Body

GRAND RAPIDS, Mich. (Oct. 27, 2015)-- Recent laboratory findings provide novel insight into potential new therapeutic approaches for triple-negative breast cancer, a particularly difficult to treat and aggressive form of the disease.

In a recent study published online in the journal Clinical Cancer Research, scientists from Van Andel Research Institute (VARI) and Wayne State University demonstrated in preclinical experiments that the drug cabozantinib inhibits growth of several triple-negative breast cancer subtypes.

Washington, D.C.--October 27, 2015--Australian researchers have found a way to boost the effectiveness and cross-protective capabilities of an influenza A vaccine by adding a simple component. Published this week in mBio, an online open-access journal of the American Society for Microbiology, the research in mice could lead to better seasonal flu vaccines for humans, and also vaccines that could provide community protection in the early stages of an outbreak of a novel flu virus strain.

Seals are not threatening commercial fishing stocks in Irish waters, with the possible exception of wild Atlantic salmon, according to new research led by Queen's University Belfast, Northern Ireland, UK.

The findings show that seals are having no significant impact on populations of the most popular species of fish caught for commercial purposes along the south and west coasts of Ireland, from counties Galway to Waterford.

Bioengineers from Queen Mary University of London (QMUL) have shown for the first time that lithium chloride, a common drug used to treat mental health disorders, could offer an effective treatment against osteoarthritis by disrupting the length of the cells' antennae called primary cilia.

Publishing in the journal FASEB, the scientists show that medical manipulation of the primary cilia, which are tiny hair-like structures protruding from the surface of most human cells, disrupts a key biological process called 'Hedgehog Signalling'.

Diabetic patients are at considerably increased risk for developing surgical site infections (SSIs) while undergoing most types of surgeries, compared to non-diabetic patients, according to a new study published online today in Infection Control & Hospital Epidemiology, the journal of the Society for Healthcare Epidemiology of America (SHEA).

Environment can make all the difference in behavior - even at the cellular level. Scientists at the Virginia Tech Carilion Research Institute have discovered even a small shift in environmental factors can change how a cell in the immune system matures.

They published their results Wednesday (Oct. 26, 2015) in Nature's open access journal, Scientific Reports.

EAST LANSING, Mich. --- Women are more likely than men to have a bachelor's degree and a white-collar job, yet continue to earn less than their male counterparts, finds a new study spanning two generations in the United States.

Stephanie Nawyn, a Michigan State University sociologist and study co-author, said the findings reinforce the existence of a "gender revolution" -- except when it comes to salaries.

Baker's yeast cells living together in communities help feed each other, but leave incomers from the same species to die from starvation, according to new research from the University of Cambridge.

The findings, published today in the open access journal eLife, could lead to new biotechnological production systems based on metabolic cooperation. They could also be used to inhibit cell growth by blocking the exchange of metabolites between cells. This could be a new strategy to combat fungal pathogens or tumour cells.

University of Adelaide researchers have uncovered the role played by a family of genes, which can suppress hepatitis C virus (HCV) infection within the liver.

The findings, published in the Journal of Biological Chemistry, shed light on the activity of these genes and how they produce a natural immune response to the virus.

The Guam coconut rhinoceros beetle research team has documented some disturbing and unusual behavior of Oryctes rhinoceros (coconut rhinoceros beetle CRB), which has been published in the September issue of the Florida Entomologist journal.

PORTLAND, Ore., October 27, 2015--A pharmacy-led glycemic control program is linked to improved outcomes for surgical patients with diabetes and those who develop stress-induced hyperglycemia or high blood sugars as a result of surgery, according to a new Kaiser Permanente study published in the American Journal of Pharmacy Benefits.

The study compared patients who had surgery after the glycemic control program started to patients who had surgery before the program started.

ORLANDO, Fla. Oct. 27, 2015 -- An intestinal patch device containing insulin that can be swallowed in the form of a capsule, in development by researchers at University of California Santa Barbara, has demonstrated efficacy of blood glucose management in diabetic rats. This work is being presented Oct. 27 at the 2015 American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition, the world's largest pharmaceutical sciences meeting, in Orlando, Fla. Oct. 25-29.

Farmers who need to control the destructive European corn borer (Ostrinia nubilalis) may soon be able to distinguish it from look-alike species by simply scanning an image of its wing into a computer and pecking a few keys. A technique developed by Polish scientists marks the first time that measurements of key structural features in the wing have been used to identify the borer, potentially a major advance in controlling the pest.

(Barcelona, October 27, 2015) Cancers of the gastrointestinal (GI) tract continue to exert their toll across Europe, with many diagnosed too late for effective treatment. Bowel cancer screening programmes are now underway in most European countries, but screening for other GI cancers is patchy and not necessarily well-targeted. Today, experts at United European Gastroenterology (UEG) call for better risk profiling for all GI cancers in order to develop more targeted approaches to their screening and prevention.

A new study of more than 25,000 men has uncovered four new genetic variants associated with increased risk of testicular cancer.

Testing for these variants combined with all 21 previously identified using genetic sequencing identified men with a 10-fold higher risk of testicular cancer than the population average.

The research, led by scientists at The Institute of Cancer Research, London, is the largest study to date of the genetics of testicular germ cell tumours - the most common cancer in young men.