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TAMPA, Fla. -- Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults. One in four new leukemia cases are CLL. Early-stage CLL patients often do not require therapy, but for those with aggressive disease or who have failed previous treatments, a targeted therapy approach may be necessary. One such targeted therapy is PI3K inhibitors, which are drugs that block a specific protein that controls cell growth.
New research has demonstrated that kidneys can be revived prior to transplantation by delivering a cell therapy directly to the organ.
A team led by Newcastle University researcher, Dr Emily Thompson, is the first to discover that a new technique called Normothermic Machine Perfusion - when combined with stem cells - can be used to improve the function of 'marginal' kidneys, organs that are at risk of not working as well.
Recent NASA missions to asteroids have gathered important data about the early evolution of our Solar System, planet formation, and how life may have originated on Earth. These missions also provide crucial information to deflect asteroids that could hit Earth.
Missions like the OSIRIS-REx mission to Asteroid Bennu and the Hyabusa II mission to Ryugu, are often conducted by robotic explorers that send images back to Earth showing complex asteroid surfaces with cracked, perched boulders and rubble fields.
In November 2019, clinicians, health administrators, educators and researchers from around the world gathered in Toronto to discuss how to best address social determinants of health from a primary care perspective. Participants developed starting points for accessible and feasible actions to improve health equity in their own primary care setting. They emphasized strategies to incorporate community members, especially those with lived experiences of discrimination, in the health care design team.
Researchers affiliated with the Robert Graham Center for Policy Studies in Family Medicine and Primary Care conducted a descriptive bibliometric analysis to determine the gender ratio of scholarly authorship on publications by its researchers between 2008 and 2018. While the average gender ratio of RGC researchers across this period was 46.3 percent female to 56.4 percent male, gender disparities in authorship were much starker. For example, roughly two-thirds of 229 publications listed a male first author, and almost all had at least one male author.
NASA's Aqua satellite used infrared light to identify the strongest storms and coldest cloud top temperatures in Tropical Depression 6E. Aqua found a few small areas of strength but cooler sea surface temperatures are expected to weaken them.
Tropical Depression 6E formed in the Eastern Pacific Ocean by 5 p.m. EDT on July 13 and was located well to the southwest of Baja California Sur, Mexico.
A new radiotracer, 18F-SynVesT-2, can directly assess synaptic density changes in the brain, providing an objective and quantitative measure of disease progression after stroke. Research presented at the Society of Nuclear Medicine and Molecular Imaging 2020 Annual Meeting shows that the radiotracer may also offer a primary endpoint to evaluate treatment efficacy of novel therapeutics for stroke in clinical trials.
Biochemists at Martin Luther University Halle-Wittenberg (MLU) have used a standard electron cryo-microscope to achieve surprisingly good images that are on par with those taken by far more sophisticated equipment. They have succeeded in determining the structure of ferritin almost at the atomic level. Their results were published in the journal PLOS ONE.
Researchers from the Peter the Great St.Petersburg Polytechnic University (SPbPU) discovered and theoretically explained a new physical effect: amplitude of mechanical vibrations can grow without external influence. Besides, the scientific group offered their explanation on how to eliminate the Fermi-Pasta-Ulam-Tsingou paradox.
An offhand remark by an acquaintance about using a smartphone. A joke about someone losing their memory or hearing. An ad in a magazine focused on erasing wrinkles or gray hair. An inner worry that getting older means growing lonely.
For drugs to be effective, they usually have to dock to proteins in the organism. Like a key in a lock, part of the drug molecule must fit into recesses or cavities of the target protein. For several years now, the team of the Macromolecular Crystallography Department (MX) at HZB headed by Dr. Manfred Weiss together with the Drug Design Group headed by Prof. Gerhard Klebe (University of Marburg) has therefore been working on building up what are known as fragment libraries.
Antibiotic resistance is a growing challenge in the treatment of infectious diseases worldwide. Bacteria become resistant to antibiotics by acquiring or mutating genes that allow them to survive the administration of antibiotics, which otherwise would kill them. However, this advantage in the presence of antibiotics can imply costs to bacteria when the drugs stop being administered. This occurs because resistance generally affects genes that are essential for the cell and so, once back to the original context, without antibiotics, bacteria stop being fit to compete for its own survival.
The COVID-19 pandemic presents an opportunity to transform food systems and achieve sustainable development. But the lively policy debate on which policy approach will promote agricultural development in Africa still prevents progress.
Debates include: Do small-scale farms have development potential or does supporting them promote 'romantic populism'? Are input subsidy programs an effective strategy to increase agricultural productivity? What role should the government play?
The world can expect more rainfall as the climate changes, but it can also expect more water to evaporate, complicating efforts to manage reservoirs and irrigate crops in a growing world, according to a Clemson University researcher whose latest work has been published in the journal Nature Communications.
A portable testing lab that fits into a suitcase is being hailed as the key to tackling one of the world's biggest dangers to health.
Experts from Newcastle University UK, have been working with the Addis Ababa Water and Sewerage Authority (AAWSA), Addis Ababa University (AAU) and the International Water Management Institute (IWMI) to ensure waterborne hazards can be identified in a quicker, easier and ultimately cheaper way, anywhere in the world.