending on certain properties of the system.

Hamdan credits the curiosity of his students for making this observation and detailing how it works. Inspiration from Rashid's previous work led the team to the phenomenon they call protein-induced fluorescence quenching (PIFQ). And as Rashid explains, "We set out to better define the conditions that lead to fluorescent booms or busts."

Through a combination of experimental and computational analyses, the KAUST team showed that the initial fluorescence state of the DNA-dye complex determines whether PIFE or PIFQ will result after protein binding. Without this knowledge, the likelihood of either event becomes equivalent to a coin toss, which can jeopardize the mechanistic interpretation of laboratory results.

"When insight into this initial state is gleaned from fluorescence and structural work, the anticipation of either effect becomes experimentally feasible," Raducanu explains.

Factors such as DNA sequence and dye position could tip the balance toward PIFE or PIFQ; the KAUST team got so good at interpreting the molecular code that they could accurately predict which would happen simply by measuring how these parameters influence the initial fluorescence state of the DNA-dye system.

"We turned every measurement into a game," Zaher says, "and we are happy to say that our hypothesis predicted the outcome more than 90 percent of the time!"

These novel insights should dramatically expand the reach and experimental promise of this powerful single-molecule imaging tool, predicts Raducanu. "By introducing PIFQ, we offer researchers in the field the possibility to address several biological questions where PIFE might not have been witnessed," he says.

Scientists may also opt to combine PIFE and PIFQ to decipher multistep and multiprotein processes with just a single DNA-dye construct.

"Taking into consideration the context-dependent nature of fluorescence modulation in the DNA-dye system opens the door to many possibilities in experimental design that could be tailored to researchers' needs," Zaher says.

"We now anticipate that interpretation of data and attribution of molecular events from single-molecule data will become easier and more precise," Rashid adds.

Credit: 
King Abdullah University of Science & Technology (KAUST)

Toward a CERN next generation circular collider

Back in January, CERN released a conceptual report outlining preliminary designs for a Future Circular Collider (FCC), which if built, would have the potential to be the most powerful particle collider the world over. Earlier this month attendees of the 2019 FCC week in Brussels got the first look at what this could look like with the release of the four volume FCC study conceptual design report (CDR).

In a special ceremony, on the first day of the cnference, Christian Caron (Executive Editor for the European Physical Journal (EPJ) at Springer Nature) handed over the four volumes to Fabiola Gianotti (CERN's Director General), Frédérick Bordry (CERN's Director of Accelerators & Technologies) and Michael Benedikt (FCC study leader).

Commenting on the publication of this report Michael Benedikt, FCC study leader remarked:

"The FCC design report is the outcome of the common effort of more than 1350 contributors from 34 countries including academic and industrial partners. I would like to thank each and every participant for helping to develop a global vision and preparing the construction of this unique future accelerator facility, which will serve the worldwide high-energy physics community throughout the 21st century. Together, we will continue reviewing the experimental challenges and exploiting opportunities for technological breakthroughs towards the realization of these machines."

Speaking after the ceremony, Christian Caron further commented:

''The development of a new research facility for particle physics that could push the energy and precision/intensity frontiers and unearth some of the mysteries of nature is incredibly exciting. As one of the leading research publishers, the team here at Springer Nature are incredibly proud to have partnered with CERN on the publication and publicizing of landmark projects and achievements at the frontier of high-energy physics and instrumentation. We are looking forward to a close collaboration in the forthcoming years where preparatory work picks up further pace."

The four volumes of the FCC CDR demonstrate the technical feasibility and identify the physics opportunities offered by the different collider options that lie at the core of the FCC study. Moreover, they point to key areas for future technological R&D (research and development) that would guarantee the efficient realization and operation of such a new research infrastructure for fundamental physics. The combination of a high luminosity lepton collider (FCC-ee) as a first step, followed by an energy-frontier proton collider (FCC-hh) will offer unprecedented precision in studying nature at its most fundamental scales through a diverse physics programme spanning 70 years.

Last but not least, the design report also addresses the significant socio-economic impact through investment in such large-scale scientific tools; and how their international and innovative nature can prove vital motors for economic and societal development on a broader scale.

The FCC design report informs the ongoing update of the European Strategy for Particle Physics and helps shape a global vision for high-energy physics research beyond the LHC. Today, the FCC is a worldwide collaboration of more than 150 universities, research institutes and industrial partners actively dedicated to the future of high-performant particle colliders and pursuing R&D on innovative technologies that could boost the efficiency of future particle accelerators. The broad range of scientific and technological disciplines as well as the related cultural diversity that some 1350 contributors introduced into the FCC design report considerably strengthens the collaborative spirit and integrative approach of this project, allowing in particular for unique perspectives that accelerated the progress of the study.

The first volume covering the "Physics Opportunities" was published in EPJC while the three volumes on "The Lepton Machine - FCC-ee", "The Hadron Machine - FCC-hh" and the "High-Energy LHC - HELHC" were published in EPJ Special Topics.

Springer Nature is a leading research, educational and professional publisher, providing quality content to our communities through a range of innovative platforms, products and services. Every day, around the globe, our imprints, books, journals and resources reach millions of people - helping researchers, students, teachers and professionals to discover, learn and achieve more. Through our family of brands, we aim to serve and support the research, education and professional communities by putting them at the heart of all we do, delivering the highest possible standards in content and technology, and helping shape the future of publishing for their benefit and for society overall. Visit: springernature.com/group and follow @SpringerNature.

CERN is the European Organization for Nuclear Research, known as CERN. Established in 1954, it is one of the world's largest and most respected centers for scientific research. The organization is based in a northwest suburb of Geneva on the Franco-Swiss border and has 23 member states. https://home.cern/

Credit: 
Springer

Decoding the causes of motor neuron disease: A new study shows the impact of genetics

Trinity College Dublin researchers have found that one in 347 men and one in 436 women can be expected to develop motor neuron disease during their lifetime. Motor neuron disease (MND) is a devastating condition which causes progressive paralysis, increasing physical disability and ultimately death within an average of two to three years. There are over 350 people in Ireland with MND, and one person is diagnosed every 3 days with the condition.

In a paper published today, Monday 22nd July 2019 in the prestigious American medical journal JAMA Neurology, the Irish team of researchers, led by Professor Orla Hardiman in the Academic Unit of Neurology and Dr Russell McLaughlin, Smurfit Institute of Genetics, Trinity College Dublin have conducted the largest ever study involving 1117 people diagnosed with motor neuron disease to address the question of "nature versus nurture" in the causes of MND.

The lead author, Dr Marie Ryan has shown that genetics account for about 52% of the risk of developing MND. This means that other important factors or exposures must also be present for the condition to develop, and that the overall risk of developing the disease among other family members remain low.

Dr Ryan also looked at those who carried known genetic mutations associated with motor neuron disease. In Ireland, in approximately 10% of people with motor neuron disease, the disease is caused by the abnormality in one gene called C9orf72, which runs in families. Dr Ryan found that those who carried an abnormal copy of this gene and developed MND were more likely to have inherited it from their mothers.

Dr Marie Ryan said: "While difference inheritance patterns based on who transmits the gene have been reported in other neurological disorders, this is the first time this kind of inheritance pattern has been discovered among those with motor neuron disease."

"The main message is that genetic and non-genetic factors contribute equally to one's risk of developing MND. The fact that 50% of the risk is found within our genes supports our ongoing search to identify the many interacting genes that contribute to the causes of motor neuron disease" she continued.

Professor Orla Hardiman, senior author said: "This will help us to find new treatments for this devastating condition, by pursing a precision medicine approach."

"We have already found that MND can cluster with other conditions including dementia, schizophrenia, bipolar disorder, autism and addiction disorders in around 30% of families. This means that multiple genetic factors working together are likely to play an important role in developing MND. Finding how these genes interact will help us to find new and better treatments" she concluded.

Credit: 
Trinity College Dublin

Surprising insight into Legionnaires' disease

image: Cryo-Electron microscopy structure of SidJ (yellow)-calmodulin (cyan) complex with the experimental cryo-EM map shown in grey.

Image: 
EMBL Grenoble

In order to control cellular processes and thwart the immune system, the bacterium Legionella pneumophilia, the cause of the notorious Legionnaires' disease, releases hundreds of enzymes. Biochemists at Goethe University have now elucidated important details in the interaction of bacterial effectors. They discovered how the regulatory enzyme SidJ keeps other dangerous virulence factors in check.

The incidence of Legionnaires' disease has increased in the past two decades. The natural habitat of Legionella is freshwater biotopes, where they mainly reproduce in amoebae. In addition, Legionella can also colonize water tanks or pipes and spread, for example, via poorly maintained air-conditioning systems. Contaminated aerosols are released into the air and trigger the infection. The pathogens cause, among others, pneumonia, which is often fatal in elderly patients or individuals with a weak immune system.

What makes Legionella so dangerous is its ability to multiply in phagocytes of the immune system by secreting virulence factors. Some of these effectors - the enzymes of what is known as the SidE family - are so toxic that without tight control they would instantly kill their host cells. However, since Legionella needs the host cells in order to multiply, it has developed a sophisticated mechanism for the precise metering of SidE enzyme activity. Details of this process are now reported by scientists at Goethe University and from Grenoble in the journal Nature.

They have shown that the regulator SidJ also released by Legionella works as an antidote to SidE enzymes, thus ensuring accurate control of SidE activity. The SidJ regulator is a glutamylase, i.e. it has a rare enzyme activity that allows amino acid glutamates to be linked together to form chains. In this case, SidJ attacks the central glutamate of SidE enzymes and inhibits their activity. So far, little is known about glutamylases - so the scientists were all the more surprised when they discovered that it is precisely this type of enzyme which is important for the coordinated interaction of the virulence factors of Legionella.

"This is a typical example of how completely unpredictable results drive research. Such discoveries are what make science such a fascinating and exciting profession," says Professor Ivan Dikic from the Institute of Biochemistry II and the Buchmann Institute for Molecular Life Sciences at Goethe University. "We can only gain a molecular understanding of the complex world of bacterial infections by working in interdisciplinary teams and combining methods from modern biochemistry and proteomics with cell and structural biology techniques."

The researchers also revealed how SidJ is activated in host cells: It requires the calcium-binding protein calmodulin found in mammalian cells. Cryo-electron microscopy played an important role in explaining the structure of the calmodulin-SidJ complex. "Glutamylation as a protein modification is understudied. Our finding that Legionella pneumophilia uses exactly this mechanism to sustain the infection certainly argues for more research in this field. For example, the extent to which Legionella utilizes this modification to regulate other cellular processes is completely unclear," explains Dr. Sagar Bhogaraju, who led the microscopic examinations at the European Molecular Biology Laboratory (EMBL) in Grenoble.

This so far unknown mechanism opens up new possibilities for research to inhibit the spread of Legionella in the host organism. "We're currently working on eliminating SidJ selectively by developing inhibitors for the glutamylase domain. In addition to the use of antibiotics, they could prevent the spread of Legionella pneumophilia in phagocytes," explains Dikic.

Credit: 
Goethe University Frankfurt

Former NFL players may face higher risk of atrial fibrillation

DALLAS, July 24, 2019 -- Former National Football League players were nearly 6 times more likely to have atrial fibrillation (AFib) compared to men of similar age who did not play professional football, according to new research in Journal of the American Heart Association, the Open Access Journal of the American Heart Association/American Stroke Association.

Atrial fibrillation, a type of irregular heartbeat that increases stroke risk, occurs when the electrical impulses that initiate each heartbeat fire erratically, causing the atria - the top chambers of the heart - to quiver. This can result in blood pooling and clotting in the atria. The clots can travel to a blood vessel leading to the brain and cause a stroke.

Previous studies have linked long-term participation in endurance sports, such as marathon running, with an increased risk of atrial fibrillation. This is the first study that associated an elite sport that requires muscle strength to a greater likelihood of having atrial fibrillation, according to the study authors.

"Although the study was observational, which means it identifies a relationship but does not prove cause and effect, the prolonged strength training involved in American football may increase heart chamber size and wall thickness, which can alter heart rhythms and electrical signals in the heart," said lead study author Dermot Phelan, MD, PhD, director of the Sports Cardiology Center at the Cleveland Clinic in Cleveland, Ohio.

Researchers compared 460 former National Football League players to 925 men from the Dallas Heart Study. Both groups were middle-aged and about half in each group were African American. They found:

5 % of former NFL players had AFib compared to 0.5 % of men in the control group.

Other predictors for developing AFib were older age, white race and higher weight, all of which have been recognized previously as risk factors for AFib.

The players group had overall lower risk factors for cardiovascular disease mortality, type 2 diabetes and high blood pressure, and had lower resting heart rates compared to the control group, yet the incidence of atrial fibrillation was still higher.

Former NFL athletes were 8 times more likely to have pacemakers compared to the control group. Pacemakers are devices that are implanted in a person's chest, usually to treat slow heart rates and other problems of electrical conduction in the heart.

"Most former NFL athletes with AFib were unaware of any symptoms and yet should have been taking blood thinners to prevent stroke, highlighting the importance of being vigilant and intermittently checking for AFib in this group," said Phelan. "For the majority of people, the benefits of both aerobic exercise, such as walking and strength training, such as working with weights, is strongly linked to a healthier heart, and this study should not discourage people from being physically active. Mild to moderate exercise reduces the risk of atrial fibrillation for most people."

Credit: 
American Heart Association

Visits to the dentist decline in old age, especially among minorities

Visits to the dentist drop significantly after adults turn 80, finds a new study by researchers at NYU Rory Meyers College of Nursing and the University of Hawai'i at Mānoa.

The study, published online in the journal Research on Aging, also highlights disparities in dental visits for U.S. adults by race and country of birth, with immigrants and racial and ethnic minorities less likely to access care.

Oral health is increasingly recognized as an essential part of healthy aging. It is closely related to overall health status and quality of life, and regular dental checkups can prevent oral diseases and maintain good oral health.

However, regularly seeing a dentist is a challenge for many Americans, especially older adults, racial and ethnic minorities, and immigrant populations. Older adults face barriers such as a lack of access to quality dental care, awareness of the importance of oral health, and dental insurance coverage. Medicare does not cover most dental care, and only 12 percent of Medicare beneficiaries report having at least some dental insurance from another source to help pay dental expenses. These roadblocks to dental care increase for racial and ethnic minorities and immigrants, who may experience racial discrimination and language barriers in healthcare settings.

"To promote oral health and close racial and ethnic gaps in oral health disparities, seeing a dentist regularly is critical," said Wei Zhang, PhD, professor and chair of the Department of Sociology at the University of Hawai'i at Mānoa and the study's first author. "Failure to engage in preventive dental care may lead to serious consequences such as tooth decay, pain, tooth loss, and inflammation."

In this study, the researchers examined how often people see a dentist as they age, focusing on U.S. adults 51 years and older, and explored variations by race and country of birth. While previous studies have looked at recent trends of dental care utilization among adults in the U.S., this study extends these efforts by using longitudinal data to focus on middle-aged and older adults across an extended period of time.

The researchers used data from the Health and Retirement Study (HRS), a longitudinal study from the University of Michigan that conducts interviews with a national sample of middle-aged and older adults. They analyzed rates of dental care utilization--measured by whether someone had seen a dentist in the past two years--for 20,488 study participants of different races and ethnicities, including 17,661 U.S.-born and 2,827 foreign-born individuals.

Seventy percent of adults had visited a dentist in the past two years, but this rate decreased significantly beginning around age 80. U.S.-born adults of all races and ethnicities were more likely to see a dentist (71 percent) than immigrants (62 percent). Interestingly, the gap in care between U.S.-born adults and immigrants shrunk as people aged, suggesting that age and acculturation may play a role in decreasing oral health disparities over time.

The researchers also found that White adults had higher rates of service utilization than Black and Hispanic adults, and while the rates of service utilization decreased with age for all groups, the rates of decline for Whites were slower than others.

"Our study went beyond prior research by confirming that racial and ethnic disparities were substantial and persistent as people became older, regardless of their birthplace and while adjusting for a wide range of factors. This finding is alarming as it indicates that some unmeasured factors beyond the scope of this study, such as oral health literacy, perception of need, barriers to access, and dissatisfaction with dental care, could play important roles in explaining the disparities in dental care as people age," said Bei Wu, PhD, Dean's Professor in Global Health at NYU Rory Meyers College of Nursing and co-director of the NYU Aging Incubator, as well as the study's senior author.

Credit: 
New York University

How nature builds hydrogen-producing enzymes

image: Thomas Happe (left) and Oliver Lampret aim at understanding the workings of hydrogen producing enzymes in detail.

Image: 
RUB, Kramer

A team from Ruhr-Universität Bochum and the University of Oxford has discovered how hydrogen-producing enzymes, called hydrogenases, are activated during their biosynthesis. They showed how the cofactor - part of the active centre and also the heart of the enzyme - is introduced inside.

Hydrogenases are of biotechnological interest as they are able to efficiently produce hydrogen. "In order to optimise them for an industrial application, we first need to understand the process of how the protein shell takes up and activates the chemical cofactor," says Professor Thomas Happe. A team led by Oliver Lampret and Thomas Happe from the Bochum-based Photobiotechnology Research Group published the results in the journal Proceedings of the National Academy of Sciences, PNAS for short, on 23 July 2019.

The researchers investigated the subgroup of [FeFe]-hydrogenases, which are the most efficient hydrogen producers. In nature, they can be found in green algae. Within their protein scaffold, the enzymes have an active centre, the so-called H-cluster, where the hydrogen is produced. It is comprised of two structural elements: a cluster containing four iron and four sulphur atoms, and the catalytic cofactor, which consists of two iron and two sulphur atoms. "This cofactor is the linchpin of the enzyme," explains Oliver Lampret.

Final step of biosynthesis

In nature, the cofactor is subsequently incorporated into the enzyme following the biosynthesis of the protein scaffold - a highly complex process. Only then is the hydrogenase catalytically active. The researchers clarified the precise sequence of the process using protein engineering, protein film electrochemistry and infrared spectroscopy.

The team showed that the negatively charged cofactor is specifically transported through a positively charged maturation channel into the interior of the enzyme before it is firmly anchored into the protein shell. Particularly flexible structural elements act as hinges here, ensuring that the protein folds differently and firmly envelopes and protects the integrated cofactor. The interaction of protein environment and cofactor is essential in order to stabilise the cofactor in its catalytic form.

"We assume that not only do [FeFe]-hydrogenases obtain their cofactor in this way but that the mechanism also occurs in other metalliferous enzymes," says Happe.

Credit: 
Ruhr-University Bochum

'Terminators' on the Sun trigger plasma tsunamis and the start of new solar cycles

image: This visualization of a computer model simulation shows a solar tsunami, which is initiated at the equator. As the tsunami travels toward the poles it buoys the toroidal magnetic fields (white lines) traveling deeper in the solar interior. As these bands are lifted to the surface, they erupt as sunspots on the solar surface.

Image: 
©UCAR Visualization: Mausumi Dikpati, NCAR

In a pair of new papers, scientists paint a picture of how solar cycles suddenly die, potentially causing tsunamis of plasma to race through the Sun's interior and trigger the birth of the next sunspot cycle only a few short weeks later.

The new findings provide insight into the mysterious timing of sunspot cycles, which are marked by the waxing and waning of sunspot activity on the solar surface. While scientists have long known that these cycles last approximately 11 years, predicting when one cycle ends and the next begins has been challenging to pin down with any accuracy. The new research could change that.

In one of the studies, which relies on nearly 140 years of solar observations from the ground and space, the scientists are able to identify "terminator" events that clearly mark the end of a sunspot cycle. With an understanding of what to look for in the run up to these terminators, the authors predict that the current solar cycle (Solar Cycle 24) will end in the first half of 2020, kicking off the growth of Solar Cycle 25 very shortly after.

In a second study, motivated by the first, scientists explore the mechanism for how a terminator event could trigger the start of a new sunspot cycle using a sophisticated computer model. The resulting simulations show that "solar tsunamis" could provide the connection and explain the Sun's remarkably rapid transition from one cycle to the next.

Both studies were led by the National Center for Atmospheric Research (NCAR).

"The evidence for terminators has been hidden in the observational record for more than a century, but until now, we didn't know what we were looking for," said NCAR scientist Scott McIntosh, who directs the center's High Altitude Observatory and worked on both studies. "By combining such a wide variety of observations over so many years, we were able to piece together these events and provide an entirely new look at how the Sun's interior drives the solar cycle."

The research was funded by the National Science Foundation, which is NCAR's sponsor, NASA's Living with a Star program, and the Indo-US Joint Networked R&D Center.

Flickers of light reveal mysteries

Sunspot cycles are born after solar minimum, a period when the face of the Sun is quiet. As the cycle continues, more and more sunspots emerge, first appearing at about 35 degrees latitude in both hemispheres and slowly marching toward the equator over a decade before they fade again into the next solar minimum. The rough midpoint of this progression is solar maximum, when sunspots are the most abundant.

Predicting the timing of sunspot evolution is a major scientific goal, in part because sunspot activity is tied to the solar storms that can disrupt Earth's upper atmosphere and affect GPS signals, power grids, and other critical technologies. But such predictions have proven challenging.

For example, the Sun is currently in a solar minimum. Scientist know the relative peace means that the current solar cycle is wrapping up, but it has been difficult to say whether the new cycle will begin in a few months or a few years. McIntosh and his colleagues think their studies can provide more clarity, both into the timing of cycles and also into what drives the cycles themselves.

The researchers began by studying the movement of coronal bright points - ephemeral flickers of extreme ultraviolet light in the solar atmosphere. By observing bright points, which occur even in the relative calm of a solar minimum, the scientists think they have gained a more complete view of the solar cycle than if they focused only on sunspot activity.

The bright points first appear at higher latitudes than sunspots (around 55 degrees) and migrate toward the equator at approximately 3 degrees latitude per year, reaching the equator after a couple decades. The paths traced by the bright points overlap with sunspot activity in the mid-latitudes (around 35 degrees) until they both reach the equator and disappear. This disappearance, which the researchers call a terminator event, is followed very shortly after with a large burst of bright point activity at the mid-latitudes, marking the beginning of the next sunspot cycle.

In the new study that identifies terminator events, published in the journal Solar Physics, the scientists corroborate the bright point observations with a number of other observations from a variety of spacecraft- and ground-observing facilities stretching back over 13 solar cycles.

"We were able to identify these terminators by looking at data from a whole range of different measures of solar activity - magnetic fields, spectral irradiance, radio flux - in addition to the bright points," said University of Maryland scientist Bob Leamon, a co-author of the paper who is also a researcher at NASA's Goddard Space Flight Center. "The results demonstrate that you really need to be able to step back and use all the available data to appreciate how things work - not just one spacecraft or one observation or one model."

Tsunami connections

McIntosh and his team have identified that coronal bright points allow them to better "see" the solar cycle unfolding. But why does the sunspot cycle start surging in the midlatitudes a few weeks after the terminator?

The paper on solar tsunamis, led by NCAR scientist Mausumi Dikpati and published in Scientific Reports, explores the possible mechanisms behind the observations. It suggests that coronal bright points are markers for the movement of the Sun's "toroidal magnetic fields," which wrap around the Sun like rubber bands stretching in the east-west direction and migrate slowly toward the equator over the same two decades.

When these toroidal magnetic fields bob to the surface, they create sunspots along with the bright points they were already producing. As they travel, they also act as magnetic dams, trapping plasma behind them. When the toroidal magnetic fields from the Sun's northern and southern hemispheres touch in the middle, their opposing charges cause their mutual annihilation, releasing the pent-up fluid behind them in a tsunami. This fluid rushes forward, collides, and then ripples backward, traveling toward the poles at a rate of about 300 meters per second.

As the solar tsunami reaches the Sun's mid-latitudes, it encounters the toroidal magnetic fields of the next cycle, which are already marching toward the equator (this progression is marked by the path of coronal bright points) but traveling deeper within the Sun's interior. The tsunami buoys those magnetic fields, lifting them toward the surface and producing the remarkable surge of bright points - and accompanying sunspot activity - that marks the beginning of the new sunspot cycle.

"We have observed the sunspot cycle for hundreds of years, but it's been a mystery what mechanism could transport a signal from the equator, where the cycle ends, to the Sun's mid-latitudes, where the next cycle begins, in such a relatively short amount of time," said Dikpati.

As a body, the research provides a new way of thinking about the workings of the solar interior that challenges some of the conventional thinking about processes on the Sun. Whether or not the research is on the right track - and could improve our predictive capabilities - will soon get its first test.

There are a number of instruments that are ideally suited to observe the inevitable end of the current solar cycle and the start of the next, according to the authors. These include the Parker Solar Probe, which launched last August, the STEREO-A spacecraft, the Solar Dynamics Observatory, the Daniel K. Inouye Solar Telescope, and other assets.

"In the next year, we should have a unique opportunity to extensively observe a terminator event as it unfolds and then to watch the launch of Sunspot Cycle 25," McIntosh said. "We believe the results, especially if the terminator arrives when predicted, could revolutionize our understanding of the solar interior and the processes that create sunspots and shape the sunspot cycle."

Credit: 
National Center for Atmospheric Research/University Corporation for Atmospheric Research

30,000+ US lives could be saved by reducing air pollution levels below current standard

image: These are maps of estimated premature mortality due to fine particulate matter.

Image: 
PLOS Magazine

PITTSBURGH--Research findings from the Center for Air Quality, Climate, and Energy Solutions (CACES) at Carnegie Mellon University show significant human health benefits when air quality is better than the current national ambient air quality standard. The estimate of lives that could be saved by further reduction of air pollution levels is more than thirty thousand, which is similar to the number of deaths from car accidents each year.

CACES' results were published this week in two related studies in the journals Environmental Health Perspectives and PLOS Medicine. The studies examined U.S. mortality related to fine particulate matter pollution (PM2.5), the complex mixture of chemicals that can penetrate deeply into the lungs, contributing to respiratory and cardiovascular disease and premature death. The current U.S. standard for PM2.5 is an annual average of 12 micrograms per cubic meter of air. The new findings indicate that there are significant public health benefits to improving air quality, even in locations where PM2.5 levels are below 12 micrograms per cubic meter.

"These findings are particularly relevant at a time when the EPA is planning to change how it calculates the benefits of cleaner air by dismissing any health benefits below the current standard," said Allen Robinson, director of CACES and professor of mechanical engineering at Carnegie Mellon. "These benefits are important to consider when evaluating efforts to tackle climate change, such as the Clean Power Plan."

Another key finding is the substantial health benefits that have occurred from clean-up efforts over the past two decades. For example, in parts of California and some southern states, these efforts are estimated to have increased life expectancy by 0.3 years. "Although there is more work to be done to continue to improve our air quality, it is important to celebrate the tremendous progress that has been made," added Robinson.

The two studies used very large, national sets of public data. "The fact that they are public data is very important because it means that independent research teams can replicate our results," said Robinson. "This satisfies legislators' demands for transparent science and ensures that there is admissible scientific evidence on which to base environmental regulations."

The study published in Environmental Health Perspectives used public data from 28 years of National Health Interview Surveys linked with the National Death Index to create a uniquely large, well-documented, representative cohort of 1.6 million U.S. adults. The study published in PLOS Medicine used data from the National Center for Health Statistics, examining 18.4 million cardiorespiratory deaths from 1999 to 2015. While the researchers involved in the two studies used different data sets and different methods, the outcomes of the studies are consistent.

"The ubiquitous and involuntary nature of exposures, and the broadly-observed effects across sub-populations, underscore the public-health importance of breathing clean air," said Arden Pope, professor of economics at Brigham Young University and the lead author of the Environmental Health Perspectives paper.

"In every county, some people are dying too early at current levels of air pollution, which would make further improvements a truly national priority," said Majid Ezzati, professor of global environmental health at Imperial College London and the senior author of the PLOS Medicine paper.

Credit: 
Carnegie Mellon University

Genome research shows that the body controls the integrity of heritable genomes

Scientists at the CECAD Cluster of Excellence in Aging Research of the University of Cologne have discovered that body cells which are in direct contact with the germ cells in the nematode Caenorhabditis elegans are responsible for controlling the stability of the genome in primordial germ cells (PGCs). All germ cells, including sperm and eggs, originate from primordial germ cells that form during early embryo development. Professor Dr. Björn Schumacher and his team at the UoC's Institute for Genome Stability in Aging and at CECAD discovered that somatic niche cells that surround the PGCs control their response to DNA damage. The study 'Somatic niche cells regulate the CEP-1/p53-mediated DNA damage response in primordial germ cells,' has now been published in Developmental Cell.

For more than hundred years, inheritance of genetic information was thought to be autonomously controlled by the germ cells, explaining why acquired traits cannot be genetically inherited. Scientists believed that mutations occurring only in germ cells were responsible for any heritable genetic changes - be it during evolution or as cause of genetic disorders. Schumacher and his team now challenge this assertion.

The DNA of an organism constantly gets damaged. Not only environmental influences, but also by-products of the body's energy metabolism damage the molecular structure of the genome in every cell. The scientists investigated how the genome integrity of PGCs is controlled. PGCs need to survey their genomes particularly rigorously because they give rise to all sperm or eggs of the organism. Damaged PGCs are particularly dangerous because they are hereditary and can lead to serious genetic disorders. PGCs thus need to stop dividing when their genomes are damaged until the DNA is repaired. Special niche cells are responsible for signalling to the PGCs that they need to stop dividing and repair before generating further germ cells. If they fail to do so, the PGCs might pass on dangerous mutations to the next generation.

To fulfil this important function, the niche cells are in intimate contact with the PGCs and instruct them whether to divide and generate germ cells or whether to stay inactive. 'This means that the body is responsible for controlling the integrity of heritable genomes,' Schumacher remarked. 'The parental body thus has somatic control over the integrity of PGC genomes, controlling the quality of the heritable genetic information.' Since studying PGCs in mammals is a complicated endeavour, Schumacher's team used C. elegans as a simple animal model to shed new light on to how PGCs control the integrity of the genomes they will pass on to their offspring.

These new insights open up new perspectives for understanding inheritance and causes of infertility.

Credit: 
University of Cologne

Artificial throat could someday help mute people 'speak'

image: A wearable artificial graphene throat, abbreviated here as 'WAGT,' can transform human throat movements into different sounds with training of the wearer.

Image: 
Adapted from <i>ACS Nano</i> <b>2019</b>, 10.1021/acsnano.9b03218

Most people take speech for granted, but it's actually a complex process that involves both motions of the mouth and vibrations of folded tissues, called vocal cords, within the throat. If the vocal cords sustain injuries or other lesions, a person can lose the ability to speak. Now, researchers reporting in ACS Nano have developed a wearable artificial throat that, when attached to the neck like a temporary tattoo, can transform throat movements into sounds.

Scientists have developed detectors that measure movements on human skin, such as pulse or heartbeat. However, the devices typically can't convert these motions into sounds. Recently, He Tian, Yi Yang, Tian-Ling Ren and colleagues developed a prototype artificial throat with both capabilities, but because the device needed to be taped to the skin, it wasn't comfortable enough to wear for long periods of time. So the researchers wanted to develop a thinner, skin-like artificial throat that would adhere to the neck like a temporary tattoo.

To make their artificial throat, the researchers laser-scribed graphene on a thin sheet of polyvinyl alcohol film. The flexible device measured 0.6 by 1.2 inches, or about double the size of a person's thumbnail. The researchers used water to attach the film to the skin over a volunteer's throat and connected it with electrodes to a small armband that contained a circuit board, microcomputer, power amplifier and decoder. When the volunteer noiselessly imitated the throat motions of speech, the instrument converted these movements into emitted sounds, such as the words "OK" and "No." The researchers say that, in the future, mute people could be trained to generate signals with their throats that the device would translate into speech.

Credit: 
American Chemical Society

New material for wearable devices able to restore conductivity developed

image: Contrary to typical materials, the electrical conductivity of which decreases when the shape of the materials is changed by an applied tensile strain, the new material developed by the KIST research team shows a dramatic increase in conductivity under a tensile strain of 3,500%.

Image: 
Korea Institute of Science and Technology (KIST)

The research team of researcher Hyunseon Seo and senior researcher Dr. Donghee Son of the Korea Institute of Science and Technology's (KIST, president: Byung-gwon Lee) Biomedical Research Institute and postdoctoral candidate Dr. Jiheong Kang and Professor Zhenan Bao of Stanford University (chemical engineering) announced a new material, developed via joint convergence research, that simultaneously possesses high stretchability, high electrical conductivity, and self-healability even after being subjected to severe mechanical strain.

Currently, interest in the development of wearable electronic devices is growing rapidly. Prior to this study, Dr. Donghee Son, Dr. Jiheong Kang, and Prof. Zhenan Bao developed a polymer material that is highly elastic, can self-heal without the help of external stimuli even when exposed to water or sweat, and has a mechanical strength similar to that of human skin, making it comfortable to wear for long periods of time. (Advanced Materials 30, 1706846, 2018)

In its most recent study, the KIST-Stanford research team developed a new material that can be utilized as an interconnect,* because it has the same properties as existing wearable materials as well as high levels of electrical conductivity and stretchability, which allow the stable transmission of electricity and data from the human body to electronic devices.

*Interconnect: a material that serves as a channel for the stable and accurate transmission of biosignals from the human body to an electronic device

The KIST-Stanford team dispersed silver micro-/nano-particles throughout the highly stretchable and self-healable polymer material to achieve a new design for a nanocomposite material with high stretchability and high electrical conductivity.

During tests, the material developed by the KIST team was utilized as an interconnect and attached to the human body to allow for the measurement of biometric signals in real time. The signals were then transmitted to a robotic arm, which successfully and accurately imitated (in real time) the movements of a human arm.

Contrary to typical materials, the electrical conductivity (and thus performance) of which decreases when the shape of the materials is changed by an applied tensile strain, the new material developed by the KIST research team shows a dramatic increase in conductivity under a tensile strain of 3,500 percent. In fact, electrical conductivity rose over 60-fold, achieving the highest conductivity level reported worldwide so far. Even if the material is damaged or completely cut through, it is able to self-heal, a property that is already gaining attention from academia.

The KIST team investigated phenomena that have not yet been studied in existing conductive materials. The phenomenon exhibited in the new material developed by the team is electrical "self-boosting," which refers to the self-improvement of electrical conductivity through the rearrangement and self-alignment of a material's micro-/nano-particles when the material is stretched. The team also discovered the mechanism of such dynamic behavior of micro-/nano-particles by using SEM and microcomputed tomography (μ-CT) analyses.

Seo said, "Our material is able to function normally even after being subjected to extreme external forces that cause physical damages, and we believe that it will be actively utilized in the development and commercialization of next-generation wearable electronic devices," while Son stated, "Because the outcome of this study is essentially the foundational technology necessary for the development of materials that can be used in major areas of the Fourth Industrial Revolution, such as medical engineering, electrical engineering, and robotics, we expect that it will be applicable to diverse fields."

Credit: 
National Research Council of Science & Technology

An apple carries about 100 million bacteria -- good luck washing them off

To the heroes among you who eat the whole apple: besides extra fiber, flavonoids and flavor, you're also quaffing 10 times as many bacteria per fruit as your core-discarding counterparts.

Is this a good thing? Probably. But it might depend on how your apples were grown.

Published in Frontiers in Microbiology, a new study shows that organic apples harbor a more diverse and balanced bacterial community - which could make them healthier and tastier than conventional apples, as well as better for the environment.

You are what you eat

Nowhere more so than your bowel.

"The bacteria, fungi and viruses in our food transiently colonize our gut," says study senior author Professor Gabriele Berg, of Graz University of Technology, Austria. "Cooking kills most of these, so raw fruit and veg are particularly important sources of gut microbes."

To help us choose our colonic colonists wisely, Berg's group analyzed the microbiome of one of the world's favorite fruits: the apple.

"83 million apples were grown in 2018, and production continues to rise," says Berg. "But while recent studies have mapped their fungal content, less is known about the bacteria in apples."

The researchers compared the bacteria in conventional store-bought apples with those in visually matched fresh organic ones. Stem, peel, flesh, seeds and calyx - the straggly bit at the bottom where the flower used to be - were analyzed separately.

Microbial diversity suggests organic apple advantage

Overall, the organic and conventional apples were occupied by similar numbers of bacteria.

"Putting together the averages for each apple component, we estimate a typical 240g apple contains roughly 100 million bacteria," reports Berg.

The majority of the bacteria are in the seeds, with the flesh accounting for most of the remainder. So, if you discard the core - for shame! - your intake falls to nearer 10 million. The question is: are these bacteria good for you?

When it comes to gut health, variety is the spice of life - and in this regard, organic apples seem to have the edge.

"Freshly harvested, organically managed apples harbor a significantly more diverse, more even and distinct bacterial community, compared to conventional ones," explains Berg. "This variety and balance would be expected to limit overgrowth of any one species, and previous studies have reported a negative correlation between human pathogen abundance and microbiome diversity of fresh produce."

Specific groups of bacteria known for health-affecting potential also weighed in favor of organic apples.

"Escherichia-Shigella - a group of bacteria that includes known pathogens - was found in most of the conventional apple samples, but none from organic apples. For beneficial Lactobacilli - of probiotic fame - the reverse was true."

And there may even be vindication for those who can "taste the difference" in organic produce.

"Methylobacterium, known to enhance the biosynthesis of strawberry flavor compounds, was significantly more abundant in organic apples; here especially on peel and flesh samples, which in general had a more diverse microbiota than seeds, stem or calyx."

Consumer choice

The results mirror findings on fungal communities in apples.

"Our results agree remarkably with a recent study on the apple fruit-associated fungal community, which revealed specificity of fungal varieties to different tissues and management practices," comments Birgit Wasserman, Berg protégé and lead author of the study.

Together the studies show that across both bacteria and fungi, the apple microbiome is more diverse in organically grown fruits. Since another study has shown that the apple fungal community is also variety-specific, the bacterial analyses too should be repeated in other cultivars.

"The microbiome and antioxidant profiles of fresh produce may one day become standard nutritional information, displayed alongside macronutrients, vitamins and minerals to guide consumers," suggests Wasserman. "Here, a key step will be to confirm to what extent diversity in the food microbiome translates to gut microbial diversity and improved health outcomes."

Credit: 
Frontiers

Private equity-backed acquisitions of dermatology practices

What The Study Did: This observational study describes the scope of private equity-backed acquisitions of dermatology practices in the United States.

Authors: Arash Mostaghimi, M.D., M.P.A., M.P.H., of Brigham and Women's Hospital in Boston and an associate editor of JAMA Dermatology, is the corresponding author.

(doi:10.1001/jamadermatol.2019.1634)

Editor's Note: The article contains conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

Credit: 
JAMA Network