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Researchers at the University of Illinois at Urbana-Champaign have used molecular dynamics simulations to understand how sodium dodecyl sulfate causes protein unfolding. SDS is commonly used in labs to separate proteins and determine their molecular weights. However, it is still unclear how SDS influences protein structure.

The paper "Protein unfolding by SDS: the microscopic mechanisms and the properties of the SDS protein assembly" was published in Nanoscale.

For millennia, metallurgists have been meticulously tweaking the ingredients of steel to enhance its properties. As a result, several variants of steel exist today; but one type, called martensitic steel, stands out from its steel cousins as stronger and more cost-effective to produce. Hence, martensitic steels naturally lend themselves to applications in the aerospace, automotive and defense industries, among others, where high-strength, lightweight parts need to be manufactured without boosting the cost.

AUSTIN, Texas -- After a wild couple of months of equity market volatility, many mutual fund investors are now cautiously exploring how best to rebalance their portfolios. As they do so, new research from the McCombs School of Business at The University of Texas at Austin says they should keep an important factor in mind: taxable capital gains.

In a paper published in Science Advances, an international team of researchers have examined traits of marine megafauna species to better understand the potential ecological consequences of their extinction under different future scenarios.

Defined as the largest animals in the oceans, with a body mass that exceeds 45kg, examples include sharks, whales, seals and sea turtles.

Ionic channels -integral proteins in the cell membrane- are essential in several processes such as cardiac activity, nervous transmission, cell proliferation and the regulation of blood pressure. A study which has now been published in Science Advances describes for the first time the membrane traffic and association mechanisms of the Iks cardiac currents, a flow of potassium ions through ionic channels in the cell membrane which is decisive for the right cardiovascular function.

Abnormal levels of stress hormones such as adrenaline and cortisol are linked to a variety of mental health disorders, including depression and posttraumatic stress disorder (PTSD). MIT researchers have now devised a way to remotely control the release of these hormones from the adrenal gland, using magnetic nanoparticles.

This approach could help scientists to learn more about how hormone release influences mental health, and could eventually offer a new way to treat hormone-linked disorders, the researchers say.

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Below please find a summary and link(s) of new coronavirus-related content published today in Annals of Internal Medicine. The summary below is not intended to substitute for the full article as a source of information. A collection of coronavirus-related content is free to the public at http://go.annals.org/coronavirus.
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MISSOULA - The edge. Every athlete, from the professional to the weekend warrior, strives to obtain that ever-elusive element that leads to victory - sometimes sparing no expense to get there.

A lighter bike, a better training regimen, the newest shoes.

A recently released study from the University of Montana, however, has discovered that common "edge," sports nutrition products, are no more effective at promoting recovery in female athletes as regular, carbohydrate-rich, often less-expensive potato-based foods.

After comparing how infections from SARS-CoV-2 (which causes COVID-19) and two other human coronaviruses develop in cynomolgus macaques, researchers report that SARS-CoV-2 gives the animals a mild COVID-19-like disease. The results - based on a combination of experimental and historical infection data - suggest these animals are a promising model for testing COVID-19 therapeutics. Treatments for COVID-19 are urgently needed, as are animal models to test them. Which animal(s) can be used most precisely to model the efficacy of control measures in humans remains a question.

A recently developed system for switching on the activity of genes could improve treatments for a broad range of neurological diseases. Esteban Engel, a researcher in viral neuroengineering in the Princeton Neuroscience Institute, and his team have developed new gene promoters - which act like switches to turn on gene expression - that promise to broaden the ability to deliver large genes and keep them active for long periods of time.

The research was published online this week in the journal Molecular Therapy: Methods & Clinical Development.

In this Special Issue of Science, five Reviews highlight new insights into the impacts of drought on social, ecological and agricultural systems worldwide. Political fragmentation in how community water systems are managed in the United States contributes to disparities in water security in American communities and households, says Megan Mullin in one Review. Even though, by global standards, most Americans have reliable access to safe drinking water, access to clean water is still unequal within the country, particularly in the nation's rural and impoverished communities.

A single error in cell division related to the formation of a chromosome bridge can trigger a cascade of mutational events, rapidly generating many of the defining features of cancer genomes, a new study suggests. The findings provide a potential mechanistic explanation for the extreme genomic complexity and chromosomal rearrangements found in certain tumor types. It's been assumed that cancer genomes acquire their complexity gradually, accumulating small-scale changes over time through unavoidable errors during DNA replication.

Health and nutrition experts recommend that children do not consume drinks with added sugars or nonnutritive sweeteners, yet drinks containing both represent a major portion of beverages consumed by children. One reason may be that the labels of drinks marketed to kids do not help parents and other consumers differentiate among fruit juice and sugar-laden, artificially flavored drinks, finds research from NYU School of Global Public Health.

SINGAPORE, 16 April 2020 - A newly-discovered small protein in mitochondria is essential for energy production, report Duke-NUS researchers and their colleagues in the journal Nature Communications. Zebrafish lacking the small protein, which the scientists named BRAWNIN, have similar features to rare mitochondrial diseases in humans, suggesting further studies of the protein could help explain these conditions and identify possible therapies.

A support programme that aims to boost retention in the Armed Forces has received a positive research evaluation from Anglia Ruskin University (ARU), with military personnel reporting increased confidence in their employment prospects and increased goodwill towards the Armed Forces.

A pilot of the Spouse Employment Support (SES) programme was delivered from 2015-2017 by the Ministry of Defence to try and address some of the issues facing military spouses.