PHILADELPHIA - Chronic Kidney Disease (CKD), which afflicts more than 26 million Americans, is a condition in which individuals experience a slow loss of kidney function over time. At the American Heart Association Scientific Sessions 2015, researchers from the Perelman School of Medicine at the University of Pennsylvania today presented findings from their analysis of the Chronic Renal Insufficiency Cohort (CRIC) study to evaluate risk markers for adverse cardiac events in patients with CKD.
Researchers analyzed CRIC data to identify whether the size of a patient's left atrium - one of the two upper chambers of the heart - is an indicator of potential heart failure and death among those with chronic kidney disease. Evaluating data collected from 2,936 CKD patients, researchers concluded that left atrial size is in fact a risk marker for heart failure.
"One of the main purposes of the CRIC study is to identify novel risk factors for cardiovascular events in CKD patients," said the study's lead author, Payman Zamani, MD, MTR, a heart failure physician and instructor of Medicine in Penn's Heart Failure and Transplant Cardiology Program. "We know that patients with CKD are at high-risk for cardiovascular events in general, but we need better tools to identify which CKD patients are at the highest risk. Left atrial size is an easily quantifiable metric that provides prognostic information in non-CKD patients, so we evaluated this patient population to determine if it is also an indicator of risk in those with CKD. Our analysis shows that larger left atrial size is associated with an increased risk of heart failure."
The team adjusted their data analysis to account for the influence of race and gender, as well as other known markers of heart failure risk such as hypertension. The analysis demonstrates that left atrial size continued to provide additional risk information in these high-risk patients.
Source: University of Pennsylvania School of Medicine