image: Schematic overview of the screening for cytoprotective kinase inhibitors in proteotoxicity-induced cell death
The Korea Brain Research Institute (KBRI, President Pann Ghill Suh) announced on November 12 that korean research team made up of Dr. Hyung-Jun Kim and Shinrye Lee of KBRI, and professor Kiyoung Kim of Soonchunhyang University, found a new molecular mechanism of suppressing neuronal toxicity associateded dementia and Lou Gehrig's disease.
These findings were published in the November issue of Autophagy (IF=11.059). The authors' names and the title of the paper are as follows.
Paper: PTK2/FAK regulates UPS impairment via SQSTM1/p62 phosphorylation in TARDBP/TDP-43 proteinopathies
Authors: Shinrye Lee (first author), Yu-Mi Jeon, Sun Joo Cha, Seyeon Kim, Younghwi Kwon, Myungjin Jo, You-Na Jang, Seongsoo Lee, Jaekwang Kim, Sang Ryong Kim, Kea Joo Lee, Sung Bae Lee, Kiyoung Kim*, Hyung-Jun Kim*(corresponding author*)
Neurons in patients with dementia or Lou Gehrig's disease often have abnormal aggregates that contain TDP-43* protein, and these accumulated aggregates can cause neurodegeneration by interupting ubiquitin proteasome system (UPS) that removes damaged or unnecessary proteins.
UPS(Ubiquitin proteasome system): It is a part of protein quality control system (mechanism that removes or restores abnormal proteins to ensure a certain protein performs its intended function). It is known that UPS prevents cell death by degrading abnormal proteins in damaged neurons.
TDP-43 : Protein that contributes toward maintaining the function and safety of RNA. It is known as a major disease-related protein in amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration dementia (FTD) and Alzheimer's disease (AD).
The research team found a new role of three proteins (PTK2, TBK1, SQSTM1) which can inhibit neuronal degeneration by TDP-43 and demonstrated for the first time that their interaction can alleviate neurodegeneration by strengthening "autophagy lysosome pathway (ALP),*" which consists of another protein quality control system in case of damage to the UPS.
This research is regarded as one that presents new therapeutic strategies that can remove abnormal protein accumulation in the neurons of patients with dementia in the future by revealing a new molecular mechanism that restores neurodegeneration by TDP-43 protein, which has been the major cause of dementia and Lou Gehrig diseases.
Hyung-Jun Kim, the principal researcher at KBRI and senior author of the study, said, "this research reveals the pathogenesis of TDP-43 associated neurodegeneration at the basic level, so further clinical verification process is necessary to develop a therapy for dementia." He added, "we will proceed follow-up research to verify the mechanism in actual patient tissues in cooperation with brain banks and hospitals at home and abroad."
The Korea Brain Research Institute signed an MOU with the Dementia Research Institute of King's College at London (UK DRI) in August to analyze the etiology using the blood and brain tissues of patients. Research for verification based on human-originated resources will start next year.