Earth
FRANKFURT. Chronic liver disease and even cirrhosis can go unnoticed for a long time because many patients have no symptoms: the liver suffers silently. When the body is no longer able to compensate for the liver's declining performance, the condition deteriorates dramatically in a very short time: tissue fluid collects in the abdomen (ascites), internal bleeding occurs in the oesophagus and elsewhere, and the brain is at risk of being poisoned by metabolic products.
JUPITER, FL - A collaboration led by Scripps Research has developed a way to separate the beneficial anti-inflammatory properties of a group of steroids called glucocorticoids from some of their unwanted side-effects, through an optimization process they named "ligand class analysis."
Their process enabled them to engineer two new, drug-like compounds that show steroidal anti-inflammatory action and other specific traits. One boosts muscle and energy supply, while the other reduces risk of muscle-wasting and bone loss typical of such drugs.
TAMPA, Fla. -- Chimeric antigen receptor T-cell therapy, or CAR T, has been a breakthrough in the treatment of blood cancers such as acute lymphoblastic leukemia and diffuse large B-cell lymphoma. Clinical studies have shown overall response rates of more than 80% with an ongoing response of nearly 40% more than two years after therapy. However, the cellular immunotherapy doesn't work for every patient.
New research has found that men who have the Western world's most common genetic disorder are more likely to develop dementia, compared to those without the faulty genes.
Researchers at the University of Exeter and the University of Connecticut have previously found that men with two faulty genes that cause the iron overload condition haemochromatosis are more likely to develop liver cancer, arthritis and frailty, compared to those without the faulty genes.
Recent global calamities - the pandemic, wildfires, floods - are spurring interdisciplinary scientists to nudge aside the fashionable First Law of Geography that dictates "everything is related to everything else, but near things are more related than distant things."
CORVALLIS, Ore. - Extensive sea ice covered the world's oceans during the last ice age, which prevented oxygen from penetrating into the deep ocean waters, complicating the relationship between oxygen and carbon, a new study has found.
The lockdowns and reduced societal activity related to the COVID-19 pandemic affected emissions of pollutants in ways that slightly warmed the planet for several months last year, according to new research led by the National Center for Atmospheric Research (NCAR).
Northwestern University researchers have developed a new approach to quantum device design that has produced the first gain-based long-wavelength infrared (LWIR) photodetector using band structure engineering based on a type-II superlattice material.
RIVERSIDE, Calif. -- A team led by a biomedical scientist at the University of California, Riverside, reports a drug -- an estrogen receptor ligand called indazole chloride (IndCl) -- has the potential to improve vision in patients with multiple sclerosis, or MS.
New research reveals that the COVID-19 intensive care (ICU) mortality rate in Sweden was lower during the first wave of the pandemic than in many studies from other countries. And while analysis of individual underlying conditions found they were linked to mortality, an analysis looking at all these variables together found COVID-19 mortality in intensive care was not associated with underlying conditions, except for chronic lung disease.
COLUMBUS, Ohio - Antarctic ice is melting, contributing massive amounts of water to the world's seas and causing them to rise - but that melt is not as linear and consistent as scientists previously thought, a new analysis of 20 years' worth of satellite data indicates.
The analysis, built on gravitational field data from a NASA satellite system, shows that Antarctica's ice melts at different rates each year, meaning the models scientists use to predict coming sea level rise might also need adjusting.
Oncotarget recently published "Neuroendocrine carcinoma of uterine cervix findings shown by MRI for staging and survival analysis – Japan multicenter study" which reported that to investigate neuroendocrine carcinoma of the uterine cervix cases for MRI features and staging, as well as pathological correlations and survi
Michelle O'Malley(link is external) has long been inspired by gut microbes. Since she began studying the herbivore digestive tract, the UC Santa Barbara chemical engineering professor has guided several students to their doctoral degrees, won early and mid-career awards (including a recognition from President Obama), attained tenure and advanced to the position of full professor. She even had three children along the way. A constant through it all: goat poop.
Oncotarget published "The pro-apoptotic actions of 2-methoxyestradiol against ovarian cancer involve catalytic activation of PKCδ signaling" which reported that the authors have previously shown that a flaxseed-supplemented diet decreases both the incidence and severity of ovarian cancer in laying hens, also induces CYP1A1 expression in liver.
Recently, they have shown that as a biologically derived active component of flax diet, 2MeOE2 induces apoptosis in ovarian cancer cells which is partially dependent on p38 MAPK.
Each year, billions of tons of goods are transported globally using cargo containers. Currently, there are concerns that this immense volume of traffic could be exploited to transport illicit nuclear materials, with little chance of detection. One promising approach to combating this issue is to measure how goods interact with charged particles named muons - which form naturally as cosmic rays interact with Earth's atmosphere.