Promising esophageal reconstruction based on engineered constructs

IMAGE: Tissue Engineering is an authoritative peer-reviewed journal published monthly online and in print in three parts: Part A, the flagship journal published 24 times per year; Part B: Reviews, published...

Image credit: 
(c) 2019 Mary Ann Liebert, Inc., publishers

New Rochelle, NY, June 14, 2019-The loss of complete segments of the esophagus often results from treatments for esophageal cancer or congenital abnormalities, and current methods to re-establish continuity are inadequate. Now, working with a rat model, researchers have developed a promising reconstruction method based on the use of 3D-printed esophageal grafts. Their work is published in Tissue Engineering, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. Click here to read the article for free through July 14, 2019.

Eun-Jae Chung, MD, PhD, Seoul National University Hospital, Korea, Jung-Woog Shin, PhD, Inje University, Korea, and colleagues present their research in an article titled "Tissue-Engineered Esophagus via Bioreactor Cultivation for Circumferential Esophageal Reconstruction". The authors created a two-layered tubular scaffold with an electrospun nanofiber inner layer and 3D-printed strands in the outer layer. After seeding human mesenchymal stem cells on the inner layer, constructs were cultured in a bioreactor, and a new surgical technique was used for implantation, including the placement of a thyroid gland flap over the scaffold. Efficacy was compared with omentum-cultured scaffolding technology, and successful implantation and esophageal reconstruction were achieved based on several metrics.

"Dr. Chung and colleagues from Korea present an exciting approach for esophageal repair using a combined 3D printing and bioreactor cultivation strategy," says Tissue Engineering Co-Editor-in-Chief John P. Fisher, PhD, Fischell Family Distinguished Professor & Department Chair, and Director of the NIH Center for Engineering Complex Tissues at the University of Maryland. "Critically, their work shows integration of the engineered esophageal tissue with host tissue, indicating a clinically viable strategy for circumferential esophageal reconstruction."

Credit: 
Mary Ann Liebert, Inc./Genetic Engineering News