Researchers suggest that application of Nobel-prize-winning portfolio theory could provide objective funding allocations that would improve risk/reward trade-off in years of life lost.
The National Institutes of Health (NIH) is one of the largest investors in biomedical research—spending approximately $30 billion dollars annually—and must constantly evaluate how to spend those dollars in a way that adequately reflects multiple factors including disease burden.
PHILADELPHIA -- HIV patients treated with genetically modified T cells remain healthy up to 11 years after initial therapy, researchers from the Perelman School of Medicine at the University of Pennsylvania report in the new issue of Science Translational Medicine. The results provide a framework for the use of this type of gene therapy as a powerful weapon in the treatment of HIV, cancer, and a wide variety of other diseases.
Australian researchers are calling for the open sharing of clinical trial data in the medical research community, saying it would be instrumental in eliminating bottlenecks and duplication, and lead to faster and more trustworthy evidence for many of our most pressing health problems.
Moreover, hackers should be role models for freeing up access to the "source code" of clinical trials – patient-level data – the researchers from the University of New South Wales (UNSW) in Sydney argue in a commentary published in the journal Science Translational Medicine.
Middle-aged and older adults with diabetes showed substantial survival rates in a new University of Michigan Health System study of retirees.
Survival rates were strong even for adults living in nursing homes or who have multiple health issues like dementia and disabilities that make self-managed care for diabetes difficult.
ANN ARBOR, Mich.—African-Americans with HIV are much less likely to adhere to drug therapy than others with the disease, according to a University of Michigan study.
Moreover, untreated depression may greatly hinder adherence to antiretroviral therapy (ART) for all low-income, HIV-infected patients, regardless of race.
ANN ARBOR, Mich.—New research shows that 40 percent of older Americans postponed retirement in the wake of the Great Recession.
The research, presented at the annual meeting of the Population Association of America, is the first to link actual data on household wealth just before and after the downturn to the retirement plans of a nationally representative sample of Americans age 50 and older.
On a comparative basis, use of the Pressure Right® acupressure device with ondansetron and dexamethasone was more reliable in PONV management effectiveness than the antiemetic drugs alone
Evidence-based study finds adjunctive use of Pressure Right® device enhanced the efficacy of the most commonly used prophylactic antiemetic drug combination
Azti-Tecnalia, the R+D centre that specialises in marine and foodstuff research, has for the first time developed an in-house, scientific project to identify and study food trends. Knowing the trends constitutes a great opportunity for the agri-food industry to promote innovation in foodstuffs and anticipate consumer demands.
In the United States, a baby is born with a facial cleft every hour, of every day of the year! Such birth defects result from both gene mutations and environmental insults. PRDM16 is a transcription factor originally described as being aberrantly activated in specific types of leukemia's, and more recently as a master regulator of brown adipose tissue differentiation. In a study published in the April 2012 issue of Experimental Biology and Medicine, investigators have now shown that this transcription co-factor plays a critical role in development of the embryonic palate.
Lebanon, NH - Research led by vascular surgeons at Dartmouth-Hitchcock may offer new hope to sufferers of peripheral artery disease, the cause of nearly 60,000 lower-limb amputations annually, through the use of a patient's own stem cells.
Richard J. Powell MD, chief of vascular surgery at Dartmouth-Hitchcock, is the principal investigator on a national study – involving 550 patients at 80 sites around the country – of so-called "no option" patients, for whom the disease is so advanced that amputation is the only available treatment.
New research confirms thrombus aspiration (TA) during percutaneous coronary intervention (PCI) in patients with acute ST-segment elevation myocardial infarction (STEMI) provides long-term outcomes similar to conventional intervention with bare-metal or drug-eluting stents.
Low dose whole body CT is nearly four times better than radiographic skeletal survey, the standard of care in the U.S., for determining the extent of disease in patients with multiple myeloma, a new study shows.
Boston – Cardiothoracic surgeons and endocrinologists from Boston Medical Center (BMC) have found that among patients undergoing coronary artery bypass graft (CABG) surgery, achieving Surgical Care Improvement Project (SCIP) benchmarks for glycemic control may be irrelevant when perioperative continuous insulin infusion protocols are implemented. These findings will be presented at the Annual meeting of the American Association for Thoracic Surgery on May 1 in San Francisco, CA.
People with good hearing also have a keen sense of touch; people with impaired hearing generally have an impaired sense of touch. Extensive data supporting this hypothesis was presented by Dr. Henning Frenzel and Professor Gary R. Lewin of the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch, Germany. The two researchers showed that both senses – hearing and touch – have a common genetic basis.
CHICAGO – Clinical studies registered in clinicaltrials.gov between 2007-2010 are dominated by small, single-center trials and contain significant heterogeneity (different in nature, difficult to compare) in methodological approaches, including the use of randomization, blinding, and data monitoring committees, according to a study in the May 2 issue of JAMA.