Lipoma is relatively common in the colon but is less often in the small intestine. Most lipomas are incidentally detected at endoscopy and are usually small and asymptomatic. However, some of them can present with obstruction and/or intussusceptions. Surgical resection is commonly recommended to remove such significant lipomas with a limited pedicle and larger than 2 cm in size, as endoscopic resection may result in unfavorable complications such as intestinal perforations.
A research article to be published on April 7, 2010 in the World Journal of Gastroenterology addresses this question. The endoscopic submucosal dissection (ESD) technique was used to remove a large lesion en bloc.
Their results showed large ileal lipoma can be completely removed with the modified ESD procedure in combination with endoscopic unroofing technique (from the top to the bottom like peeling a banana).