Promising new therapy with a dual mechanism of action to eliminate cancer stem cells and activate the immune system now in clinical development
Findings show a reactivation of the anti-cancer alarm system and draw parallels between embryogenesis and cancer
Combining LIF-neutralizing antibodies with immunotherapy promotes tumor regression, triggers immune memory, and increases survival in animal models
Montreal, June 11, 2019 - Researchers from the University of Montreal Hospital Research Centre (CRCHUM) have developed a two-step combination therapy to destroy cancer cells. In a study published in the journal Nature Communications, they show the superior therapeutic effectiveness of the "one-two punch" on cells of ovarian cancer patients, based on manipulation of the state of cellular aging.
CLEVELAND--Studying the sediment of a mountain river can reveal thousands of years or more of a waterway's history, including new threats from more frequent wildfires and increased precipitation brought by climate change.
And understanding those challenges may provide insight into other waterways, including the Cuyahoga River.
The prime predators of the Baltic Sea at the top of the food web are losing weight, according to a new study that links the deteriorating health of gray seals and cod with changes in bottom-living crustaceans, isopods and amphipods.
"It is important that you understand how the food web works when managing a fishery. It is not enough to manage how the fish and fisheries are changing. The availability and quality of food is at least as important", says Lena Bergström, researcher at the Department of Aquatic Resources at the Swedish Agricultural University.
Researchers at Chalmers University of Technology, Sweden, have discovered a completely new way of capturing, amplifying and linking light to matter at the nanolevel. Using a tiny box, built from stacked atomically thin material, they have succeeded in creating a type of feedback loop in which light and matter become one. The discovery, which was recently published in Nature Nanotechnology, opens up new possibilities in the world of nanophotonics.
University of Colorado Boulder researchers have developed nanobio-hybrid organisms capable of using airborne carbon dioxide and nitrogen to produce a variety of plastics and fuels, a promising first step toward low-cost carbon sequestration and eco-friendly manufacturing for chemicals.
By using light-activated quantum dots to fire particular enzymes within microbial cells, the researchers were able to create "living factories" that eat harmful CO2 and convert it into useful products such as biodegradable plastic, gasoline, ammonia and biodiesel.
In an unexpected discovery from the South Island (New Zealand), two species of narrowly distributed macro-moths were described as new species. Interestingly, both Arctesthes titanica and Arctesthes avatar were named after mythological deities and top-grossing blockbusters by famous filmmaker James Cameron: Titanic and Avatar, respectively.
On the land where Cordoba is located in the 21st century, two cities coexisted in the past, each on a hill. An Iberian city was located where Cruz Conde Park lies today, and a Roman city, which was founded at a later time, was located about 500 meters away. Archaeology has had to depend upon geological studies up to now in order to determine how the city developed throughout history, but now, thanks to LiDAR technology, 3D images have been obtained that show what the land was like where Cordoba lies before humans arrived.
Osaka, Japan - Polypropylene (PP) is everywhere, being one of the most widely used plastics in human life. A versatile material, its naturally inert surface can be modified for specific applications. Researchers at Osaka University have now developed a convenient light-driven process for oxidizing PP without harmful waste.
Circadian rhythms are 24 hour cycles that are guided by exposure to alternating periods of day and night. These cycles affect biological activities in a variety of living organisms which are attuned to the circadian clock. A disturbance in circadian patterns is known to affect many biomolecular processes linked with metabolism and other physiological functions. Dr. Tobias Eckle and his team at the University of Colorado Anschutz Medical Campus have studied circadian rhythms in detail.