Body

An update on natural products with carbonic anhydrase inhibitory activity

Carbon (C) is essential in biology as it forms up to four bonds per atom in an endless variety of complex organic molecules, which are the basis of living cells and viruses (DNA, RNA, proteins, etc.). In biology the carbon cycle is mainly regulated by the hydration of CO2.

Pneumococcal vaccine watches bacteria, strikes only when needed

BUFFALO, N.Y. - A new vaccine allows pneumonia-causing bacteria to colonize inside the body, springing into action only if the bacteria pose a threat.

The breakthrough approach, coupled with the protein-based vaccine's potential to counteract more than 90 strains of the bacteria, has the makings to override how vaccines have worked (destroying bacteria before colonization) since the days of Louis Pasteur.

Fat tissue shows a robust circadian rhythm in a dish

Fat tissue shows a robust circadian rhythm in a dish.

In humans, glucose tolerance varies with time of day, but the mechanism responsible for the variation in insulin sensitivity throughout the day is unclear. In a recent study in The Journal of the Federation of American Societies for Experimental Biology, researchers from Brigham and Women's Hospital and the University of Murcia investigated whether human adipose (fat) tissue possesses its own circadian rhythm in insulin sensitivity that could contribute to this phenomenon.

The social media profile of the Black Lives Matter movement

Researchers at the Georgia Institute of Technology looked at nearly 29 million tweets surrounding four recent Black Lives Matter (BLM) events to identify the social media patterns of its activists. They found that the community is unlike many other social movements because of its ability to bond over the course of many months. More than a third of those who participated via social media for the first time continued their participation during the next BLM event.

Rainfall following drought linked to historic nitrate levels in Midwest streams in 2013

Drought periods followed by rainfall caused nitrate levels to increase to the highest ever measured in some Midwest streams during a 2013 study, according to a U.S. Geological Survey report published today in the Journal of Environmental Quality.

Coral killers

Sometimes good fish go bad. But it's not their fault.

In a three-year effort to understand the effects of known stressors such as overfishing and nutrient pollution on coral reefs, scientists made a totally unexpected finding: A normally healthy interaction between fish and coral had turned deadly.

Climate change likely to turn up heat on koalas

A changing climate means that by 2070 koalas may no longer call large parts of inland Australia home, researchers have found.

Using a detailed ecological model, the University of Melbourne study shows hotter temperatures and altered rainfall patterns will make it much more difficult for koalas to get the water they need -- making inland populations vulnerable to heat-stress.

Sea snakes have extra sense for water living

The move from life on land to life in the sea has led to the evolution of a new sense for sea snakes, a University of Adelaide-led study suggests.

The international team, led by researchers in the University's School of Biological Sciences, studied tiny and poorly understood structures on the heads of snakes called 'scale sensilla'. The research has been published in the Royal Society journal Open Biology.

Adults at risk for diabetes double activity levels through healthy lifestyle program

PITTSBURGH, June 8, 2016 - Adults at risk for type 2 diabetes or heart disease or both can substantially increase their physical activity levels through participating in a lifestyle intervention program developed at the University of Pittsburgh Graduate School of Public Health for use in community-settings, such as senior centers or worksites.

Changing weather patterns threaten grassland sparrows

Two of North America's declining grassland songbirds may be particularly vulnerable to altered weather patterns caused by climate change, according to new research in The Condor: Ornithological Applications.

Mathematical simulation of open-heart surgery lends clues to kidney failure

KNOXVILLE--No one can deny that open-heart surgery, where the heart is exposed and the blood is made to bypass it, is one of the most invasive of all medical procedures. Nearly a third of all patients undergoing heart surgery experience kidney failure, yet little is known about why kidney injury occurs or how to prevent it.

Antibodies triggered by avian influenza virus vaccine illuminate a new path toward a universal flu vaccine

NEW YORK, June 8, 2016 - Diverse antibodies induced in humans by vaccination with an avian influenza virus vaccine may offer broader, more durable protection against multiple strains of influenza than today's vaccines typically provide, according to a study led by Florian Krammer, PhD, Assistant Professor in the Department of Microbiology at the Icahn School of Medicine at Mount Sinai, and Patrick Wilson, PhD, Associate Professor in the Department of Medicine at the University of Chicago.

Clinical trial examines treatment of complicated grief

A new study reports on the results of a randomized clinical trial that looked at whether the antidepressant citalopram would enhance complicated grief treatment psychotherapy, and if citalopram would be efficacious without it in an article published online by JAMA Psychiatry.

Increase in biomarker linked with increased risk of heart disease, heart failure, death

In a study published online by JAMA Cardiology, Elizabeth Selvin, Ph.D., M.P.H., of the Johns Hopkins Bloomberg School of Public Health, Baltimore, and colleagues examined the association of 6-year change in high-sensitivity cardiac troponin T with incident coronary heart disease, heart failure and all-cause mortality.

New study lays groundwork for potential new anti-cancer therapy

Philadelphia, PA, June 8, 2016 - Identifying the cell of origin is crucial to understanding how a tumor develops and metastasizes and for developing targeted therapies. Researchers have found evidence supporting a lymphatic endothelium origin for angiomyolipoma (AML) and lymphangioleiomyomatosis (LAM), two related tumors with previously unknown cellular origins. Furthermore, the newly identified lymphatic endothelial lineage shows translational potential for pharmaceutical treatment. Their findings are published in The American Journal of Pathology.