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Discovery of a fundamental limit to the evolution of the genetic code

Nature is constantly evolving--its limits determined only by variations that threaten the viability of species. Research into the origin and expansion of the genetic code* are fundamental to explain the evolution of life.

Advance could help grow stem cells more safely

The most productive way scientists have devised to nurture colonies of human embryonic stem cells is to do so atop a bed of mouse cells. That may be fine for lab research, but it poses an unacceptable contamination risk for stem cells intended for transplant into human patients. In a new study, Brown University bioengineers have developed a synthetic bed that works about as well as the mouse cells, called fibroblasts, without any possibility of contamination.

Sex exchange a heightened risk factor among women with incarceration history

PROVIDENCE, R.I. [Brown University] -- Even behind bars it can be a hard question to raise, but new research suggests that asking female inmates whether they have a history of exchanging sex for money or drugs can help identify whether they are at heightened risk for serious health consequences.

River food webs threatened by widespread hydropower practice

The decline of aquatic insects downstream from some hydroelectric dams has been linked to a widespread practice known as hydropeaking, whereby river flows are increased during the day when electricity demands are large, according to a new study led by the U.S. Geological Survey, along with researchers from Oregon State University, Utah State University and Idaho State University.

Englerin analogues with anti-cancer activity

The research group of Prof. Antonio M. Echavarren at ICIQ has designed and synthetized a series of analogues of (-)-Englerin A that are highly selective and effective in the growth-inhibition of renal cancer cells.

No males needed: All-female salamanders regrow tails 36 percent faster

COLUMBUS, Ohio -- The lady salamander that shuns male companionship may reap important benefits.

For instance, when a predator snaps off her tail.

New research from The Ohio State University compared an all-female population of mole salamanders to a related heterosexual species and found they grew their tails back 36 percent faster. The unisexual salamanders (part of the Ambystoma genus) contain DNA of up to five species and reproduce primarily by cloning themselves.

A skeletal marker of physiological stress might indicate good, rather than poor, health

Biological anthropologist Sharon DeWitte studies ancient skeletons that can open a window onto the human history she hopes to illuminate. But as she and graduate student Samantha Yaussy show in a recently published study, some of the markers on the skeletons that scientists use to decipher the past might need to be looked at in a new light.

Less body fat for toddlers taking vitamin D

A healthy intake of vitamin D in the first year of life appears to set children up to have more muscle mass and less body fat as toddlers, according to a new study published in the journal Pediatric Obesity.

The findings emerged from research initially aimed at confirming the importance of vitamin D for bone density. The additional benefit in terms of body composition came as a surprise for the research team.

Children with ADHD may benefit from following healthy behaviors, new study suggests

A new study shows that children with Attention Deficit and Hyperactivity Disorder follow fewer healthy lifestyle behaviors than non-ADHD youth, suggesting that they may benefit from improving lifestyle choices such as increasing water consumption, decreasing screen time and getting at least one hour of physical activity per day.

Two known chemotherapy agents effectively target breast cancer stem cells

AUGUSTA, Ga. - Two existing chemotherapy drugs appear to be a powerful pair in targeting errant stem cells that are making breast cancer and enabling its spread and recurrence, scientists report.

A combination of the drugs, 5-azacytidine and the HDAC inhibitor butyrate, reduces the number of cancer stem cells and improves survival in an animal model of breast cancer, they report in the journal Cancer Research. Alone, neither was effective.

Quieting cells' low-oxygen alarm stops flare-ups in rare bone disorder

PHILADELPHIA - The cellular response to the lack of oxygen fans the flames of flare-ups in a rare bone disorder. In fibrodysplasia ossificans progressiva (FOP), a mutation triggers bone growth in muscles, which limits motion, breathing, and swallowing, among a host of progressive symptoms.

Scientists from the Center for Research in FOP and Related Disorders at the Perelman School of Medicine at the University of Pennsylvania and colleagues examined the critical role of tissue hypoxia, or oxygen starvation, in the induction and amplification of FOP lesions, also called flare-ups.

Endangered venomous mammal predates dinosaurs' extinction, study confirms

The University of Illinois and University of Puerto Rico have completely sequenced the mitochondrial genome for the Hispaniolan solenodon, filling in the last major branch of placental mammals on the tree of life.

The study, published in Mitochondrial DNA, confirmed that the venomous mammal diverged from all other living mammals 78 million years ago, long before an asteroid wiped out the dinosaurs.

Hydropeaking extirpates river insects

Hydropower produces 19% of the world's electricity--far more than all other renewable sources combined. In the face of mounting climate-change effects, the rush to this profuse energy source is expected to continue. However, hydroelectric dams can also produce a number of environmental consequences, many of which are unrecognized or understudied. Writing in an article for BioScience, an interdisciplinary team led by Theodore A.

Maryland climate and health report identifies state's vulnerabilities to climate change

As world leaders convene in Washington, DC this week for the Climate Action 2016 summit, a new report by Maryland public health leaders, the Maryland Climate and Health Profile report, details the impacts of climate change on the health of Marylanders now and in the future.

Hydropeaking of river water levels is disrupting insect survival, river ecosystems

CORVALLIS, Ore. - A group of researchers concluded today in a study in the journal BioScience that "hydropeaking" of water flows on many rivers in the West has a devastating impact on aquatic insect abundance.

The research was based in part on a huge citizen science project with more than 2,500 samples taken on the Colorado River in the Grand Canyon, and collaboration of researchers from the U.S. Geological Survey, Oregon State University, Utah State University and Idaho State University.