Body

A 'gap in the armor' of DNA may allow enzyme to trigger cancer-causing mutations

BLOOMINGTON, Ind. -- Research at Indiana University has identified a genetic mechanism that is likely to drive mutations that can lead to cancer.

The study, published today in the Proceedings of the National Academy of Sciences, finds the enzyme APOBEC3G -- a known trigger for mutations that occur as benign tumor cells transform into cancerous malignancies that spread throughout the body -- appears to cause these harmful changes by mutating genes during the replication of DNA.

Evidence-based health care: The care you want, but might not be getting

COLUMBUS, Ohio - As hospital leaders continue to feel pressure to improve patient outcomes and reduce costs, a new study reveals one reason why many organizations fall short.

Use of evidence-based practice among chief nurses and their hospitals is relatively low, according to a survey led by Bernadette Melnyk, dean of the College of Nursing at The Ohio State University.

And many of the hospitals in the study reported poor scores on key performance measures, such as falls and pressure ulcers.

When loved ones battle cancer, families head to Web for information more than support

Athens, Ga. - Loved ones of cancer patients are likely to search for further information about the disease online but less inclined to seek emotional support from social media forums, according to a University of Georgia study published recently in the journal Computers, Informatics, Nursing.

New research sharpens understanding of poison-arrow hunting in Africa

LAWRENCE -- While academic awareness of African peoples' hunting with poison-tipped arrows extends back for centuries, knowledge of the ingenious practice has been scattered among chemistry, entomology and anthropology texts.

Now, a comprehensive study of the hunting tradition of the San peoples of Namibia sheds new light on their use of beetle and plant poisons to boost the lethality of their arrows. The research appears currently in the peer-reviewed journal ZooKeys.

Researchers identify potential targeted therapy for lung cancer using fly model

A drug approved by the Food and Drug Administration (FDA) for melanoma in combination with a common cholesterol-lowering drug may show promise in controlling cancer growth in patients with non-small cell lung cancer (NSCLC), according to new research from the Icahn School of Medicine at Mount Sinai. Study findings will appear in the February 16 print issue of the journal Cell Reports.

Topography shapes mountain biodiversity

A warming climate is likely to drive species to higher, cooler altitudes. A new study highlights a less obvious, yet crucial way in which their new habitat could differ from the one they leave behind.

Semantically speaking: Does meaning structure unite languages?

We create words to label people, places, actions, thoughts, and more so we can express ourselves meaningfully to others. Do humans' shared cognitive abilities and dependence on languages naturally provide a universal means of organizing certain concepts? Or do environment and culture influence each language uniquely?

Using a new methodology that measures how closely words' meanings are related within and between languages, an international team of researchers has revealed that for many universal concepts, the world's languages feature a common structure of semantic relatedness.

Drug that could aid in vaccines activates innate immune system in novel way: UTSW study

DALLAS - Feb. 1, 2016 - A new drug with the potential to aid in vaccine development has been identified by researchers at UT Southwestern Medical Center.

"The drug we made appears safe, and boosts immunity in mice. Therefore, the drug, which is straightforward to synthesize and to couple to antigens that induce an immune response, may prove useful in the generation of vaccines," said Dr. Bruce Beutler, Director of UT Southwestern's Center for the Genetics of Host Defense.

Effectiveness of influenza vaccine for pregnant women may differ by trimester

ATLANTA (Feb. 1, 2016)--In a study to be presented on Feb. 5 in an oral concurrent session at 1:15 p.m. EST, at the Society for Maternal-Fetal Medicine's annual meeting, The Pregnancy Meeting™, in Atlanta, researchers will present findings from a study titled, T-follicular helper (Thf) cell expansion varies by trimester after influenza vaccination in pregnancy.

Study develops new equation for estimating gestational age

ATLANTA (Feb. 1, 2016)--In a study to be presented on Feb. 6 at 8:45 a.m. EST, at the Society for Maternal-Fetal Medicine's annual meeting, The Pregnancy Meeting™, in Atlanta, researchers will present findings from a study titled, The NICHD Fetal Growth Studies: Development of a contemporary formula for estimating gestational age from ultrasound fetal biometrics.

New research uses nanotechnology to prevent preterm birth

ATLANTA, FEB. 4, 2016 ¬¬- Using nanoparticles to engineer a special drug, a team of researchers has demonstrated in mice a new way to both reduce preterm birth and avoid the risks of medication in pregnancy to unborn babies.

New in the Hastings Center Report: Next steps for epigenetics, big data and informed consent, whatever happened to human 'experi

Phone counseling found insufficient to help teen smokers stay quit into young adulthood

SEATTLE - In a 14-year study involving more than 2,000 teen smokers in 50 Washington state high schools, a team of cancer prevention researchers at Fred Hutchinson Cancer Research Center has found that one year of telephone counseling using motivational interviewing and skills training delivered during the senior year of high school is insufficient to help the smokers quit and stay quit up to six years into young adulthood.

Does treatment of subclinical hypothyroidism in pregnant women impact IQ in offspring?

ATLANTA (Feb. 1, 2016)--On Feb. 4 at 8 a.m. EST, in the oral plenary session at the Society for Maternal-Fetal Medicine's annual meeting, The Pregnancy Meeting, in Atlanta, Brian Casey, M.D. with the Eunice Kennedy Shriver National Institute of Child Health and Human Development and Maternal-Fetal Medicine Unit will present findings from a 5-year follow-up study that looked at the treatment of pregnant women with subclinical thyroid dysfunction and whether, or not, that impacted the IQ of their children. The abstract received the Norman Grant award.

Study found adding azithromycin to standard antibiotic reduced infections in C-sections

ATLANTA (Feb. 1, 2016)--In a study to be presented on Feb. 4 in an oral concurrent session at 8 a.m.