Culture

After a decade of searching, the UC San Francisco scientists who identified the only human gene known to promote "natural short sleep" -- lifelong, nightly sleep that lasts just four to six hours yet leaves individuals feeling fully rested -- have discovered a second.

"Before we identified the first short-sleep gene, people really weren't thinking about sleep duration in genetic terms," said Ying-Hui Fu, PhD, professor of neurology and a member of the UCSF Weill Institute for Neurosciences. Fu led the research teams that discovered both short sleep genes, the newest of which is described in a paper published August 28, 2019 in the journal Neuron.

According to Fu, many scientists once thought that certain sleep behaviors couldn't be studied genetically. "Sleep can be difficult to study using the tools of human genetics because people use alarms, coffee and pills to alter their natural sleep cycles," she said. These sleep disruptors, the thinking went, made it difficult for researchers to distinguish between people who naturally sleep for less than six hours and those who do so only with the aid of an artificial stimulant.

Natural short sleepers remained a mystery until 2009, when a study conducted by Fu's team discovered that people who had inherited a particular mutation in a gene called DEC2 averaged only 6.25 hours of sleep per night; study participants lacking the mutation averaged 8.06 hours. This finding provided the first conclusive evidence that natural short sleep is, at least in some cases, genetic. But this mutation is rare, so while it helped explain some natural short sleepers, it couldn't account for all of them.

"Sleep is complicated," said UCSF's Louis Ptáček, MD, the John C. Coleman Distinguished Professor in Neurodegenerative Diseases and co-senior author of the new study. "We didn't think there was just one gene or one region of the brain telling our bodies to sleep or wake." Ptáček and Fu reasoned that there had to be other, as yet undiscovered, causes of short sleep.

As the new study describes, a breakthrough came when the researchers identified a family that included three successive generations of natural short sleepers, none of whom harbored the DEC2 mutation. The researchers used gene sequencing and a technique known as linkage analysis, which helps scientists pinpoint the exact chromosomal location of mutations associated with a particular trait, to comb through the family's genome. Their efforts uncovered a single-letter mutation in a gene known as ADRB1 that, like the mutation in DEC2, was associated with natural short sleep.

Eager to understand how the newly discovered mutation might lead to short sleep, the researchers performed a series of experiments in lab-grown cells and in mice that had been genetically engineered to harbor an identical mutation in the mouse version of ADRB1.

The cell-based experiments revealed that the mutant form of the beta-1 adrenergic receptor -- the protein encoded by the ADRB1 gene, which plays a role in a variety of essential biological processes -- degrades more rapidly than the non-mutant version, suggesting that it might also function differently.

This hunch was confirmed in mouse experiments. The researchers discovered that the ADRB1 gene was highly expressed in the dorsal pons, a region of the brainstem involved in regulating sleep. Using a technique known as optogenetics, in which cells are modified so they can be activated by light, the researchers focused light on neurons in the pons to stimulate those in which ADRB1 was expressed. Triggering these neurons immediately roused sleeping mice -- specifically, those that were experiencing non-REM sleep, the sleep phase during which these neurons are not normally active -- demonstrating that these neurons promote wakefulness.

Additional experiments showed that wakefulness-promoting neurons in the pons with the mutated version of ADRB1 were more easily activated. Furthermore, the ratio of wakefulness-promoting to sleep-promoting neurons skewed heavily towards the former in mice with the ADRB1 mutation. These experiments suggest that the mutant form of ADRB1 promotes natural short sleep because it helps build brains that are easier to rouse and that stay awake longer.

Though they sleep less, natural short sleepers don't suffer any of the adverse health effects associated with sleep deprivation. "Today, most people are chronically sleep deprived. If you need eight to nine hours, but only sleep seven, you're sleep deprived," Fu said. "This has well-known, long-term health consequences. You're more likely to suffer from cardiovascular disease, cancer, dementia, metabolic problems and a weakened immune system."

But natural short sleepers actually seem to benefit from this quirk of their biology. Fu says researchers have found that short sleepers tend to be more optimistic, more energetic and better multitaskers. They also have a higher pain threshold, don't suffer from jet lag and some researchers believe they may even live longer. Though the exact reasons for these benefits remain unknown, Fu and Ptáček think their work represents an important step towards understanding the connection between good sleep and overall health.

"Natural short sleepers experience better sleep quality and sleep efficiency," Fu said. "By studying them, we hope to learn what makes for a good night's sleep, so that all of us can be better sleepers leading happier, healthier lives."

Traditional lithium-ion (Li-ion) batteries cannot satisfy increasing demand for large-scale electricity consumption. Rechargeable aprotic lithium-oxygen (Li-O2) batteries have become potential candidates due to their ultrahigh theoretical energy density, which is about 10 times that of Li-ion batteries. Lithium metal as anode is one of the key factors in obtaining such high specific capacity.

However, the use of a lithium metal anode inevitably triggers serious safety issues because the dendrite growth of lithium will pierce the separator and give rise to a short-circuit fire. Furthermore, the semi-open nature as well as the oxidizing environment of Li-O2 batteries will cause more severe parasitic side reactions, thus hindering the development of Li-O2 batteries. Therefore, it is vital to figure out how to effectively protect the lithium metal anode of Li-O2 batteries.

Recently, a research team led by ZHANG Xinbo from the Changchun Institute of Applied Chemistry (CIAC) of the Chinese Academy of Sciences developed an electrolyte regulation strategy by in situ coupling of CF3SO3- on hydrophobic silica colloidal particles via electrostatic interactions in order to prevent lithium dendrite growth and corrosion. These findings were published in Matter on August 28.

The researchers found that this strategy could couple the anion with nanosilica via electrostatic interaction thus avoiding the formation of a strong electrical field during the lithium deposition process.

A hydrophobic silica colloid electrolyte (HSCE) with a low diffusion coefficient of 10 wt% along with the hydrophobic property of silica led to a 980-times better anticorrosion effect, thus greatly reducing lithium corrosion in Li-O2 batteries. Moreover, by using 10 wt% HSCE, stable and long-life electrochemical performance was obtained in Li-O2 batteries.

"We believe this comprehensive and effective protection strategy can spark more inspiration in electrolyte regulation methods, thus achieving better electrochemical performance," said ZHANG.

This study also provides an effective electrolyte regulation strategy to solve the dendrite and corrosion issues in alkali-O2 batteries and alkali-air batteries. These batteries have the potential for good electrochemical performance in practical applications, and will help release the great potential of alkali metal anodes.

HANOVER, N.H. - August 28, 2019 - Hot and dry conditions coupled with increasing population will reduce the amount of water available for human, agricultural and ecological uses along the Nile River, according to a study from Dartmouth College.

The study, published in the AGU journal Earth's Future, shows that water scarcity is expected to worsen in coming decades even as climate models suggest more precipitation around the river's source in the Upper Nile Basin.

An increase in the frequency of hot and dry years could impact the water and food supplies for as many as 250 million people in the Upper Nile region alone toward the end of the century.

"Climate extremes impact people," said Ethan Coffel, a fellow at Dartmouth's Neukom Institute for Computational Science and lead author of the study. "This study doesn't only look at high-level changes in temperature or rainfall, it explains how those conditions will change life for real people."

The Upper Nile Basin is a chronically water-stressed region that includes western Ethiopia, South Sudan, and Uganda. Nearly all of the rain that feeds the Nile's northward flow to Egypt and the Mediterranean Sea falls in this area that is already home to 200 million people.

"It's hard to overstate the importance of the Nile, and the risk of increasing water insecurity in an already water-scarce place," said Justin Mankin, an assistant professor of geography at Dartmouth and senior researcher on the study. "The Nile has served as an oasis for water, food, commerce, transportation and energy for thousands of years. But we show that the river won't be able to consistently provide all of those competing services in coming decades."

Using a mix of available climate models, the study demonstrates that it is likely that the Upper Nile Basin will experience an increase in regional precipitation for the remainder of this century. The projected upward trend in precipitation comes as a result of increased atmospheric moisture normally associated with warming.

At the same time, the study finds that hot and dry years in the region have become more frequent over the past four decades. Despite some uncertainties in the models, this trend is projected to continue throughout the century with the frequency of hot and dry years as much as tripling even if warming is limited to only 2 degrees Celsius.

Further complicating conditions, population in the region is projected to nearly double by 2080 and will impose large additional demands on water resources.

As a result, the report finds that increased evaporation from higher temperatures coupled with the doubling of runoff demand from a larger population counteract any projected increase in rainfall. The trend of increased precipitation will simply be too slow to result in significant changes in runoff over the time periods studied.

"At first glance you would expect more rain to reduce scarcity, but not on the Nile. The dice are loaded for additional hot and dry years in the future, meaning increasing shocks to households because of crop yield declines and less water available for households to be resilient against warming temperatures," said Mankin.

According to the study, annual demand for water runoff from the Nile will regularly exceed supply by 2030, causing the percentage of the Upper Nile population expected to suffer from water scarcity to rise sharply. By 2080, the study estimates that as much as 65 percent of the regional population - 250 million people - could face chronic water scarcity during excessively hot and dry years.

Even during normal years, the researchers found that as many as 170 million people on average could encounter unmet demand annually by the latter part of the century. Fewer than 25 million people in the region are projected to suffer from water scarcity in 2020.

Most of the increase in water demand is expected to occur during a period of rapid population rise between 2020 and 2040.

"The Nile Basin is one of several fast growing, predominantly agricultural regions that is really on the brink of severe water scarcity. Climate change coupled with population growth will make it much harder to provide food and water for everyone in these areas. Those environmental stresses could easily contribute to migration and even conflict," said Coffel.

To confirm the connection between the impact on food supply and climate conditions in the region, the researchers assessed agricultural yields data from six major crops in Ethiopia's food supply: maize, millet, barley, pulses, sorghum, and wheat.

While food shortages in the region are complex, and can result from a variety of factors such as governance and conflict, the study demonstrates that nearly all recent regional crop failures have occurred amid hot and dry conditions when water runoff is scarcer.

According to the paper, the frequency of hot and dry years that can cause poor crop yields is projected to increase from 10 percent to 15 percent depending on modelling assumptions on climate and greenhouse gas emissions. The result is less water and less food for a growing population.

"We already have a global-scale picture of water scarcity, but that does not tell the story for people in any particular place. With this study, we are able to explain these changes in water scarcity and what that actually means for the millions of people who are going to be in water poverty. It is no longer just colors of basins on a map."

Researchers from Columbia University and the United States Military Academy contributed to this study.

BOSTON - Everyone knows that achieving or maintaining a healthy body weight is one key to preventing cardiovascular disease. But even experts don't agree on the best way to achieve that goal, with some recommending eliminating carbohydrates and others emphasizing reducing fats to lose weight. Few studies have investigated the effects of these specific macronutrients on cardiovascular health.

In a study published online in the International Journal of Cardiology, researchers at Beth Israel Deaconess Medical Center (BIDMC) examined the effects of three healthy diets emphasizing different macronutrients - carbohydrates, proteins, or unsaturated fats - on a biomarker that directly reflects heart injury. Using highly specific tests, the team found that all three diets reduced heart cell damage and inflammation, consistent with improved heart health.

"It's possible that macronutrients matter less than simply eating healthy foods," said corresponding author Stephen Juraschek, MD, PhD, Assistant Professor of Medicine at BIDMC and Harvard Medical School. "Our findings support flexibility in food selection for people attempting to eat a healthier diet and should make it easier. With the average American eating fewer than two servings of fruit and vegetables a day, the typical American diet is quite different from any of these diets, which all included at least four to six servings of fruits and vegetables a day."

Juraschek and colleagues analyzed stored blood samples from 150 participants of the Optimal MacroNutrient Intake Trial to Prevent Heart Disease (OmniHeart) trial, a two-center, inpatient feeding study conducted in Boston and Baltimore between April 2003 and June 2005. The average age among the study participants was 53.6 years, while 55 percent were African American and 45 percent were women. The participants - all of whom had elevated blood pressure, but were not yet taking medications to control hypertension or cholesterol - were fed each of three diets - emphasizing carbohydrates, protein, or unsaturated fat - for six weeks with feeding periods separated by a washout period.

The diets were: a carbohydrate-rich diet similar to the well-known DASH diet, with sugars, grains and starches accounting for more than half of its calories; a protein-rich diet with 10 percent of calories from carbohydrates replaced by protein; and an unsaturated fat-rich diet with 10 percent of calories from carbohydrates replaced by the healthy fats found in avocados, fish and nuts. All three diets were low in unhealthy saturated fat, cholesterol, and sodium, while providing other nutrients at recommended dietary levels. The research team looked at the effects of each diet on biomarkers measured at the end of each dietary period compared to baseline and compared between diets.

All three healthy diets reduced heart injury and inflammation and acted quickly within a 6-week period. However, changing the macronutrients of the diet did not provide extra benefits. This is important for two reasons: First, the effects of diet on heart injury are rapid and cardiac injury can be reduced soon after adopting a healthy diet. Second, it is not the type of diet that matters for cardiac injury (high or low fat, high or low carb), but rather the overall healthfulness of the diet.

"There are multiple debates about dietary carbs and fat, but the message from our data is clear: eating a balanced diet rich in fruits and vegetables, lean meats, and high in fiber that is restricted in red meats, sugary beverages, and sweets, will not only improve cardiovascular risk factors, but also reduce direct injury to the heart," said Juraschek. "Hopefully, these findings will resonate with adults as they shop in grocery stores and with health practitioners providing counsel in clinics throughout the country."

BELLINGHAM, Washington, USA and CARDIFF, UK - In an article published in the peer-reviewed, open-access SPIE publication Neurophotonics, "A multi-site microLED optrode array for neural interfacing," researchers present an implantable optrode array capable of exciting below-surface neurons in large mammal brains at two levels, both by structured-light delivery and large-volume illumination. This development is promising for studies aiming to link neural activity to specific cognitive functions in large mammals.

While other optogenetic devices have been previously developed, this latest innovation addresses a multitude of ongoing challenges and improvements when it comes to optical stimulation and neuroscience in large animal models. Enhanced elements include depth of access, heat control, and an electric delivery system compatible with future wireless applications. This is achieved by connecting a glass needle array to a custom-built microLED array and creating a compact and lightweight device optimally suited for behavioral studies.

This new technology heralds exciting potential for new mammalian behavioral discoveries, according to Neurophotonics Associate Editor Anna Wang Roe, a professor in the Division of Neuroscience at the Oregon National Primate Research Center and director of the Interdisciplinary Institute of Neuroscience and Technology at Zhejiang University in Hangzhou, China. "The development of a large array multisite optical stimulator is a significant advance in the field of optogenetics and optical stimulation," she said. "Having this array will lead to the ability to stimulate multiple cortical sites simultaneously or sequentially, in a cell-type specific manner. It may also open up the possibility of stimulating with different wavelengths, and therefore different cell types, at selected locations. This capability broadens the menu of possible stimulation paradigms for brain-machine interface."

Patients with gout are at increased risk of chronic kidney disease and kidney failure, according to new University of Limerick (UL), Ireland led research.

In one of the largest and most detailed studies ever conducted, patients recruited in general practice with a diagnosis of gout were more than twice as likely to develop kidney failure than those without, according to the study led by researchers at University of Limerick's (UL) Graduate Entry Medical School (GEMS).

The largest and most detailed study ever published on this subject used data from more than 620,000 patients in the UK health system.

It found that gout patients were also more likely to suffer a short-term deterioration in kidney function, as well as a sustained deterioration of function to less than 10% of normal, compared to patients without gout.

The researchers based their findings on results of a large UK-wide study that analysed data from the Clinical Research Practice Data Datalink (CPRD), a research database that collects clinical information on patients attending primary care centres from across the UK.

In their analysis, researchers analysed the risk of advanced chronic kidney disease (CKD) in 68,897 gout patients followed for an average of 3.7 years and compared them to 554,964 patients without gout.

"The results were quite astonishing," said Professor Austin Stack, Foundation Chair of Medicine at UL GEMS who is lead author of the study and Principal Investigator for the UL Kidney Health Consortium at the Health Research Institute and Consultant Nephrologist at UL Hospitals.

"While we always believed that high levels of uric acid might be bad for kidneys and that patients with gout may have a higher risk of kidney failure, we were quite surprised by the magnitude of the risk imposed by gout in these patients. We were particularly interested in the risk of advanced kidney disease, as these patients in general have a higher risk of kidney failure and death.

"In our analysis, we defined advanced kidney disease based on four specific criteria; need for dialysis or kidney transplant; failing kidney function to less than 10% of normal; doubling of serum creatinine from baseline; and death associated with CKD.

"Overall, we discovered that patients who suffered from gout had a 29% higher risk of advanced CKD compared to those without gout. Indeed when we analysed each of the components of advanced kidney disease, we found that in general gout patients were at higher risk of a deterioration in kidney function compared to those without.

"Astonishingly, when we looked at the risk of kidney failure and those who needed dialysis or a kidney transplant, we found that gouts patients had more than a 200% higher risk of kidney failure than those without gout," Professor Stack added of the study, which has just been published by medical journal BMJ Open.

The study sheds new light on the importance and potential impact of gout on kidney function. Although previous studies have shown that gout patients have a higher burden of kidney disease, none has convincingly shown that gout can contribute to the development of kidney failure.

"Our study had several important strengths that overcame the limitations of previous studies. It is one of the largest studies ever conducted with over 620,000 patients included," said Professor Stack.

"Second, the study was representative of patients that are typically seen in general practice within the UK health system. Third, the analysis accounted for known confounders - factors that may have contributed to the development or kidney disease like hypertension and diabetes - and our findings were further confirmed in several additional analysis. Taken together, the findings from this study suggest that gout is an independent risk factor for progression of CKD and kidney failure."

Gout is the most common inflammatory arthritis which causes severe pain and suffering due to a build-up of uric acid in joints. It affects almost 2.5 % of the adult population and causes significant pain and disability due to its effects on joints, tendons and bone. Treatments that lower uric acid levels in the blood stream are effective in preventing both the acute flares of gout and the long-term damage it causes in joints, however current evidence shows that gout remains poorly managed in the population.

CKD is a common chronic condition that affects around 15% of adults in the Irish health system and has a major impact on a person health.

"Each year over 450 patients develop kidney failure in Ireland and require some form of dialysis treatment or a kidney transplant," explained Professor Stack.

"This continues to be the case despite our best efforts at controlling blood pressure m diabetes and other well established risk factors. In fact in over a decade, the numbers of patients who develop kidney failure in Ireland has increased from 2,848 in 2005 to 4,440 in 2017 (a growth of 56%).

"The result of this new research suggests that gout may also play an important role in the progression of kidney disease. The identification of gout as a potential risk factor opens up new opportunities for the prevention of kidney disease and its consequences," added Professor Stack.

Autism rates among racial minorities in the United States have increased by double digits in recent years, with black rates now exceeding those of whites in most states and Hispanic rates growing faster than any other group, according to new University of Colorado Boulder research.

The study, published this month in the Journal of Autism and Developmental Disorders, also found that prevalence of autism among white youth is ticking up again, after flattening in the mid-2000s.

While some of the increase is due to more awareness and greater detection of the disorder among minority populations, other environmental factors are likely at play, the authors conclude.

"We found that rates among blacks and Hispanics are not only catching up to those of whites -- which have historically been higher -- but surpassing them," said lead author Cynthia Nevison, an atmospheric research scientist with the Institute of Arctic and Alpine Research. "These results suggest that additional factors beyond just catch-up may be involved."

For the study, Nevison teamed up with co-author Walter Zahorodny, an autism researcher and associate professor of pediatrics at Rutgers New Jersey Medical School, to analyze the most recent data available from the Individuals with Disabilities Education Act (IDEA) and the Autism and Developmental Disabilities Monitoring (ADDM) Network.

IDEA tracks prevalence, including information on race, among 3-to-5-year-olds across all 50 states annually. ADDM tracks prevalence among 8-year-olds in 11 states every two years.

The new study found that between birth year 2007 and 2013, autism rates among Hispanics age 3-5 rose 73%, while rates among blacks that age rose 44% and rates among whites rose 25%.

In 30 states, prevalence among blacks was higher than among whites by 2012.

In states with "high prevalence," 1 in 79 whites, 1 in 68 blacks and 1 in 83 Hispanics born in 2013 have been diagnosed with autism by age 3-5.

Other states like Colorado fell in a "low-prevalence" category, but the authors cautioned that differences between states likely reflect differences in how well cases are reported by age 3-5. They also said the real prevalence is substantially higher, as many children are not diagnosed until later in life.

"There is no doubt that autism prevalence has increased significantly over the past 10 to 20 years, and based on what we have seen from this larger, more recent dataset it will continue to increase among all race and ethnicity groups in the coming years," said Zahorodny.

In 2018, the Centers for Disease Control reported that about 1 in 59 children of all races have been diagnosed with autism and that rates had risen 15 percent overall from the previous two year period, largely due to better outreach and diagnosis among historically underdiagnosed minority populations.

"Our data contradict the assertion that these increases are mainly due to better awareness among minority children," said Zahorodny. "If the minority rates are exceeding the white rates that implies some difference in risk factor, either greater exposure to something in the environment or another trigger."

Established risk factors associated with autism include advanced parental age, challenges to the immune system during pregnancy, genetic mutations, premature birth and being a twin or multiple.

The authors said that, based on current research, they cannot pinpoint what other environmental exposures might be factoring into the increases in autism. But they would like to see more research done in the field.

A single cholesterol-derived molecule, called 27-hydroxycholesterol (27HC), lurks inside your bloodstream and will increase your body fat, even if you don't eat a diet filled with red meat and fried food. That kind of diet, however, will increase the levels of 27HC and body weight.

"We found 27HC directly affects white adipose (fat) tissue and increases body fat, even without eating the diet that increases body fat," reports University of Houston assistant professor of biology Michihisa Umetani in the journal Endocrinology. First author of the paper, doctoral student Arvand Asghari, adds, "But it does need some help from the diet to increase body weight because it expands the capacity of the fat already in the body."

Long term applications of the findings could lead researchers to a treatment that reduces the levels of 27HC, which could result in reduced capacity for making fat. "We hope to develop a new therapeutic approach toward modulating 27HC levels to treat cholesterol and/or estrogen receptor-mediated diseases such as cardiovascular diseases, osteoporosis, cancer and metabolic diseases," said Umetani, whose lab is part of the UH Center for Nuclear Receptors and Cell Signaling.

Prior to this research, 27HC was known as an abundant cholesterol metabolite, and Umetani's group has reported its detrimental effects on the cardiovascular system, but its impact on obesity was not well known.

Role of estrogen receptors

Obesity is one of the main risk factors influencing cardiovascular disease worldwide in both men and women and estrogen plays a role in both sexes. Menopause in females, with its accompanying decrease in estrogen, seems to hasten the increase in fat tissue because estrogen protects against adiposity and body weight gain. In men, estrogens are also synthesized locally by conversion of testosterone, so they may also play important roles in the development of fat tissues in males.

"Estrogen receptors (ERα and ERβ) are members of the nuclear receptor superfamily and are present in adipocytes," said Umetani. "Patients with a non-functional ERα are obese, and those that do not have ERα have increased fat tissue even when they eat the same amount of food, indicating that ERα is the important isoform in the regulation of adipose tissue by estrogen."

The main function of 27HC in the liver is to reduce excess cholesterol. Previously, Umetani discovered that 27HC binds to estrogen receptors and acts as an inhibitor of ER action in the vasculature. It turned out that the effects by 27HC are tissue-specific, thus 27HC is the first identified naturally-produced selective estrogen receptor modulator, or SERM.

The oldest stars in our Galaxy are also the busiest, moving more rapidly than their younger counterparts in and out of the disk of the Milky Way, according to new analysis carried out at the University of Birmingham.

The findings provide fresh insights into the history of our Galaxy and increase our understanding of how stars form and evolve.

Researchers calculate that the old stars are moving more quickly in and out of the disc - the pancake-shaped mass at the heart of the Galaxy where most stars are located.

A number of theories could explain this movement - it all depends where the star is in the disc. Stars towards the outskirts could be knocked by gravitational interactions with smaller galaxies passing by. Towards the inner parts of the disc, the stars could be disturbed by massive gas clouds which move along with the stars inside the disc. They could also be thrown out of the disc by the movement of its spiral structure.

Dr Ted Mackereth, a galactic archaeologist at the University of Birmingham, is lead author on the paper. He explains: "The specific way that the stars move tells us which of these processes has been dominant in forming the disc we see today. We think older stars are move active because they have been around the longest, and because they were formed during a period when the Galaxy was a bit more violent, with lots of star formation happening and lots of disturbance from gasses and smaller satellite galaxies. There are lots of different processes at work, and untangling all these helps us to build up a picture of the history of our Galaxy."

The study uses data from the Gaia satellite, currently working to chart the movements of around 1 billion stars in the Milky Way. It also takes information from APOGEE, an experiment run by the Sloan Digital Sky Survey that uses spectroscopy to measure the distribution of elements in stars, as well as images from the recently-retired Kepler space telescope.

Measurements provided by Kepler show how the brightness of stars varies over time, which gives insights into how they vibrate. In turn, that yields information about their interior structure, which enables scientists to calculate their age.

The Birmingham team, working with colleagues at the University of Toronto and teams involved with the Sloan Digital Sky Survey, were able to take these different data strands and calculate the differences in velocity between different sets of stars grouped by age.

They found that the older stars were moving in many different directions with some moving very quickly out from the galactic disk. Younger stars move closely together at much slower speeds out from the disc, although they are faster than the older stars as they rotate around the Galaxy within the disc.

The eventual goal of the research is to link what is known about the Milky Way with information about how other galaxies in the universe formed, ultimately being able to place our Galaxy within the very earliest signatures of the universe.

Large amounts of a certain type of bacteria, most likely from outdoors, may reduce the child's risk of developing asthma. This was shown by Finnish Institute for Health and Welfare's (THL) new study that analysed the microbiota in over 400 Finnish homes.

However, the study was unable to identify individual bacterial taxa that provide protection against asthma.

It remains unclear why exposure to microbes protects against asthma. Earlier studies have found that high diversity of microbes is of particular importance in protecting against asthma.

THL's study, published in June, also showed that farm-like microbiota of the child's home protected children from asthma also in urban homes.

Finns spend 90% of the time indoors - contact with natural microbiota has decreased

On average, Finns spend 90% of the time indoors and more and more often in an urban environment. This means less contact with natural microbiota. The diversity of bacteria protects against asthma but certain soil microbes protect even more effectively.

"In this study, we identified certain groups of bacteria found in soil that protect against asthma. These groups of bacteria provided more effective protection against asthma than the previously observed diversity of microbiota," says Anne Karvonen, Senior Researcher at THL.

"If we want to develop products that protect against asthma, such as microbes that you can bring home or place on the skin, it would have been helpful to identify individual asthma-protective bacteria. However, our results help to restrict the bacteria that should be studied more."

Increased contact with nature is beneficial.

"We could explore nature with children more often and play in the nature instead of urban playgrounds covered with rubber. With regard to microbial exposure, it is important to have contact with nature in our everyday lives," says Karvonen.

Satisfaction is the most popular metric for marketing decisions around the world, according to a new study from the University of Technology Sydney (UTS) Business School.

Satisfaction measures how satisfied a company's customers are with a company and its product or service. It was the most used metric in eight of the 16 countries studied, and was employed in 53% of all marketing-mix decisions analysed.

Researchers analysed more than 4,000 marketing plans from over 1,600 companies in 16 countries, including Australia, US, Russia, India, UK and China, to uncover the answer.

"Despite trillions spent on marketing globally, managers have said consistently over the last couple of decades that one of the most difficult activities is demonstrating the impact of their marketing actions," says UTS Business School lead researcher Dr Ofer Mintz.

"We wanted to know what metrics managers are using globally, what drives metric use, including cultural influences, and how many metrics managers are using. In today's digital technology-intensive and data-rich environment, it is important for managers to know which metrics count."

The other two most popular metrics to help determine marketing strategy were Awareness and Return on Investment (ROI).

Awareness measures how many people recognise a company, brand, product or service, and was used in 45% of plans.

This was followed by ROI, which measures revenue generated per dollar spent on marketing and was used in 43% of plans.

Other popular metrics included Target Volume, Likeability, and Net Profit.

The study, just published in the Journal of International Business Studies, also found a significant and positive relationship between a company's total metric use and its marketing performance, in each of the 16 countries.

"We found the greater a manager's overall use of quantitative information or metrics when making decisions, the better the performance, accuracy, and overall quality of decisions. It also leads to greater CEO satisfaction, and increased profits and shareholder value," says Dr Mintz.

"Metrics provide information to help managers diagnose, coordinate, and monitor their actions. They also quantify trends or outcomes, reveal current relationships, and help predict the results of future actions," he says.

The study identified 84 different marketing and financial metrics in use, with managers employing on average around nine metrics per marketing-mix.

Country and organisational culture also had an impact on the types of analytics managers used.

South Korea, China and India had the highest use of metrics, and Japan, France and the US had the lowest use. Managers residing in countries with a lower tolerance for uncertainty and ambiguity employed significantly more metrics for their marketing decisions.

Other areas of national cultural difference that had an impact on metric use included collectivism, assertiveness, power distance, and future orientation. The study also identified organisational characteristics that drove metric use, however the result was counterintuitive.

"Rigid organisational cultures were less effective than more organic, free-flowing cultures where there was flexibility for managers to exchange ideas and choose their own metrics, rather than focusing on a strict set of instructions," says Dr Mintz.

"It's important for managers to understand the different drivers for metric use, both cultural and organisational. It is also useful to know what metrics other managers are using, and how many they are using, as it provides a benchmark for their own marketing-mix."

On many evenings during spring and fall migration, tens of millions of birds take flight at sunset and pass over our heads, unseen in the night sky. Though these flights have been recorded for decades by the National Weather Services' network of constantly scanning weather radars, until recently these data have been mostly out of reach for bird researchers.

That's because the sheer magnitude of information and lack of tools to analyze it made only limited studies possible, says artificial intelligence (AI) researcher Dan Sheldon at the University of Massachusetts Amherst.

Ornithologists and ecologists with the time and expertise to analyze individual radar images could clearly see patterns that allowed them to discriminate precipitation from birds and study migration, he adds. But the massive amount of information ¬- over 200 million images and hundreds of terabytes of data - significantly limited their ability to sample enough nights, over enough years and in enough locations to be useful in characterizing, let alone tracking, seasonal, continent-wide migrations, he explains.

Clearly, a machine learning system was needed, Sheldon notes, "to remove the rain and keep the birds."

Now, with colleagues from the Cornell Lab of Ornithology and others, senior authors Sheldon and Subhransu Maji and lead author Tsung-Yu Lin at UMass's College of Information and Computer Sciences unveil their new tool "MistNet." In Sheldon's words, it's the "latest and greatest in machine learning" to extract bird data from the radar record and to take advantage of the treasure trove of bird migration information in the decades-long radar data archives. The tool's name refers to the fine, almost invisible, "mist nets" that ornithologists use to capture migratory songbirds.

MistNet can "automate the processing of a massive data set that has measured bird migration over the continental U.S. for over two decades," Sheldon says. "This is a really important advance. Our results are excellent compared with humans working by hand. It allows us to go from limited 20th-century insights to 21st-century knowledge and conservation action." He and co-authors point out, "Deep learning has revolutionized the ability of computers to mimic humans in solving similar recognition tasks for images, video and audio."

For this work, supported in part by a National Science Foundation grant to Sheldon to design and test new mathematical approaches and algorithms for such applications, the team conducted a large-scale validation of MistNet and competing approaches using two evaluation data sets. Their new paper also presents several case studies to illustrate MistNet's strengths and flexibility. Details appear in the current issue of Methods in Ecology and Evolution.

MistNet is based on neural networks for images and includes several architecture components tailored to the unique characteristics of radar data, the authors point out. Radar ornithology is advancing rapidly and leading to significant discoveries about continent-scale patterns of bird movements, they add.

The team made maps of where and when migration occurred over the past 24 years and animated these to illustrate, for example, "the most intensive migration areas in the continental United States," Sheldon explains - a corridor roughly along and just west of the Mississippi River. MistNet also allows researchers to estimate flying velocity and traffic rates of migrating birds.

MistNet, designed to address one of the "long-standing challenges in radar aero-ecology," the authors note, comes just in time to help scientists better use not only existing weather radar data, but the "explosion" of large new data sets generated by citizen science projects such as eBird, animal tracking devices and earth observation instruments, say Sheldon and colleagues.

"We hope MistNet will enable a range of science and conservation applications. For example, we see in many places that a large amount of migration is concentrated on a few nights of the season," Sheldon says. "Knowing this, maybe we could aid birds by turning off skyscraper lights on those nights." Another question the ornithologists are interested in is the historical timing, or phenology, of bird migration and whether it, and timely access to food, have shifted with climate change.

Soil scientists can't possibly be everywhere at once to study every bit of soil across the planet. Plus, soils are constantly changing.

Conditions like weather and land use have a major impact on soil over time. So, to understand everything about soil, we would need to be continuously studying soil around the world. Since this isn't possible, soil scientists are turning to math to predict what happens at the soil's surface.

Soil models - just like economic models - are helpful to predict trends and make suggestions. An example might be the impact of climate change on water processes in the soil. Models help fill in the gaps of measured data.

Since soil is a complex environment, a soil model consists of many pieces that represent different processes. One important aspect of soil models - how water interacts with soil at the land surface - was recently discussed by a group of almost 30 scientists. Their work was recently published in Vadose Zone Journal.

Water infiltration at the land surface is a crucial area of study. Infiltration refers to what fraction of the water is getting absorbed by the soil. Being able to predict if precipitation will run over the soil surface or soak in is crucial in land management decisions. It affects aspects of land management like erosion control. It is also important in making sure we have a safe and clean water supply. Land surface models can help scientists predict and simulate the water and energy cycles from the soil's surface into the atmosphere.

Each piece of a land surface model is important. The study team found that information about infiltration warrants more attention in land surface models.

In order to be truly useful, land surface models need to include loads of information. This includes soil structure, soil moisture and temperature, precipitation, terrain, plants, and more. Scientists use the information to calculate the Earth's climate or see how land use changes may affect it.

Harry Vereecken, Forschungszentrum Jülich in Germany, was the lead author of this effort. "The review found important gaps in the current treatment of infiltration processes in land surface models," says Vereecken. "Current models don't account for the effect of structural properties on soil water dynamics. Also, we saw the lack of a consistent framework to upscale infiltration processes from different scales and the large diversity in approaches to describing them."

The group is calling on scientists to work together and lend their skills to better include this information in land surface models. This is so the models better reflect the reality of what's happening at the Earth's surface.

Their review was a way to compile scientific research from over a long period of time and give suggestions about where soil scientists should focus their efforts next. In looking over lots of research, they found there's no consistent way to predict infiltration. They also found that some aspects of soil that affect infiltration are often ignored.

"The climate and Earth sciences community typically operate at a larger scale than the soil science community," Vereecken explains. "Soil scientists have mostly worked at smaller scales, such as plot to field scale to study processes and often did not include atmospheric processes in their studies. We wanted to write about the importance of these communities coming together. This is the first review ever that addressed the handling of infiltration processes in these models."

He adds that they hope their work provides a common understanding about how infiltration processes are dealt with in land surface models. While it can be difficult to quantify these complex processes and combine them into larger models, it's important in studying the state of the planet. Both groups need each other. Without soil scientists working on a smaller scale, others won't have data for their models.

"Because soil exerts a key control on climate-related processes, it can add relevance to the research we are doing as soil scientists," Vereecken says. "We hope this can serve as a kind of reference paper for other scientists and connect those that work on different aspects of land surface models."

When the daily stress of parenting becomes chronic it can turn into parental burnout, an intense exhaustion that leads parents to feel detached from their children and unsure of their parenting abilities, according to research published in Clinical Psychological Science, a journal of the Association for Psychological Science. This type of burnout can have serious consequences for both parent and child, increasing parental neglect, harm, and thoughts about escape.

"In the current cultural context, there is a lot of pressure on parents," says lead researcher Moïra Mikolajczak of UCLouvain. "But being a perfect parent is impossible and attempting to be one can lead to exhaustion. Our research suggests that whatever allows parents to recharge their batteries, to avoid exhaustion, is good for children."

Mikolajczak and coauthors James J. Gross of Stanford University and Isabelle Roskam of UCLouvain became interested in the issue through their clinical encounters with good parents who, as a result of their exhaustion, had become the opposite of what they were trying to be. Although previous research had explored the causes of parental burnout, relatively little was known about its consequences. The researchers decided to directly examine the outcomes associated with parental burnout in two studies that followed parents over time.

In the first study, Mikolajczak and colleagues recruited parents through social networks, schools, pediatricians, and other sources to participate in research on "parental well-being and exhaustion." The parents, mostly French-speaking adults in Belgium, completed three batches of online surveys spaced about 5.5 months apart.

The surveys included a 22-item measure of parental burnout that gauged parents' emotional exhaustion, emotional distancing, and feelings of inefficacy; a six-item measure that gauged their thoughts about escaping their family; a 17-item measure that gauged the degree to which they neglected their childrens' physical, educational and emotional needs; and a 15-item measure that gauged their tendency to engage in verbal, physical, or psychological violence.

Because many of the questions asked about sensitive topics, the researchers also measured participants' tendency to choose the most socially desirable responses when confronted with probing questions.

A total of 2,068 parents participated in the first survey, with 557 still participating at the third survey.

Participants' data revealed a strong association between burnout and the three variables -- escape ideation, parental neglect, and parental violence -- at each of the three time points.

Parental burnout at the first and second survey was associated with later parental neglect, parental violence, and escape ideation. The researchers found that parental burnout and parental neglect had a circular relationship: Parental burnout led to increased parental neglect, which led to increased burnout, and so on. Parental violence appeared to be a clear consequence of burnout.

Importantly, all of these patterns held even when the researchers took participants' tendency toward socially desirable responding into account.

A second online study with mostly English-speaking parents in the UK produced similar findings.

Together, the data suggest that parental burnout is likely the cause of escape ideation, parental neglect, and parental violence.

"We were a bit surprised by the irony of the results," says Mikolajczak. "If you want to do the right thing too much, you can end up doing the wrong thing. Too much pressure on parents can lead them to exhaustion which can have damaging consequences for the parent and for the children."

Additional studies are needed to confirm and extend these findings with broader samples and measures. Nonetheless, the robust pattern of results suggests that there are important lessons to be learned from these findings, the researchers say.

"Parents need to know that self-care is good for the child and that when they feel severely exhausted, they should seek help. Health and child services professionals need to be informed about parental burnout so that they can accurately diagnose it and provide parents with the most appropriate care. And those engaged in policy and public health need to help raise awareness and lift the taboo on parental burnout, which will encourage parents to seek the help they need," Mikolajczak concludes.

PULLMAN, Wash. - For start-up companies looking to launch a new product, hiring star inventors who are accomplished and have a strong record of performance seems like a no brainer.

After all, having more expertise on an innovation team should lead to more product innovation, right?

Unfortunately, product innovation efforts often stall when star inventors and company founders work within the same teams, according to new research from Washington State University, University of Washington and Texas A&M University.

"When you have high-powered innovation teams, members need to be able to work together and be able to defer to each other," said Amrita Lahiri, lead author and assistant professor of management, information systems, and entrepreneurship at Washington State University's Carson College of Business.

"Conflicts may arise when you have team members who both think they are the experts," she said.

Researchers examined the relationship between founders and star employees in product innovation teams, how well they collaborate, and what impact those relationships have on the organization's ability to launch new products.

"We found that the presence of both the star employee and the founder within a company has a positive effect on the firm's performance, but when you have both of them together on a team, the outcomes can become diminished," said Lahiri.

According to Lahiri, start-up companies should consider the following when hiring extremely accomplished inventors or "star" employees for product innovation teams, especially when the founder is also on the team:

Establish a clear chain of command within the team

Hire star employees who have prior experience working in new ventures 

If you are a founder-inventor, be adaptable to change

Establish a clear chain of command

According to Lahiri, founders' influence in an organization comes from their position in the firm's hierarchy, whereas "star" employees' influence typically comes from their record of past work and accomplishments.

Conflict can arise when the roles within a team are not clearly defined, as the influence of power comes from different positions and previous experiences. This may lead to disagreements about the team's direction and how to best meet their objectives--thus stalling the innovation process.

Hire star employees who have previous start-up experience

The type of organization where a star employee has previously worked can also affect how well founders and star employees collaborate.

"Someone who has been previously employed by another small organization is typically much better off in a start-up setting," Lahiri said.

Inventors who have worked for other start-ups have experience working in more informal, collaborative settings, simply because of how start-ups operate.

In fact, researchers observed start-ups that hired star employees with previous start-up experience launched more products compared to startups that brought in star employees from larger organizations.

If you are a founder, be adaptable to change

Finally, no matter who is on the product innovation team, founders must remain adaptable to change.

"I find in my broader research that a founder's role and the expectations of investors change as the venture evolves," Lahiri said.

In the early stages of the start-up, a founder may need to be more hands-on in product development, she said. However, as the organization evolves, the founder needs to shift more attention toward managerial aspects.

"It is important for founders to be aware that their roles will change over time and willing to delegate," Lahiri said.