Culture
Hypoxia, or the inadequate oxygenation of a tissue, is a condition occurring frequently in all solid tumours such as melanoma skin cancer. Melanoma cells are not only able to survive oxygen deprivation, but also to use it to their own advantage by hijacking the anti-tumour immune response and developing resistance mechanisms to conventional anti-cancer therapies. A key gene responsible for cancer cell adaptation to hypoxia is HIF-1α (Hypoxia Inducible Factor-1 alpha).
A research group led by Professor Sachie Hiratsuka, Institute for Biomedical Research, Shinshu University, has found that a specific sequence of messenger RNA (mRNA), which exists outside cells, binds to receptors on the surface of natural killer (NK) cells and is taken up into the nucleus. The group found that NK cells with mRNA uptake are able to enhance their migration activity and interferon gamma production. Furthermore, NK cells incorporating the mRNA showed an inhibitory effect on cancer metastasis in animal experiments.
Special diets, exercise programs, supplements and vitamins, there is everywhere something supposed to help us live longer. Whether it actually works has not always been shown, but the average life expectancy of people has increased over the last 150 years. A study by an international team of researchers, including Claudia Fichtel and Peter Kappeler, scientists in the Behavioral Ecology and Sociobiology Unit at the German Primate Center (DPZ) - Leibniz Institute for Primate Research in Göttingen, indicates that we probably cannot slow down aging.
TEL AVIV, Israel and RALEIGH, NC, June 21, 2021, RedHill Biopharma Ltd. (Nasdaq: RDHL) ("RedHill" or the "Company"), a specialty biopharmaceutical company, today announced presentation of the positive Phase 2 safety and efficacy data for oral opaganib (Yeliva®, ABC294640) in hospitalized patients with COVID-19 pneumonia at the World Microbe Forum (WMF) 2021 (poster #: 5574).
Extreme heat waves in urban areas are much more likely than previously thought, according to a new modeling approach designed by researchers including University of Illinois Urbana-Champaign Civil and Environmental Engineering (CEE) assistant professor Lei Zhao and alumnus Zhonghua Zheng (MS 16, PhD 20). Their paper with co-author Keith W. Oleson of the National Center for Atmospheric Research, "Large model structural uncertainty in global projections of urban heat waves," is published in the journal Nature Communications.
An increasing number of studies on artificial intelligence (AI) are published in the dental and oral sciences but aspects of these studies suffer from a range of limitations. Standards towards reporting, like the recently published CONSORT-AI extension, can help to improve studies in this emerging field.
Forces of nature have been outsmarting the materials we use to build our infrastructure since we started producing them. Ice and snow turn major roads into rubble every year; foundations of houses crack and crumble, in spite of sturdy construction. In addition to the tons of waste produced by broken bits of concrete, each lane-mile of road costs the U.S. approximately $24,000 per year to keep it in good repair.
TAMPA, Fla (June 21, 2021) -- A blood gene profile associated with a high risk of dying from a severe lung disease can also predict poor outcomes in patients with COVID-19, a multicenter retrospective study led by the University of South Florida Health (USF Health) demonstrated. The risk profile based on 50 genes could help customize how COVID-19 is treated, improve allocation of limited health care resources such as intensive care beds and ventilators, and potentially save lives.
DURHAM, N.C. - In the fight against viruses, antibodies have the potential to either block infection or enable infection and make the disease worse, leading to concern about their use as a therapy for COVID-19.
A team of scientists from NUST MISIS and MIPT have developed and tested a new platform for realization of the ultra-strong photon-to-magnon coupling. The proposed system is on-chip and is based on thin-film hetero-structures with superconducting, ferromagnetic and insulating layers. This discovery solves a problem that has been on the agenda of research teams from different countries for the last 10 years, and opens new opportunities in implementing quantum technologies. The study was published in the highly ranked journal Science Advances.
WASHINGTON -- Although quantum technology has proven valuable for highly precise timekeeping, making these technologies practical for use in a variety of environments is still a key challenge. In an important step toward portable quantum devices, researchers have developed a new high-flux and compact cold-atom source with low power consumption that can be a key component of many quantum technologies.
The human intestine is made up of more than 40 square meters of tissue, with a multitude of folds on its internal surface that resemble valleys and mountain peaks in order to increase the absorption of nutrients. The intestine also has the unique characteristic of being in a continuous state of self-renewal. This means that approximately every 5 days all the cells of its inner walls are renewed to guarantee correct intestinal function.
LAWRENCE -- Tulsa may not be the first town one thinks of when talking about jazz, and flood management may not be the first vocation one compares to the musical genre. But the success Tulsa displayed in going from one of the nation's most flood-prone cities to a nationally recognized model of long-term risk reduction in just two decades is analogous to the evolution of one of the most American styles of music, a University of Kansas professor points out in a new study.
All coronaviruses produce four primary structural proteins and multiple nonstructural proteins. However, the majority of antibody-based SARS-CoV-2 research has focused on the spike and nucleocapsid proteins. A study published in PLOS Biology by Anna Heffron, Irene Ong and colleagues at the University of Wisconsin-Madison, USA, suggests that immune responses may develop against other proteins produced by the SARS-CoV-2 virus.
Think about how many different pieces of technology the average household has purchased in the last decade. Phones, TVs, computers, tablets, and game consoles don't last forever, and repairing them is difficult and often as expensive as simply buying a replacement.