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Press materials are now available for NUTRITION 2020 LIVE ONLINE, a dynamic virtual event showcasing new research findings and timely discussions on food and nutrition. The online meeting will be held June 1-4, 2020.

NUTRITION 2020 LIVE ONLINE is hosted by the American Society for Nutrition (ASN), the preeminent professional organization for nutrition research scientists and clinicians around the world. ASN's flagship meeting, Nutrition 2020, was canceled due to the impacts of COVID-19.

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NUTRITION 2020 LIVE ONLINE is free for all registrants. Simply create an account and get ready to enjoy streaming and on-demand content starting June 1.

Explore the full schedule, virtual abstract presentations, and on demand content to see all the exciting research topics that will be covered at NUTRITION 2020 LIVE ONLINE.

Materials are embargoed until June 1, 12 p.m. EDT, unless otherwise noted.

Leaders Call for 'Moonshot' on Nutrition Research (6/2, 2:30 p.m. EDT)
Science and policy experts urge coordinated research in face of national nutrition crisis

Experts Debate Saturated Fat Consumption Guidelines for Americans (6/3, 10:30 a.m. EDT)
Researchers weigh the evidence on saturated fat and heart disease

Dieting? Studies Weigh In on Opportunities and Risks
Progress and pitfalls in understanding the best way to lose excess weight

Study Pinpoints Top Sources of Empty Calories for Children and Teens
Children of all ages are consuming high amounts of added sugars and solid fats

Do Warning Labels Help People Choose Healthier Drinks?
Researchers examined more than 20 studies to find out if sugary drink warnings work

Playing Video Games Linked with Unhealthy Behaviors for College Men
Findings point to importance of educating gamers about healthy eating and exercise

Researchers Identify Seasonal Peaks for Foodborne Infections
New analysis approach could help identify when and where to conduct food safety inspections

Eating Whole Grains Could Help Lower Diabetes Risk
Large analysis looks at which types of carbohydrates affect risk of developing type 2 diabetes

Every major medical center in America sits on a gold mine. The data they hold about their patients and research participants could be worth millions of dollars to companies that would explore it for clues that could lead to new medicines, medical technologies, health apps and more.

Such efforts would take partnerships between industry and academic institutions -- which are already essential to medical innovation -- to a new level.

Before COVID-19 struck, major health systems had started selling the "mining rights" to troves of their health data and stored materials -- including details about patients' DNA found in samples of their blood or tissue. Current law allows this, as long as names and identifying details are stripped from patients' or research participants' individual records and samples before turning them over.

Now that the pandemic has squeezed hospitals' finances further, and increased the need for research on a grand scale, more medical centers may seek income from such "big data" agreements with industry partners. That's especially true for those whose patients also volunteer for in-house research studies.

But a new framework published in the New England Journal of Medicine could help them do so more responsibly, going beyond the minimum legal requirements and respecting patients by giving them more say in how their individual data may be used.

It was written by a team from Michigan Medicine, the University of Michigan's academic medical center -- one of the first to adopt such a framework. The authors lay out an approach already applied to thousands of U-M patients and research study volunteers, and dozens of projects.

"We believe our approach provides an ethical way to advance medical discovery and innovation while also respecting the trust patients and research participants put in the University of Michigan," says first author Kayte Spector-Bagdady, J.D., M.Bioethics, chief of the research ethics service of the Center for Bioethics & Social Sciences in Medicine and faculty at Michigan Medicine.

She wrote the piece with fellow members of a special U-M committee that oversees the university's process, including Sachin Kheterpal, M.D., M.B.A., associate dean for research information technology and a co-leader of U-M Precision Health, Ray Hutchinson, M.D., active emeritus professor of pediatrics and former associate dean for regulatory affairs, and Erin Kaleba, M.P.H., director of the office that oversees clinical research data.

Special consent

The crux of the system, launched in 2018, is an easy-to-understand informed consent document that research participants can choose to sign, in addition to the forms that they sign to take part in a U-M-run research project. The additional consent focuses on sharing their information, and any samples taken from them, outside the university.

They must first discuss the special outside-sharing consent form with research staff, who assess each participant's understanding of what giving the additional consent means.

The critical passage in the form reads: "You give permission to share your samples and information with researchers around the world including those working for companies. Researchers and their organizations may potentially benefit from the sale of the data or discoveries. You will not have rights to these discoveries or any proceeds from them."

More than half of research volunteers asked for such consent have given it. Once they do so, it opens up the possibility (with additional legal and ethical steps) for companies, foundations, medical specialty societies and nongovernmental agencies to access their samples and data to move innovation forward.

If their samples are being sought for a project with a specific company, they will be told about the project and company, though their consent applies to all approved industry use. They are told they can revoke their consent in future, stopping their data from being shared further.

But, if they don't consent, the samples of tissue and blood taken during their care and research participation, and the contents of their health record, will be marked as off-limits for sharing with industry. U-M teams may still use it for academic research, under a broader consent document and ethics board approvals.

A dedicated gatekeeper

The authors are all part of the other crucial part of U-M's approach: a committee that must review, approve and track any projects that involve patient data or specimen sharing with companies.

The article in NEJM lays out the decision process followed by the Michigan Medicine Human Data & Biospecimen Release Committee. It must review all proposals involving transfer of data or human materials to non-academic entities, mostly through partnerships between a U-M researcher and an outside company.

There are a few exceptions. Aggregated summaries of data, which do not disclose individual participant information, do not need to be reviewed. Data and specimens collected under industry-sponsored clinical trials that already include shared of information with the company that sponsored the study, do not need committee review either.

The committee, which meets every other week, has on average of three new proposals to review each time. Only a few have been rejected outright - mainly because the project proposed to use samples acquired before the new consent process, and there was no easy way to reach back to the people those samples had come from to ask for their consent.

The U-M framework does allow for the committee to grant exceptions, in rare cases, to the usual process.

For instance, if researchers and an outside partner are studying an "orphan" disease that affects few people, the committee weighs the importance of finding new treatment and prevention options against the individual participant's right to consent to industry use.

Past research has found that people who enroll in research are willing to accept some level of risk to themselves to help others with the same condition.

Though industry data-sharing doesn't carry risk of physical harm like a clinical trial might, it does carry a small risk that health data could be "re-identified" if matched with other types of available data sources, for instance in a databank of DNA from people who have taken ancestry DNA tests.

The committee even requires this level of consent when academic organizations are partnering with a commercial platform, such as an industry-supported disease registry.

Even in the face of COVID-19, and the pressing need to seek answers to a global pandemic, the framework is crucial, says Marschall Runge, M.D., Ph.D., U-M executive vice president for medical affairs and dean of the U-M Medical School.

"The temptation has never been greater to take shortcuts around health data protections to vie for huge federal grants or to develop and monetize intellectual property," says Runge. "That is why we have adopted our approach, and we hope it will serve as an example for others."

Syracuse, N.Y. - A new study published recently in ScienceDirect by researchers from Syracuse University and SUNY Upstate Medical University shows that people with intellectual and developmental disabilities (IDD) are more likely to die from COVID-19 than those without IDD.

According to the researchers, the disparity is likely related to a higher prevalence of comorbid diseases among those with IDD, and/or a higher percentage of people with IDD are living in congregate residential settings.

Their study, "Intellectual and Developmental Disability and COVID-19 Case-Fatality Trends: TriNetX Analysis," was published by ScienceDirect's Disability and Health Journal. The study included 30,282 people who were identified as COVID-19 positive in the TriNetX COVID-19 Research Network Platform.

"More attention is needed to this vulnerable health population in order to ensure their safety and well-being during this pandemic, including careful attention to the impact of public policies such as PPE prioritization and funding streams on the ability of residential service providers to guarantee quality care during this time," said researcher Scott Landes, an associate professor of sociology at Syracuse University's Maxwell School of Citizenship and Public Affairs and a research affiliate for the Lerner Center for Public Health Promotion.

The study was conducted by Landes and three researchers from SUNY Upstate Medical Center in Syracuse, N.Y.: Dr. Margaret Turk, professor of physical medicine and rehabilitation; Dr. Margaret Formica, associate professor of public health and preventative medicine and associate professor of urology; and Katherine Goss from the Disability & Health Research Team. Here is a more detailed look at their findings:

Every individual in this study had COVID-19, so rates are case-fatality rates that gave the researchers an idea of the severity of the disease among both groups. Among ages 0-17, for every 100 individuals with COVID-19, 1.6 with IDD died and less than one without IDD died. Among ages 18-74, for every 100 individuals with COVID-19, 4.5 with IDD died compared to 2.7 without IDD. Rates were similar for those 75 and over - for every 100 individuals with COVID-19, 21.1 with IDD died and 20.7 without IDD died.

"Based upon the case fatality rates we report among those ages 18-74, if 100,000 individuals with IDD contract COVID-19 - which is entirely possible in light of the estimates of the size of this population and the cumulative incidence rates we are seeing in our research - we would expect 4,500 to die," Landes said. "Comparatively, among 100,000 individuals without IDD, we would expect 2,700 to die. That would be an excess of 1,800 IDD deaths and in my mind that is unacceptable."

The researchers also found that individuals with IDD had a higher prevalence of comorbid circulatory, respiratory, and endocrine diseases across all age groups. While they could not test causality in this data, it is possible this partly explains the differences they found in case-fatality rates. Some of this difference may also be due to the higher percentage of individuals with IDD who reside in congregate settings - a characteristic the researchers could not account for in the study but are continuing to investigate.

The removal of a malignant brain tumor is something of a balancing act between removing as much tumor tissue as possible at the same time as protecting the healthy tissue. Since cancer cells infiltrate healthy brain tissue, it is often not possible to remove brain tumors completely during surgery. After an operation that removes as much of the tumor as possible, the prognosis can be improved by subsequent radiotherapy and chemotherapy, but a cure with conventional treatments is difficult to achieve.

Hope through immunotherapy

A team of researchers at the University of Zurich (UZH) and the University Hospital Zurich (USZ) has now found what types of immune cells are present in what numbers in different types of brain tumors. These very precise "tumor maps" are essential to gain a better understanding of the individual immune components in the tumor and to develop targeted immunotherapies that activate an immune defense reaction.

"Our immune system is very precise and efficient. The immune defense can eliminate individual tumor cells, while protecting healthy cells," explains Burkhard Becher of the Institute of Experimental Immunology at the University of Zurich. Immunotherapy can have astonishing success in treating some types of cancers - but with malignant brain tumors, immunotherapy has thus far yielded disappointing results. One of the reasons for this is previously, that the composition of the tumor tissue in brain tumors, specifically regarding to immune cells, was not explored with sufficient detail.

High-dimensional mass cytometry and complex computer algorithms

To characterize the immune cells in malignant brain tumors, the researchers analyzed tissue from the neurosurgery operating theaters of USZ using a method established at UZH called high-dimensional mass cytometry. This technology makes it possible to analyze millions of different cell types at the same time at the single cell level. The cells are characterized using numerous proteins on their surface and in the cell interior, which vary according to the cell type. The huge amount of data is then processed with complex, self-learning computer algorithms. "For every brain tumor, our technology gives an individual signature of the immune cells present. Similarities and differences between patients and tumor types can thus be compared," says Burkhard Becher.

Immune cell composition depends of the type of tumor

The study shows that it is primarily the tumor type which determines the kind, frequency and distribution of immune cells present in individual brain tumors. "Gliomas, which develop directly in the brain, look different from metastases of other tumors in the body which have spread into the brain. In gliomas too we can clearly differentiate between various sub-groups through the specific composition of the immune cells," add Ekaterina Friebel and Konstantina Kapolou, both PhD candidates in the collaborating research groups.

According to Marian Christoph Neidert, neurosurgeon at USZ, the results are not only helpful for better understanding the immunological mechanisms in brain tumors: "They also offer a basis for the development of immunotherapies that are tailored to the various types of brain tumors." The tumor tissue investigated in the study came from patients treated at the USZ Brain Tumor Center. However, further research work is still required before brain tumor patients will be able to benefit from the immunological findings.

Big theropod dinosaurs such as Allosaurus and Ceratosaurus ate pretty much everything--including each other, according to a new study, "High Frequencies of Theropod Bite Marks Provide Evidence for Feeding, Scavenging, and Possible Cannibalism in a Stressed Late Jurassic Ecosystem," published last month in the journal PLOS ONE.

"Scavenging, and even cannibalism, is pretty common among modern predators," said lead author Stephanie Drumheller, a paleontologist in the University of Tennessee, Knoxville's Department of Earth and Planetary Sciences. "Big theropods, like Allosaurus, probably weren't particularly picky eaters if it meant they got a free meal."

Researchers surveyed more than 2,000 bones from the Jurassic Mygatt-Moore Quarry, a 152-million-year-old fossil deposit in western Colorado, looking for bite marks. They found more than they were expecting.

There were theropod bites on the large-bodied sauropods whose gigantic bones dominate the assemblage, bites on the heavily armored Mymoorapelta, and lots of bites on theropods, too, especially the common remains of Allosaurus. There were hundreds of them, in frequencies far above the norm for dinosaur-dominated fossil sites.

Some were on meaty bones like ribs, but researchers discovered others on tiny toe bones, far from the choicest cuts. Pulled together, the data paints a picture of an ecosystem where dinosaur remains lay out on the landscape for months at a time--a stinky prospect, but one that gave a whole succession of predators and scavengers a turn at eating.

But why were there so many bites on the Mygatt-Moore bones? That question is a little harder to answer, at least without similar surveys from other dinosaur sites for comparison.

The Mygatt-Moore Quarry itself is a little unusual.

Volunteer members of the public have excavated most of the fossils found at the quarry. Julia McHugh, curator of paleontology with the Museums of Western Colorado and a co-author of the study, decided to continue this tradition of outreach by bringing students into the lab to help with the project. Now two of them, Miriam Kane and Anja Riedel, are co-authors on the new study as well.

"Mygatt-Moore is such a unique place," McHugh said. "Science happens here alongside hands-on STEM education with our dig program and volunteers."

Having so many marks on hand let the researchers really dig into details that are sometimes harder to study in smaller collections. For example, theropod teeth are serrated, and once in a while the tooth shape is reflected in the bite marks they make. Another co-author, Domenic D'Amore of Daemen College, had earlier figured out a way to translate those striated tooth marks into body size estimates.

"We can't always tell exactly what species were marking up the Mygatt-Moore bones, but we can say many of these marks were made by something big," D'Amore said. "A few may have been made by theropods larger than any found at the site before."

For more than 30 years, researches and others have worked the Mygatt-Moore Quarry intensively, but even after all that time, each season brings new discoveries in the field and in the lab. This snapshot of dinosaur behavior is proof that old bones can still hold scientific surprises.

EVANSTON, Ill. -- A Northwestern University-led team has developed a highly porous smart sponge that selectively soaks up oil in water.

With an ability to absorb more than 30 times its weight in oil, the sponge could be used to inexpensively and efficiently clean up oil spills without harming marine life. After squeezing the oil out of the sponge, it can be reused many dozens of times without losing its effectiveness.

"Oil spills have devastating and immediate effects on the environment, human health and economy," said Northwestern's Vinayak Dravid, who led the research. "Although many spills are small and may not make the evening news, they are still profoundly invasive to the ecosystem and surrounding community. Our sponge can remediate these spills in a more economic, efficient and eco-friendly manner than any of the current state-of-the-art solutions."

The research was published yesterday (May 27) in the journal Industrial Engineering and Chemical Research.

Dravid is the Abraham Harris Professor of Materials Science and Engineering at Northwestern's McCormick School of Engineering. Vikas Nandwana, a senior research associate in Dravid's laboratory, is the paper's first author.

Oil spill clean-up is an expensive and complicated process that often harms marine life and further damages the environment. Currently used solutions include burning the oil, using chemical dispersants to breakdown oil into very small droplets, skimming oil floating on top of water and/or absorbing it with expensive, unrecyclable sorbents.

"Each approach has its own drawbacks and none are sustainable solutions," Nandwana said. "Burning increases carbon emissions and dispersants are terribly harmful for marine wildlife. Skimmers don't work in rough waters or with thin layers of oil. And sorbents are not only expensive, but they generate a huge amount of physical waste -- similar to the diaper landfill issue."

The Northwestern solution bypasses these challenges by selectively absorbing oil and leaving clean water and unaffected marine life behind. The secret lies in a nanocomposite coating of magnetic nanostructures and a carbon-based substrate that is oleophilic (attracts oil), hydrophobic (resists water) and magnetic. The nanocomposite's nanoporous 3D structure selectively interacts with and binds to the oil molecules, capturing and storing the oil until it is squeezed out. The magnetic nanostructures give the smart sponge two additional functionalities: controlled movement in the presence of an external magnetic field and desorption of adsorbed components, such as oil, in a simulated and remote manner.

The OHM (oleophilic hydrophobic magnetic) nanocomposite slurry can be used to coat any cheap, commercially available sponge. The researchers applied a thin coating of the slurry to the sponge, squeezed out the excess and let it dry. The sponge is quickly and easily converted into a smart sponge (or "OHM sponge") with a selective affinity for oil.

Vinayak and his team tested the OHM sponge with many different types of crude oils of varying density and viscosity. The OHM sponge consistently absorbed up to 30 times its weight in oil, leaving the water behind. To mimic natural waves, researchers put the OHM sponge on a shaker submerged in water. Even after vigorous shaking, the sponge release less than 1% of its absorbed oil back into the water.

"Our sponge works effectively in diverse and extreme aquatic conditions that have different pH and salinity levels," Dravid said. "We believe we can address a giga-ton problem with a nanoscale solution."

"We are excited to introduce such smart sponges as an environmental remediation platform for selectively removing and recovering pollutants present in water, soil and air, such as excess nutrients, heavy metal contaminants, VOC/toxins and others," Nandwana said. "The nanostructure coating can be tailored to selectively adsorb (and later desorb) these pollutants."

The team also is working on another grade of OHM sponge that can selectively absorb (and later recover) excess dissolved nutrients, such as phosphates, from fertilizer runoff and agricultural pollution. Stephanie Ribet, a Ph.D. candidate in Dravid's lab and paper coauthor is pursuing this topic. The team plans to develop and commercialize OHM technology for environmental clean-up.

An international survey of Global Consortium on Climate and Health Education (GCCHE) membership found that the majority of members--health professions schools and programs, including medical, nursing, and public health--offer learning opportunities related to the health impacts of climate change, yet many also encountered challenges in instituting or developing curricula. The results of the survey provide a baseline assessment of the state of climate-health education internationally among health professions institutions. Results of the survey by Columbia University Mailman School of Public Health researchers appear in the journal JAMA Network Open.

The survey suggests there exist a range of educational offerings on climate-health, including sessions, courses, programs, or post-doctoral positions. Some schools have offered climate-health education for several years, some are just now adding content, and others do not include any content on the subject. While many schools are discussing adding climate-health educational offerings, there are still considerable gaps in offerings at many institutions as well as challenges that extend beyond the institutional level, such as political and funding priorities that might lead to lack of staff time and materials to support the training.

Conducted in 2017 and 2018, the survey was completed by 84 health professions institutions internationally. Among respondents, 63% offer climate-health education, most commonly as part of a required core course (76%). Sixty-one of 82 respondents (74%) reported additional climate-health offerings are under discussion, 42 of 59 (71%) encountered some challenges trying to institute the curriculum, and most have received a positive response to adding content mainly from students (39 of 58 (67%)), faculty (35 of 58 (60%)), and administration (23 of 58 (40%)).

The article's authors write that opportunities exist to facilitate the integration of climate-health curricula, such as working with students, faculty, and members of administration that are interested in this topic. In order to facilitate this integration, institutions can look to online resources, groups, and networks to provide guidance and information to develop curricula.

"We suggest that health professions schools include this content in their curricula and that awareness as well as financial support, resources, and expertise increase to help in its uptake," write study authors Brittany Shea, MA, Kim Knowlton, DrPH, and Jeffrey Shaman, PhD. "Climate change may be affecting health in a variety of ways with increasing consequences. Health professionals, including those in public health, nursing, and medical services, should be educated on how to prevent, mitigate, and respond to factors associated with climate change that may be associated with health in a negative way."

Brittany Shea is project director for GCCHE. Kim Knowlton is assistant professor of environmental health sciences and senior scientist with the Natural Resources Defense Council. Jeffrey Shaman directs GCCHE and the Columbia Mailman School Climate and Health Program; he is a professor of environmental health sciences.

An Irish mathematician, Dr Martin Kerin, from the School of Mathematics, Statistics and Applied Mathematics at NUI Galway, has had a research article published in the Annals of Mathematics, widely regarded as the top journal for pure mathematics in the world. The article, written in collaboration with Professor Sebastian Goette of the University of Freiburg and Professor Krishnan Shankar of the University of Oklahoma, resolves a question ?rst asked around 60 years ago on the geometrical properties of seven-dimensional objects which very closely resemble spheres.

The Annals of Mathematics was founded in 1884 and is published by the Department of Mathematics at Princeton University, in cooperation with the Institute for Advanced Study. Only around thirty articles are accepted each year and Dr Kerin is only the second ever Irish-based mathematician to have an article appear in the journal.

The article deals with the geometry of seven-dimensional exotic spheres. A standard sphere can be thought of as the set of all points at a ?xed distance from a given point and is the result of gluing two discs (the hemispheres) together along their boundaries. If the boundaries of the two discs were instead glued together in a more interesting way, one would obtain an exotic sphere: to the casual observer it appears like the standard sphere, but it is a very different object.

The discovery of exotic spheres by John Milnor in the late 1950's resulted in his being awarded the Fields' medal, the highest honour in mathematics. The subsequent quest to understand these spaces led to the development of much of modern topology and geometry. In the 1960's, mathematicians began to wonder how much the geometry of exotics spheres, that is the shape, resemble that of the standard spheres. A common measurement of shape is the curvature, the same quantity used in Einstein's general theory of relativity to describe gravity and the shape of the universe. The standard sphere is the basic example of a positively curved space, and previous work had shown that some of the seven-dimensional exotic spheres admit nonnegative curvature. In this article, a new construction of the seven-dimensional exotic spheres was discovered, which allows one to conclude that, in fact, all of these spaces admit non-negative curvature.

Dr Kerin said: "It is a tremendous honour, and a dream come true, to have our article appear in the Annals and to see our names listed among many of the greatest mathematicians in history. I am fortunate to have two fantastic collaborators in this project, each of us bringing different strengths to the table. Some of the basic ideas in the paper had been ?oating around in the back of my mind for around a decade, and we were able to successfully apply these basic ideas to a long-standing open problem. We are very proud of our achievement, but it is possibly even more pleasing that this project has thrown up many other interesting questions. We will likely be busy with this line of research for many years to come."

The article can be found at https://annals.math.princeton.edu/2020/191-3/p03.

FAIRFAX, Va. -- New research published today in the Journal of NeuroInterventional Surgery (JNIS) shows ischemic stroke patients are arriving to hospitals and treatment centers an average of 160 minutes later during the COVID-19 pandemic, as compared with a similar timeframe in 2019. These delays, say stroke surgeons from the Society of NeuroInterventional Surgery (SNIS), are impacting both survival and recovery.

The first study to confirm suspected stroke patient avoidance assessed 710 patients presenting with acute ischemic strokes at 12 stroke centers across six states. It compared the period of February and March 2019 (the baseline period) to February 2020 (the "pre-COVID-19" period) and March 2020 (the "COVID-19" period). In addition to the delay in treatment, the study also found a marked decrease in overall reported stroke patients, from 223 to 167, in these same treatment centers from February to March 2020 with the onset of the COVID-19 pandemic.

Neurointerventionalists with the Get Ahead of Stroke campaign say that in the case of the most serious strokes -- known as an emergent large vessel occlusions (ELVO) -- up to two million brain cells die each minute. The longer patients wait before treatment, the greater the impact the stroke will have -- potentially paralyzing them for life, or worse. Additionally, for every minute lost before receiving appropriate care, there is an associated medical cost of $1,000 for short- and long-term care. A 160-minute delay amounts to the loss of 320 million brain cells and $160,000 in additional medical costs.

"When it comes to stroke treatment, every minute counts. My colleagues and I have been devastated to see patients arriving at the hospital too late for us to help them," said the study's lead author Dr. Clemens Schirmer who is based at Geisinger Medical Center in Danville, Pennsylvania. "Our findings indicate a dire need for public education to address COVID-19 related fears to ensure people with stroke symptoms seek the lifesaving care they need without delay."

"Stroke care teams across the country have implemented protocols to safeguard patients from COVID-19," said Dr. Richard P. Klucznik, president of SNIS. "A stroke will not go away if you ignore it, and delaying treatment could eliminate your chance for recovery. It's critical to pay attention to any symptoms of stroke and call 911 right away."

Get Ahead of Stroke is a national public education and advocacy campaign designed to improve systems of care for stroke patients. Founded in 2016 by the Society of NeuroInterventional Surgery (SNIS), the campaign is currently working with its partners to ensure that the COVID-19 pandemic does not deter stroke patients from getting the lifesaving care they deserve.

May 28, 2020 - For a while now, some plastic surgeons have been using stem cells to treat aging, sun-damaged skin. But while they've been getting good results, it's been unclear exactly how these treatments - using adult stem cells harvested from the patient's own body - work to rejuvenate "photoaged" facial skin.

A new microscopic-level study provides the answer: within a few weeks, stem cell treatment eliminates the sun-damaged elastin network and replacing them with normal, undamaged tissues and structures - even in the deeper layers of skin.

Injection of the patient's own mesenchymal stem cells (MSCs) is "appropriate, competent and sufficient to elicit the full structural regeneration of the sun-aged skin," according to the report by Dr. Luis Charles-de-Sá, MD, of Universidade Federal do Rio de Janeiro, Brazil, Natale Gontijo-Amorim, MD and Gino Rigotti, MD of Verone-Italy University and colleagues. Their study appears in the June issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS).

The researchers assessed the cellular- and molecular-level effects of MSC treatment on sun-damaged (photoaged) facial skin. All 20 patients in the study, average age 56 years, were scheduled for facelift surgery. The patients lived in northeast Brazil, a region where intense sun exposure is expected.

For each patient, a small sample of fat cells from the abdomen was processed to create patient-specific MSCs. The cultured stem cells were injected under the skin of the face, in front of the ear. When the patients underwent facelift surgery three to four months later, skin samples from the stem cell-treated area were compared to untreated areas.

Histologic and structural under the microscope analysis demonstrated that MSC treatment led to improvement in overall skin structure. Treated areas showed "partial or extensive reversal" of sun-related damage to the skin's stretchy elastin network - the main skin structure affected by photoaging. In the layer immediately beneath the skin surface, the stem cell-treated areas showed regeneration of a new, fully organized network of fiber bundles and dermal ECM remodeling changes.

In the deeper skin layer, "tangled, degraded, and dysfunctional" deposits of sun-damaged elastin were replaced by a normal elastin fiber network. These changes were accompanied by molecular markers of processes involved in absorbing the abnormal elastin and development of new elastin.

The findings suggested that stem cells triggered each of the many cellular- and molecular-level pathways involved in skin repair and regeneration. Use of the patient's own fat-derived MSCs "may be a relevant proposal for the anti-ageing action in regeneration of photodamaged human skin," Dr. Charles-de-Sá and colleagues write.

"The researchers conclude that stem-cells can lead to regeneration of sun-aged skin," according to a video commentary by Plastic and Reconstructive Surgery Editor-in-Chief Rod J. Rohrich, MD. In his video, Dr. Rohrich walks viewers through the dramatic changes in the microscopic appearance of skin samples obtained before and after MSC treatment.

"The re-building of structures below the surface translates to true improvements to the strength and appearance of the facial dermis," Dr. Rohrich adds. He emphasizes that patients interested in stem-cell treatment for aging, sun-damaged skin should discuss their options with a Board-certified plastic surgeon.

In October 2016, a cyberattack temporarily took down Amazon, Reddit, Spotify and Slack for users along the U.S.'s East Coast. "Mirai," a botnet of hacked security cameras and Internet routers, aimed a flood of junk traffic at the servers of Dyn, a company that provides the global directory (or phonebook) for the web known as the Domain Name System or DNS.

Now researchers at Tel Aviv University and the Interdisciplinary Center (IDC) of Herzliya say that a weakness in the DNS could have brought about an attack of a much larger scale.

In their new study, which will be presented at the USENIX Security Conference in August 2020, the research group, co-led by Prof. Yehuda Afek of TAU's Blavatnik School of Computer Science, Blavatnik Interdisciplinary Cyber Research Center and the Checkpoint Institute and Prof. Anat Bremler-Barr, Vice Dean of IDC's Efi Arazi School of Computer Science, together with TAU doctoral student Lior Shafir, provide new details of a technique that could have allowed a relatively small number of computers to carry out DDoS (distributed denial of service) attacks on a massive scale, overwhelming targets with false requests for information until they were thrown offline.

As early as February, the researchers alerted a broad collection of companies responsible for the Internet's infrastructure to their findings. The researchers say those firms, including Google, Microsoft, Cloudflare, Amazon, Dyn (now owned by Oracle), Verisign, and Quad9, have all updated their software to address the problem, as have several makers of the DNS software those companies use.

Through joint research projects, Prof. Afek and Prof. Bremler-Barr have already stopped hundreds of thousands of DDoS cyberattacks over the last two decades, starting with the design of the first DDoS attacks scrubber server at Riverhead Networks, a company they co-founded with Dr. Dan Touitou in 2001.

"The DNS is the essential Internet directory," explains Prof. Bremler-Barr. "In fact, without the DNS, the Internet cannot function. As part of a study of various aspects of the DNS, we discovered to our surprise a very serious breach that could attack the DNS and disable large portions of the network."

The new threatening DDoS technique, which the researchers dubbed "NXNSAttack" (Non Existent Name Server Attack) takes advantage of vulnerabilities in common DNS software. DNS converts the domain names you click or type into the address bar of your browser into IP addresses. But the NXNSAttack can cause an unwitting DNS server to perform hundreds of thousands of requests in response to just one hacker's request.

"The attack in 2016 used over 1M IoT devices, whereas here we see the same impact with only a few hundred," adds Prof. Afek. "We are talking about a major amplification, a major cyberattack that could disable critical parts of the internet."

The way it works is that when a client machine tries to reach a certain resource on the Internet, it issues a request with the name of the resource to a resolver type DNS server, which is in charge of translating the requested name into an IP address. In order to find the required IP address, the resolver goes into an exchange of messages with several DNS servers of another type, called "authoritative." The authoritative servers redirect the resolver from one to the other, essentially telling it to "go and ask that one" until the resolver reaches an authoritative server that knows the final answer -- the requested IP address.

"To mount the NXNSattack," continues Prof. Afek, "an attacker either acquires for a negligible price or simply penetrates an authoritative server, which would redirect the resolver to send an enormous number of requests to the authoritative servers. This happens while the resolver is trying to answer the particular request that the attacker has crafted.

"The attacker sends such a request multiple times over a long period of time, which generates a tsunami of requests between the DNS servers, which are subsequently overwhelmed and unable to respond to the legitimate requests of actual legitimate users."

Mr. Shafir explains further: "A hacker that discovered this vulnerability would have used it to generate an attack targeting either a resolver or an authoritative DNS server in particular locations in the DNS system. In either case, the attack server would be incapacitated and its services blocked, unable to function due to the overwhelming number of requests it got. It would prevent legitimate users from reaching the resources on the Internet they sought."

The research for the study formed part of Mr. Shafir's PhD work; he built a set up with an authoritative server, on which he simulated an attack on the servers, generating a tsunami of requests between the servers, incapacitating them as a result.

"Our discovery has prevented major potential damage to web services used by millions of users worldwide," concludes Prof. Yehuda Afek. "The 2016 cyberattack, which is considered the greatest in history, knocked down much of the Internet in the U.S. But an attack like the one we now prevented could have been more than 800 times more powerful."

During early childhood, girls with autism tend to show greater reduction and less rise in their autism symptom severity than boys with autism, a UC Davis MIND Institute study has found.

Early childhood is a period of substantial brain growth with critical ability for learning and development. It also is the typical time for an initial diagnosis of autism and the best time for early intervention. In the U.S., about 1 in 54 children has been identified with autism spectrum disorder (ASD), with four times as many boys with ASD as girls.

Previous studies indicated inconsistent results in terms of changes in autism severity during childhood. The general sense was that the severity of autism at diagnosis would last a lifetime.

The MIND Institute's study, published May 14 in the Journal of Autism and Developmental Disorders, evaluated changes in symptom severity in early childhood and the potential factors associated with those changes. It included 125 children (89 boys and 36 girls) with ASD from the Autism Phenome Project (APP), a longitudinal project in its 14th year at the MIND Institute. The children received substantial community-based autism intervention throughout their childhood.

The researchers used a 10-point severity measure called the ADOS Calibrated Severity Score (CSS) derived from the Autism Diagnostic Observation Schedule (ADOS), the gold standard assessment tool in autism research. They computed a severity change score for participants as the difference between their ADOS CSS scores at age 6 and at age 3. A change of two points or more was considered a significant change in symptom severity.

Change in severity of autism symptoms and optimal outcome

The study classified participants based on their severity change score into a Decreased Severity Group (28.8%), a Stable Severity Group (54.4%) and an Increased Severity Group (16.8%). One key finding was that children's symptom severity can change with age. In fact, children can improve and get better.

"We found that nearly 30% of young children have less severe autism symptoms at age 6 than they did at age 3. In some cases, children lost their autism diagnoses entirely," said David Amaral, a distinguished professor of psychiatry and behavioral sciences, faculty member at the UC Davis MIND Institute and senior author on the study.

"It is also true that some children appear to get worse," Amaral said. "Unfortunately, it is not currently possible to predict who will do well and who will develop more severe autism symptoms and need different interventions."

Optimal outcome is a standard achieved when someone previously diagnosed with ASD no longer meets autism diagnostic criteria due to loss of autism symptoms. In this study, seven participants (four girls and three boys) had an ADOS CSS below the ASD cutoff at age 6, potentially indicating optimal outcome. Children showing decreasing symptom severity had better adaptive skills in multiple domains compared to those in the stable or increased severity groups.

Girls with autism and camouflaging as a coping strategy

Girls and boys might be characterized with different manifestations of autism symptoms. Girls might show better developmental results than boys in cognition, sociability and practical communication skills.

"We found that girls with autism decrease in severity more than boys and increase in severity less than boys during early childhood," said Einat Waizbard-Bartov, a graduate researcher at the MIND Institute and the first author of the paper.

One possible explanation for this difference is the girls' ability to camouflage or hide their symptoms, according to Waizbard-Bartov. Camouflaging the characteristics of autism includes masking one's symptoms in social situations. This coping strategy is a social compensatory behavior more prevalent in females diagnosed with ASD compared to males with ASD across different age ranges, including adulthood.

"The fact that more of the girls appear to have decreased in autism severity may be due to an increasing number of girls compared to boys who, with age, have learned how to mask their symptoms," Waizbard-Bartov said. "We will explore this possibility in future studies."

IQ, initial severity and change in autism severity

The study also found that IQ had a significant relationship with change in symptom severity. Children with higher IQs were more likely to show a reduction in ASD symptoms.

"IQ is considered to be the strongest predictor of symptom severity for children with autism," Waizbard-Bartov said. "As IQ scores increased from age 3 to age 6, symptom severity levels decreased."

The researchers could not identify a relationship between early severity levels and future symptom change. Surprisingly, the group of children with increased symptom severity at age 6 showed significantly lower severity levels at age 3, and their severity scores were less variable than the other groups.

The study raises several issues for further investigation, such as the relationships between IQ, initial severity level, and type and intensity of intervention received, in relation to symptom change over time.

Astronomers using NASA's Hubble Space Telescope are finding that planets have a tough time forming in the rough-and-tumble central region of the massive, crowded star cluster Westerlund 2. Located 20,000 light-years away, Westerlund 2 is a unique laboratory to study stellar evolutionary processes because it's relatively nearby, quite young, and contains a large stellar population.

A three-year Hubble study of stars in Westerlund 2 revealed that the precursors to planet-forming disks encircling stars near the cluster's center are mysteriously devoid of large, dense clouds of dust that in a few million years could become planets.

However, the observations show that stars on the cluster's periphery do have the immense planet-forming dust clouds embedded in their disks. Researchers think our solar system followed this recipe when it formed 4.6 billion years ago.

So why do some stars in Westerlund 2 have a difficult time forming planets while others do not? It seems that planet formation depends on location, location, location. The most massive and brightest stars in the cluster congregate in the core, which is verified by observations of other star-forming regions. The cluster's center contains at least 30 extremely massive stars, some weighing up to 80 times the mass of the Sun. Their blistering ultraviolet radiation and hurricane-like stellar winds of charged particles blowtorch disks around neighboring lower-mass stars, dispersing the giant dust clouds.

"Basically, if you have monster stars, their energy is going to alter the properties of the disks around nearby, less massive stars," explained Elena Sabbi, of the Space Telescope Science Institute in Baltimore and lead researcher of the Hubble study. "You may still have a disk, but the stars change the composition of the dust in the disks, so it's harder to create stable structures that will eventually lead to planets. We think the dust either evaporates away in 1 million years, or it changes in composition and size so dramatically that planets don't have the building blocks to form."

The Hubble observations represent the first time that astronomers analyzed an extremely dense star cluster to study which environments are favorable to planet formation. Scientists, however, are still debating whether bulky stars are born in the center or whether they migrate there. Westerlund 2 already has massive stars in its core, even though it is a comparatively young, 2-million-year-old system.

Using Hubble's Wide Field Camera 3, the researchers found that of the nearly 5,000 stars in Westerlund 2 with masses between 0.1 to 5 times the Sun's mass, 1,500 of them show fluctuations in their light as the stars accrete material from their disks. Orbiting material clumped within the disk would temporarily block some of the starlight, causing brightness fluctuations.

However, Hubble detected the signature of such orbiting material only around stars outside the cluster's packed central region. The telescope witnessed large drops in brightness for as much as 10 to 20 days around 5% of the stars before they returned to normal brightness. They did not detect these dips in brightness in stars residing within four light-years of the center. These fluctuations could be caused by large clumps of dust passing in front of the star. The clumps would be in a disk tilted nearly edge-on to the view from Earth. "We think they are planetesimals or structures in formation," Sabbi explained. "These could be the seeds that eventually lead to planets in more evolved systems. These are the systems we don't see close to very massive stars. We see them only in systems outside the center."

Thanks to Hubble, astronomers can now see how stars are accreting in environments that are like the early universe, where clusters were dominated by monster stars. So far, the best known nearby stellar environment that contains massive stars is the starbirth region in the Orion Nebula. However, Westerlund 2 is a richer target because of its larger stellar population.

"Hubble's observations of Westerlund 2 give us a much better sense of how stars of different masses change over time, and how powerful winds and radiation from very massive stars affect nearby lower-mass stars and their disks," Sabbi said. "We see, for example, that lower-mass stars, like our Sun, that are near extremely massive stars in the cluster still have disks and still can accrete material as they grow. But the structure of their disks (and thus their planet-forming capability) seems to be very different from that of disks around stars forming in a calmer environment farther away from the cluster core. This information is important for building models of planet formation and stellar evolution."

This cluster will be an excellent laboratory for follow-up observations with NASA's upcoming James Webb Space Telescope, an infrared observatory. Hubble has helped astronomers identify the stars that have possible planetary structures. With Webb, researchers can study which disks around stars are not accreting material and which disks still have material that could build up into planets. This information on 1,500 stars will allow astronomers to map a path on how star systems grow and evolve. Webb also can study the chemistry of the disks in different evolutionary phases and watch how they change, and help astronomers determine what influence environment plays in their evolution.

NASA's Nancy Grace Roman Space Telescope, another planned infrared observatory, will be able to perform Sabbi's study on a much larger area.? Westerlund 2 is just a small slice of an immense star-formation region. These vast regions contain clusters of stars with different ages and different densities. Astronomers could use Roman Space Telescope observations to start to build up statistics on how a star's characteristics, like its mass or outflows, affect its own evolution or the nature of stars that form nearby. The observations could also provide more information on how planets form in tough environments.

DALLAS, May 28, 2020 -- Type 2 diabetes (T2D) affects American Indians and Alaska Natives at approximately three times the rate of white Americans and is closely linked to the disproportionately high rates of cardiovascular diseases such as heart attacks and strokes, according to the American Heart Association Scientific Statement "Cardiovascular Health in American Indians and Alaska Natives," published today in the Association's flagship journal Circulation.

The statement provides an overview for the general public, health care providers and policy makers about the major cardiovascular challenges faced by this population group who have one of the highest rates of cardiovascular disease in the United States.

American Indians and Alaska Natives develop cardiovascular diseases at earlier ages than white Americans. Heart disease rates are approximately 50% higher among the 5.2 million Americans who self-identify as American Indian and Alaska Native, compared to white Americans. And, more than one-third of deaths attributed to cardiovascular disease occur before the age of 65.

Obesity, a major contributor to T2D, is an epidemic among American Indians and Alaska Natives - it is estimated that 30-40% of American Indians have obesity. The Strong Heart Study, cited in the statement, found that some of the risk for obesity and diabetes is genetically inherited. Given this propensity, it is important for health care professionals to assess coronary heart disease risk and continually monitor for coronary heart disease in American Indians and Alaska Natives.

"There are urgent cardiovascular health risks for American Indians and Alaska Natives that health care professionals and policy makers should not ignore. We strongly encourage patients, health care professionals and most importantly, community leaders to take steps to prevent and fight cardiovascular disease," said Khadijah Breathett, M.D., M.S., FAHA, chair of the writing committee for the Scientific Statement, assistant professor of medicine in the division of cardiology at the University of Arizona, and advanced heart failure and transplant cardiologist at Banner - University Medical Center in Tucson, Arizona.

The social determinants of health facing American Indians and Alaska natives are longstanding and complex, and access to health care is limited. In 2017, 19% did not have health insurance. The federal health program, Indian Health Service, provides health care for 1.6 million American Indians and Alaska Natives. However, that accounts for less than one-third of the total American Indian and Alaska Native population in the U.S.

Historical events such as displacement, war, infectious disease, unfulfilled agreements and decimation of tribal lands by the U.S. government in the 1800s created a cultural mistrust among many American Indians and Alaska Natives. Being forced to move from their native lands and living in rural areas without access to proper health care contribute to the issue. Currently, 21% of American Indians live below the federal poverty line.

"Racial and ethnic minority groups in the U.S. have suffered from inequitable policies for hundreds of years. These policies have contributed to mistrust in the traditional health care system. The most effective way to create change is through restructuring of inequitable policies and empowerment of communities," said Breathett.

The statement notes that the most effective interventions by health care professionals start by seeking the support of community leaders, building a relationship with the community, assessing barriers and resources for individuals, creating a method of public communication and developing an action plan for progress.

Nearly 32% of American Indians and Alaska Natives use tobacco, a rate almost twice as high as other ethnic populations in the U.S. Anti-tobacco intervention methods, such as media campaigns and modified smoking policies, are less effective than culturally adapted methods of community reinforcement.

In addition to individual risk factors, there are others that need to be addressed at the policy level, including the exposure to toxic metals due to groundwater contamination, which is particularly high in the Midwest and Southwest. Toxic metal exposure to arsenic and cadmium are associated with increased development of atherosclerosis as well as increased total cholesterol levels in multiple American Indian populations. Atherosclerosis is the slow narrowing of arteries that underlies most heart attacks and strokes.

Physician bias influences healthcare delivery among racial and ethnic minorities. Experiences of discrimination and microaggressions in the healthcare setting have correlated with worse physical and mental health among American Indians with chronic diseases. Implicit bias training may help reduce the impact of bias in decision-making between healthcare professionals and American Indian and Alaska Native patients.

Shared decision-making between a patient and their health care professional has been a longstanding tradition among some American Indians and Alaska Natives. Many participate in community-talking circles in which everyone in the group has the right to provide uninterrupted perspectives. Talking circles have been instrumental in providing education and empowering the American Indian and Alaska Native community to manage T2D.

The greatest risk factor for cardiovascular disease among American Indians and Alaska Natives is T2D, which is exacerbated by the social determinants of health experienced by this group. Community-based, culturally appropriate interventions are necessary to reduce T2D risk by encouraging physical activity and weight loss; controlling cardiovascular disease risk factors, such as high cholesterol and high blood pressure; and promoting tobacco cessation.

"Health care providers must individualize care by identifying the individual patient's needs and matching them to the appropriate resources such as community-based interventions. We encourage patients, healthcare professionals and community stakeholders to learn the risk factors for cardiovascular disease and take steps to fight cardiovascular disease before it starts. We are all in this together," said Breathett.

Researchers at the University of Copenhagen's Department of Nutrition, Exercise and Sports have demonstrated that physical activity prompts a clean-up of muscles as the protein Ubiquitin tags onto worn-out proteins, causing them to be degraded. This prevents the accumulation of damaged proteins and helps keep muscles healthy.

Physical activity benefits health in many ways, including the building and maintenance of healthy muscles, which are important for our ability to move about normally, as well as to fulfill the vital role of regulating metabolism. As most of the carbohydrate that we eat is stored in muscle, our muscles are extremely important for regulating metabolism.

An intense bike ride boosts Ubiquitin activity

Maintaining muscular function is essential. Part of our ability to do so depends upon proteins - the building blocks of muscles - being degraded when worn-out and eliminated in a kind of clean up process that allows them to be replaced by freshly synthesized proteins.

Now, Danish researchers - in collaboration with research colleagues at the University of Sydney, Australia - have demonstrated that a single, intense, roughly 10-minute bicycle ride results in a significant increase in the activity of Ubiquitin, the 'death marker protein' and a subsequent intensification of the targeting and removal of worn-out proteins in muscles. This paves the way for an eventual build-up of new proteins:

"Muscles eliminate worn-out proteins in several ways," explains Professor Erik Richter of the Section for Molecular Physiology at UCPH's Department of Nutrition, Exercise and Sports. He continues:

"One of these methods is when Ubiquitin, "the death-marker", tags a protein in question. Ubiquitin itself is a small protein. It attaches itself to the amino acid Lysine on worn-out proteins, after which the protein is transported to a Proteasome, which is a structure that gobbles up proteins and spits them out as amino acids. These amino acids can then be reused in the synthesis of new proteins. As such, Ubiquitin contributes to a very sustainable circulation of the body's proteins."

Why physical activity is healthy

While extensive knowledge has been accumulated about how muscles regulate the build-up of new proteins during physical training, much less is known about how muscle contractions and exercise serve to significantly clean-up worn-out proteins. According to Professor Bente Kiens, another project participant: "The important role of Ubiquitin for 'cleaning-up' worn-out proteins in connection with muscular activity was not fully appreciated. Now we know that physical activity increases Ubiquitin tagging on worn-out proteins."

Professor Jørgen Wojtaszewski, a third Danish project participant, explains that their findings serve to strengthen the entire foundation for the effect of physical activity: "Basically, it explains part of the reason why physical activity is healthy. The beauty is that muscle use, in and of itself , is what initiates the processes that keep muscles 'up to date', healthy and functional."

There remains a great amount of knowledge that would be interesting to delve deeper into, as very little is known about how different training regimens, gender, diet and genetic background impact the process and thus, the possibility of influencing optimal muscle function.