A cluster of human plague cases over a 10-year period in the seaport city of Mahajanga, Madagascar after a 62-year plague-free period provided researchers from Arizona and Madagascar with an opportunity to study plague dynamics in an urban environment, especially since historically plague entered new geographic areas through port cities such as this.
Most of the isolates found during the outbreak were very closely related, suggesting that a single introduction became established in Mahajanga and then underwent local cycling and differential.