Researchers from Russia, the Netherlands, Sweden, and the U.S. have revealed the structure of the protein responsible for vitamin B12 import into the cells of the bacterium that causes tuberculosis. The research findings were published in Nature.
Vitamin B12, also known as cobalamin, is vital to the proliferation of Mycobacterium tuberculosis, which causes TB. But while that vitamin can be synthesized internally, it is much easier for the pathogen to import B12 from the environment, and cobalamin consumption by the bacterium is directly associated with TB progression.
Tejas Patil, MD, is a medical oncologist. Lisa Ferrigno, MD, MPH, FACS, is a trauma surgeon. Working with lung cancer patients at University of Colorado Cancer Center, they both, independently, noticed something strange: A small percentage of patients taking high doses of the drug osimertinib (Tagrisso) were developing a rare twist in the right side of their colon, a condition called cecal volvulus.
Reef fish species uniquely respond to climate change, with some more vulnerable than others.
Five Great Barrier Reef fish species each activated different genetic responses to a marine heatwave in the Australian summer of 2015-16. This finding could help further understanding of climate change impacts on wild fish distributions.
Kanazawa, Japan - Concrete is the most widely used building material in the world and consequently is being continuously developed to fulfill modern-day requirements. Efforts to improve concrete strength have led to reports of porosity-free concrete (PFC), the hardest concrete tested to date. Some of the basic properties of PFC have already been explored, and now a team including Kanazawa University has probed the impact response of this innovative material. Their findings are published in International Journal of Civil Engineering.
BUFFALO, N.Y. -- Scientists have created a new database to help track the impacts of climate change on fish living in rivers, lakes and other inland waters throughout the world.
The Fish and Climate Change Database -- or FiCli (pronounced "fick-lee") -- is a searchable directory of peer-reviewed journal publications that describe projected or documented effects of climate change on inland fishes.
DURHAM, N.C. -- Researchers from Duke University have devised a method for estimating the air quality over a small patch of land using nothing but satellite imagery and weather conditions. Such information could help researchers identify hidden hotspots of dangerous pollution, greatly improve studies of pollution on human health, or potentially tease out the effects of unpredictable events on air quality, such as the breakout of an airborne global pandemic.
The results appear online in the journal Atmospheric Environment.
"The results of this vaccine trial are also important and promising with regard to the development of a vaccine against SARS-CoV-2, the new coronavirus," explains Prof. Marylyn Addo, Head of the Division of Infectious Diseases at the UKE and scientist at the DZIF. "The development of the MERS vaccine provides a basis upon which we at the DZIF can rapidly develop a vaccine against the new coronavirus."
In May 2018 Kīlauea volcano on the island of Hawaii erupted, touching off months of intense activity. Through August, incandescent lava from fissures spewed hundreds of feet in the air, and billowing ash clouds reached as high as six miles into the atmosphere. Huge lava flows inundated land up and down the Pacific island's southeast coast, destroying hundreds of homes.
RESEARCH TRIANGLE PARK, N.C. -- Researchers say a new discovery on a U.S. Army project for optoelectronic devices could help make optical fiber communications more energy efficient.
Oncotarget Volume 11 Issue 16 showed that the sensitivity of H1299 and A549 cells to concomitant treatment with PAC and WFA was greater than that of either PAC or WFA alone.