The discovery of tumor-suppressor genes has been key to unlocking the molecular and cellular mechanisms leading to uncontrolled cell proliferation – the hallmark of cancer. Often, these genes will work in concert with others in a complex biochemical system that keeps our cells growing and dividing, disease free.
Now researchers at the University of North Carolina at Chapel Hill School of Medicine and UNC Lineberger Comprehensive Cancer Center have found that defects in one gene, called p18, may override the rest, eventually leading to cancer.