Culture
Researchers identify secretion mechanisms for a protein necessary for maintaining healthy connective
(Boston)--Researchers have discovered that a defective form of the protein aortic carboxypeptidase-like protein (ACLP) from patients with Ehlers-Danlos syndrome (EDS) is retained in cells and induces cellular stress. This finding may provide targets for pharmacologic and therapeutic interventions in treating individuals with EDS as well as wound healing disorders and fibrosis.
This itsy-bitsy robot can't climb up the waterspout yet but it can run, jump, carry heavy payloads and turn on a dime. Dubbed HAMR-JR, this microrobot developed by researchers at the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) and the Harvard Wyss Institute for Biologically Inspired Engineering, is a half-scale version of the cockroach-inspired Harvard Ambulatory Microrobot or HAMR.
About the size of a penny, HAMR-JR can perform almost all of the feats of its larger-scale predecessor, making it one of the most dexterous microrobots to date.
Scientists have tried to develop synthetic red blood cells that mimic the favorable properties of natural ones, such as flexibility, oxygen transport and long circulation times. But so far, most artificial red blood cells have had one or a few, but not all, key features of the natural versions. Now, researchers reporting in ACS Nano have made synthetic red blood cells that have all of the cells' natural abilities, plus a few new ones.
DURHAM, N.C. - Hundreds of published studies over the last decade have claimed it's possible to predict an individual's patterns of thoughts and feelings by scanning their brain in an MRI machine as they perform some mental tasks.
But a new analysis by some of the researchers who have done the most work in this area finds that those measurements are highly suspect when it comes to drawing conclusions about any individual person's brain.
GRAND RAPIDS, Mich. (June 3, 2020) -- Van Andel Institute scientists have for the first time described the near-atomic level structure of a molecular pathway that plays critical roles in human development, blood pressure regulation, inflammation and cell death. The findings were published today in the journal Nature.
The sacred oath taken by physicians during graduation from medical school to "First do no harm," the first words of the Hippocratic Oath, provides a strong impetus for a commentary just published in The American Journal of Medicine. Researchers from Florida Atlantic University's Schmidt College of Medicine and collaborators from the University of Wisconsin School of Medicine and Public Health are urging all health care providers to always prioritize compassion with reliable evidence on efficacy and safety.
New research from University of Alberta microbiologists has shed new light on how the respiratory syncytial virus (RSV)--one of the most common viral infections--breaks into our cells to cause infection.
One-third of American families have lost income since the beginning of shutdown triggered by the coronavirus pandemic, with such losses striking families from all economic groups, according to a new nationally representative survey by the RAND Corporation.
It begins with shortness of breath. And for approximately one third of patients, acute respiratory distress syndrome, or ARDS, ends in death. For those who survive, their lives are often turned upside-down. Michigan Medicine researchers have been investigating the downstream effects of ARDS for years. As the COVID-19 pandemic rages on, their work has relevance for hundreds of thousands of new patients.
Leesburg, VA, June 3, 2020--An open-access article in the American Journal of Roentgenology (AJR) details myriad practical updates that radiologists performing cross-sectional interventional procedures should institute to minimize risks for patients and imaging personnel alike during the coronavirus disease (COVID-19) pandemic.
UNIVERSITY PARK, Pa. --After the U.S. Census Bureau announced that it was changing how it protects the identities of individuals for the 2020 Census, a Penn State-led research team began to evaluate how these changes may affect census data integrity.
The Census Bureau is proposing to use differential privacy, a new method that attempts to protect the identities of individuals when publishing public data. Census data is used to distribute federal funding that impacts communities and also determines congressional representation.
Key Findings:
This is the first example of repairing a recessive gene mutation
Repairing a single mutation in the Tmc1 gene restored partial hearing in mice
The technique required the use of two viral vectors to deliver the base editing machinery
Cells with both vectors recovered 100 percent function
This technique opens the door to treating other genetic forms of hearing loss and other genetic diseases
Even among healthy people, a faltering memory is often an expected part of aging - but it's not inevitable.
"Some individuals exhibit remarkable maintenance of memory function throughout late adulthood, whereas others experience significant memory decline. Studying these differences across individuals is critical for understanding the complexities of brain aging, including how to promote resilience and longevity," said Alexandra Trelle, a postdoctoral research fellow at Stanford University.
A new survey conducted during the pandemic by researchers at the Johns Hopkins Bloomberg School of Public Health and the SNF Agora Institute at Johns Hopkins University found a more-than-threefold increase in the percentage of U.S. adults who reported symptoms of psychological distress—from 3.9 percent in 2018 to 13.6 percent in April 2020. The percentage of adults ages 18–29 in the U.S. who reported psychological distress increased from 3.7 percent in 2018 to 24 percent in 2020.
A Northern Arizona University professor co-authored a paper on the importance of springs in a drying climate that is in the inaugural climate change refugia special edition of Frontiers in Ecology and the Environment.