Researchers studying the life threatening infectious disease sepsis have discovered how the infection can lead to a fatal inflammatory response through blood vessel cells. The research, which is published in EMBO Molecular Medicine, focuses on blocking crucial Matrix Metalloprotease enzymes (MMP) which activate the response.
Culture
ATS 2011, DENVER – Results from C91 "Late-Breaking Clinical Trials" on Tuesday afternoon, May 17, will bring new light to clinical problems and potential treatments. While five examine possible new therapies for people with asthma (pregnant women), emphysema, lymphangioleiomyomatosis (LAM), TB and chronic obstructive pulmonary disease (COPD), a sixth looks at the safety of physician- vs. nurse-led transport teams for critically ill patients,
Over the last 20 years, the number of hospital emergency departments in nonrural areas in the U.S. has declined by nearly 30 percent, with for-profit ownership, location in a competitive market, low profit margin and safety-net status associated with an increased risk of emergency department closure, according to a study in the May 18 issue of JAMA.
In an evaluation of contemporary antireflux therapies for chronic gastroesophageal reflux disease (GERD), most patients who received treatment with either the proton pump inhibitor esomeprazole or laparoscopic antireflux surgery achieved and remained in disease remission for 5 years, according to a study in the May 18 issue of JAMA.
Use of newer-generation antiepileptic drugs, which are also prescribed for bipolar mood disorders and migraine headaches, during the first trimester of pregnancy was not associated with an increased risk of major birth defects in the first year of life among infants in Denmark, according to a study in the May 18 issue of JAMA. Older-generation antiepileptic drugs are associated with an increased risk of birth defects.
(Boston) - Researchers from Boston University School of Medicine (BUSM) have discovered new details about the underlying mechanisms of skin hardening syndromes. The team connected pharmacological properties of the Novartis Pharma AG drug called balicatib to the skin disorder for the first time after investigating adverse reactions suffered by patients participating in a clinical trial for the treatment of osteoporosis. These findings appear online in the Journal of the American Academy of Dermatology.
TUCSON, Ariz. – A study conducted at the University of Arizona College of Pharmacy found that only 28 percent of pharmacies' clinical decision support software systems – the computer programs that are in place to alert pharmacists to possible medication problems – correctly identified potentially dangerous drug-drug interactions.
OTTAWA, May 17, 2011 - It is important for health care providers to report health issues, such as influenza outbreaks, to public health authorities. But there is evidence of a reluctance to share patient data for public health purposes due to concerns for both patient privacy and provider confidentiality. Dr. Khaled El-Emam and his research team at the CHEO Research Institute have developed a secure protocol and system that would solve this problem.
Since the smoking ban in restaurants, bars and nightclubs, customers are more aware of unpleasant smells, such as body odors and the smell of old beer, that used to be masked by cigarette smoke. Now science is looking at how the introduction of pleasant ambient scents that hide unwanted odors might enhance the nightlife experience.
ATS 2011, DENVER – Patients with chronic obstructive pulmonary disease (COPD) are more likely to increase physical activity on a day-to-day basis when exercises classes are combined with a confidence-building program, according to researchers from Michigan and Illinois. Those improvements, however, are only short-term and patients return to their original levels of activity once the confidence-building program ends, the study found.
The results of the study will be presented at the ATS 2011 International Conference in Denver.
A new study led by the University of Leicester has concluded that being able to see the GP of your choice in a doctor's surgery helps to reduce emergency hospital admissions.
The findings by researchers in the Department of Health Sciences at the University of Leicester revealed a correlation between patients being able to see a preferred GP and emergency hospital admissions.
The research, published in Emergency Medical Journal, was led by Dr John Bankart, a research fellow in medical statistics at the University. The research was funded by the NHS.
Amsterdam, 17 May, 2011 - New analysis published by the UK journal Reproductive Health Matters shows that the criminalisation of abortion in Poland has led to the development of a vast illegal private sector with no controls on price, quality of care or accountability. Since abortion became illegal in the late 1980s the number of abortions carried out in hospitals has fallen by 99%. The private trade in abortions is, however, flourishing, with abortion providers advertising openly in newspapers.
Do we buy things because of their attributes, their price, or out of brand loyalty? This was one of the questions asked by researchers from the University of Seville (US), who studied families' behaviour in putting together their shopping basket. They did this by studying their consumption patterns for ground coffee and tomato puree.
17 May 2011 -- A reduction by half in the radiation dose to which cardiac patients are exposed during diagnostic perfusion imaging is now "feasible", according to an Israeli study.
Results from the study will be presented as a late-breaking trial at the International Conference of Non-Invasive Cardiovascular Imaging (ICNC) in Amsterdam (15-18 May). ICNC is now one of the world's major scientific events in nuclear cardiology and cardiac CT imaging.
OAK BROOK, Ill. – A simple blood test may help prevent a serious complication associated with a contrast agent commonly used in MRI exams, according to a study published in the July issue of Radiology.
Within the past five years, use of gadolinium-based contrast agents (GBCA) has been linked to the development of nephrogenic systemic fibrosis (NSF), a rare disorder mainly affecting patients with severe kidney disease. But since 2008, restrictive GBCA administration guidelines implemented by Massachusetts General Hospital have proven effective in preventing NSF.