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Amsterdam, July 15, 2021 - Huntington's Disease (HD) is a progressive neurodegenerative condition characterized by motor, cognitive, and psychiatric symptoms, and motor symptoms are often preceded by cognitive changes. Recent evidence indicates that autophagy plays a central role in synaptic maintenance, and the disruption in autophagy may be at the root of these early cognitive changes.
(LOS ANGELES) - Many bodily functions in humans are manifested by mechanical deformations to the skin - from the stretching, bending and movement of muscles and joints to the flutter of a pulse at the wrist. These mechanical changes can be detected and monitored by measuring different levels of strain at various points throughout the body.
A team of researchers from Stanford University and the University of Leuven in Belgium has further elucidated an intriguing process that could be an important step toward a methanol fuel economy with abundant methane as the feedstock, an advance that could fundamentally change how the world uses natural gas.
Methanol - the simplest alcohol - is used to make various products, like paints and plastics, and as an additive to gasoline. Rich in hydrogen, methanol can drive new-age fuel cells that could yield significant environmental benefits.
Bottom Line: The investigational therapeutic ficlatuzumab in combination with chemotherapy showed signs of clinical efficacy in patients with relapsed/refractory acute myeloid leukemia.
Journal in Which the Study was Published: Blood Cancer Discovery, a journal of the American Association for Cancer Research
Author: Senior author Charalambos Andreadis, MD, professor of clinical medicine at the University of California, San Francisco (UCSF), and first author Victoria Wang, MD, PhD, an assistant professor of hematology and oncology at UCSF
Teens' ability to empathize -- to understand others' perspectives and emotions, and to care for their wellbeing -- is an important contributor to their relationships, including with friends. Prior research shows that teens who have more secure family relationships report higher levels of empathy for others. But little research examines whether teens with more secure family relationships actually show greater empathy when observed in real-life interactions with peers, or whether their empathic capacities show different patterns of growth over time.
In lab tests, Imperial researchers have created a metal-based molecule that inhibits the build-up of a peptide associated with Alzheimer's disease.
A peptide is a fragment of a protein, and one of the key hallmarks of Alzheimer's disease is the build-up of a specific peptide known as amyloid-β. The team demonstrated that with the aid of ultrasound, their molecule can cross the blood-brain barrier in mice, targeting the part of the brain where the damaging peptide most often accumulates.
Americans tend to be far more consumed with national politics than with local politics. As places like Utah, Arizona, Michigan and Maryland gear up to hold local elections this summer and fall, history predicts that they will see an average of 29-37% fewer voters than they would were their elections held "on cycle," in tandem with state and federal elections.
This apparent indifference to local policies can have serious consequences, according to BYU research recently published in the American Political Science Review.
A team of University of Houston pharmaceutical researchers is reporting a newly recognized process of drug metabolism in the intestines - followed by recycling through the liver - that could have important implications for developing treatments for intestinal diseases and for taking multiple medications at the same time.
Firefighters battling wildfires in the western United States use a variety of suppression tactics to get the flames under control. Prescribed burns, or controlled fires intentionally set to clear shrubs and forest litter before a wildfire ever ignites, can make fire suppression operations almost three times as effective in limiting wildfire severity, according to a new study by researchers from Penn State, the U.S. National Park Service and the U.S. Forest Service.
Antimicrobials are used to kill or slow the growth of bacteria, viruses and other microorganisms. They can be in the form of antibiotics, used to treat bodily infections, or as an additive or coating on commercial products used to keep germs at bay. These life-saving tools are essential to preventing and treating infections in humans, animals and plants, but they also pose a global threat to public health when microorganisms develop resistance to them, a concept known as antimicrobial resistance.
To extract the polarization information of incident light, polarization-sensitive photodetectors (PSPDs) exhibit significant practical application in both military and civil areas, like bio-imaging, remote sensing, night vision, and helmet-mounted sight for fighter plane. Optical filters combined with polarizers are usually needed for traditional photodetectors to realize polarized light detection. But it will increase the size and complexity of devices.
New research from the University of Georgia finds that older Mexican Americans who live in low English-speaking neighborhoods are at greater risk for poor health and even an early death.
Language barriers can be a significant deterrent to health. People who don't speak English well are less likely to seek health care or receive health information. This can lead to delay of care and missed health screenings for chronic disease and cancers. Language isolation is also linked to poor mental health.
Children exposed to elevated levels of air pollution may be more likely to have poor inhibitory control during late childhood and poor academic skills in early adolescence, including spelling, reading comprehension, and math skills. Difficulty with inhibition in late childhood was found to be a precursor to later air pollution-related academic problems. Interventions that target inhibitory control might improve outcomes.
The COVID-19 pandemic and the situations of stress and sadness associated with it have not significantly increased the prevalence of depression and anxiety among participants in the Brazilian Longitudinal Study of Adult Health (ELSA-Brazil) who live in the city of São Paulo.
Researchers from Kumamoto University, Japan have found that a component derived from turmeric essential oil, aromatic turmerone (ar-turmerone), and its derivatives act directly on dopaminergic nerves to create a neuroprotective effect on tissue cultures of a Parkinson's disease model. This appears to be due to enhanced cellular antioxidant potency from the activation of Nrf2.