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Findings published today in the journal Science Translational Medicine suggest that a type of white blood cell called tumor associated macrophages (TAMs) that have been deceived by pancreatic cancer cells into not attacking them can be "re-programmed" by a specially designed molecule that activates a protein found on their surfaces.
Very little is known about how the onset of puberty is controlled in humans, but the discovery of a new gene in the roundworm C. elegans could be the "missing link" that determines when it's time to make this juvenile-to-adult transition. Two genes, LIN28 and MKRN3, are known to be associated with precocious puberty in humans, where juveniles as young as six may start developing adult features. These genes are found in all animals, including C. elegans, in which they also control the juvenile-to-adult transition.
Two distinct subtypes discovered, each with dramatically different risks of recurrence
Patients with more aggressive subtype can be monitored vigilantly for recurrence and possible treatment, while patients with the less aggressive subtype can be advised their prognosis is excellent
Parkinson's disease, a neurodegenerative disorder that affects more than 6 million people worldwide, is caused by the buildup of alpha-synuclein proteins in the brain. The biological function of alpha-synuclein is still not well understood, but because of its role in neurodegenerative diseases, researchers are actively studying this protein to understand the mechanisms of the disease and to look for new treatment strategies.
The UN's Sustainable Development Goal 7 (SDG 7) aims to ensure access to affordable, reliable, sustainable, and modern energy for all by 2030. Access to electricity services is of course a key priority under this goal, particularly due to the strong interconnections it has with other development objectives. Sub-Saharan Africa remains the region with the largest electricity access deficit in the world with nine out of ten people living without electricity in 2030 projected to be in this region, despite progress in terms of expanding access to electricity.
New research published in the European Journal of Neurology indicates that an active sexual life is linked with lower disability and better quality of life in men with early Parkinson's disease.
The analysis included a subgroup of 355 patients from the PRIAMO (PaRkinson dIseAse non MOtor symptoms) study, who were followed for two years.
Chief executives who speak out on political issues and take a principled stance are increasingly sought out by jobseekers who believe such behaviour signals fair treatment, respect for employees, and a more responsible vision beyond nurturing the bottom line, new research shows.
People are over 20% more likely to want to work for a company where the CEO takes a humanistic stance on a political issue unrelated to their business, new research by the University of Bath's School of Management, Audencia Business School in France, and London's Imperial College, shows.
Hesperos Inc., pioneers of the "human-on-a-chip" in vitro system has announced the use of its innovative multi-organ model to successfully measure the concentration and metabolism of two known cardiotoxic small molecules over time, to accurately describe the drug behavior and toxic effects in vivo. The findings further support the potential of body-on-a-chip systems to transform the drug discovery process.
Cancer is a leading cause of death in ageing populations. Despite decades of research, cancer treatments are still inefficient and have unacceptable side effects that continue to prompt an urgent need for new approaches to prevention and treatment. Uncovering novel anti-cancer mechanisms would fill current knowledge gaps and help meet this need.
Bats are unusual mammals with the ability to fly and have long lifespans. In addition, bats have a low incidence of cancer, but the reason for this has so far remained unclear.
In a world first, scientists have found a new way to direct stem cells to heart tissue. The findings, led by researchers at the University of Bristol and published in Chemical Science, could radically improve the treatment for cardiovascular disease, which causes more than a quarter of all deaths in the UK (1).
To date, trials using stem cells, which are taken and grown from the patient or donor and injected into the patient's heart to regenerate damaged tissue, have produced promising results.
A particularly aggressive, metastasizing form of cancer, HER2-positive breast cancer, may be treated with nanoscopic particles "imprinted" with specific binding sites for the receptor molecule HER2. As reported by Chinese researchers in the journal Angewandte Chemie, the selective binding of the nanoparticles to HER2 significantly inhibits multiplication of the tumor cells.
Philadelphia, July 3, 2019 - Treatment of psychosis can be targeted to a specific genetic mutation in patients with psychotic disorders, according to a study in Biological Psychiatry, published by Elsevier. The study provides a proof-of-principle demonstration that treatments can be tailored to a specific genotype, rather than diagnosis, to relieve symptoms.
Global warming is a serious threat to the planet and the living beings. One of the main cause of global warming is the increase in the atmospheric CO2 level. The main source of this CO2 is from the burning of fossil fuels in our daily lives (electricity, vehicles, industry and many more).
Understanding the structure and metabolism of cells and living organisms is essential for the development of new drugs and diagnostics. The availability of chemical tools that allow scientists to edit biomolecules, like proteins, with atom-level resolution have greatly contributed to the progress of chemical biology.