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Eribuli: Positive effects predominate in certain patients, negative effects in others

Eribulin (trade name: Halaven) is approved for women with locally advanced or metastatic breast cancer in whom the disease has progressed despite prior drug therapy. The German Institute for Quality and Efficiency in Health Care (IQWiG) examined in a dossier assessment whether the drug offers an added benefit over the appropriate comparator therapy in these patient groups.

According to the findings, there are both positive and negative effects. There is proof of minor added benefit for one group of patients. For other groups, there are hints or indications of lesser benefit.

Actions versus objects: The role of the motor system

Amyotrophic lateral sclerosis (ALS) is a very severe disease that mainly affects the motor system. Recently the focus of public attention thanks to a viral campaign (remember last summer's ALS Ice Bucket Challenge?), ALS leads to progressive paralysis and ultimately death. Among the lesser known symptoms of the disease are cognitive impairments, which may even involve full-blown dementia. One of them is a selective difficulty in understanding and using verbs denoting actions, which these patients find much more challenging to process compared to nouns denoting objects.

Myriad myPath™ Melanoma improves diagnosis and treatment plans

SALT LAKE CITY, Utah, Nov. 7, 2014 - Myriad Genetics, Inc. (Nasdaq: MYGN) today presented results from a prospective clinical utility study of its Myriad myPath Melanoma test at the 2014 American Society of Dermatopathology (ASDP) annual meeting in Chicago, Ill. Myriad myPath Melanoma is a genetic test that differentiates malignant melanoma from benign skin lesions across all major melanoma subtypes. Key findings of this clinical utility study included a 43 percent reduction in indeterminate diagnoses and a 49 percent change in physicians' treatment recommendations for patients.

2014's famous 'pollen vortex' didn't happen

ATLANTA, GA (November 7, 2014) - Last year's long, harsh winter was brutal, and caused some experts to predict the "polar vortex" would turn into the "pollen vortex," and make allergy sufferers more miserable than ever before. But the "pollen vortex" didn't happen - at least not everywhere.

According to a study presented at the American College of Allergy, Asthma and Immunology (ACAAI) Annual Scientific Meeting, the spring pollen count in Ontario, Canada was not higher than usual, and in fact, was down considerably - and far lower than at any other time in the previous 12 years.

Emergency supplies of epinephrine in schools save lives

ATLANTA, GA (November 7, 2014) - Millions of children across the country need emergency epinephrine at school because they could suffer a severe, potentially life-threatening allergic reaction (anaphylaxis) to food or an insect sting. As schools across the country implement policies to stock emergency epinephrine, some are seeing dramatic results.

Sense of meaning and purpose in life linked to longer lifespan

A UCL-led study of 9,050 English people with an average age of 65 found that the people with the greatest wellbeing were 30% less likely to die during the average eight and a half year follow-up period than those with the least wellbeing.

New drug for common liver disease improves liver health

An experimental drug aimed at treating a common liver disease showed promising results and potential problems in a multicenter clinical trial funded by the National Institutes of Health. The FLINT study found that people with nonalcoholic steatohepatitis (NASH) who took obeticholic acid (OCA) had improved liver health during that period, including decreased inflammation and fat in the liver and decreased body weight versus people receiving a placebo.

Drug treatment may help restore kidney function in patients with renovascular disease

Highlights

Harvard researchers genetically 'edit' human blood stem cells

Harvard Stem Cell Institute (HSCI) researchers at Massachusetts General (MGH) and Boston Children's hospitals (BCH) for the first time have used a relatively new gene-editing technique to create what could prove to be an effective technique for blocking HIV from invading and destroying patients' immune systems.

This is the first published report of a group using CRISPR Cas technology to efficiently and precisely edit clinically relevant genes out of cells collected directly from people, in this case human blood forming stem cells and T-cells.

Denying problems when we don't like the political solutions

DURHAM, N.C. -- There may be a scientific answer for why conservatives and liberals disagree so vehemently over the existence of issues like climate change and specific types of crime.

A new study from Duke University finds that people will evaluate scientific evidence based on whether they view its policy implications as politically desirable. If they don't, then they tend to deny the problem even exists.

Is injury due to violence a chronic disease?

ANN ARBOR, Mich. -- Teens and young adults who get seriously injured in an assault are nearly twice as likely as their peers to end up back in the emergency room for a violent injury within the next two years, a new University of Michigan Injury Center study finds.

The researchers call this repeating pattern of violent injury a reoccurring disease, but their landmark study also suggests potentially powerful opportunities to intervene in ways that could stop the cycle.

Diagnostic exhalations

Paramedics respond to a 911 call to find an elderly patient who's having difficulty breathing. Anxious and disoriented, the patient has trouble remembering all the medications he's taking, and with his shortness of breath, speaking is difficult. Is he suffering from acute emphysema or heart failure? The symptoms look the same, but initiating the wrong treatment regimen will increase the patient's risk of severe complications.

Allergy sufferers are allergic to treatment more often than you'd think

ATLANTA, GA (November 6, 2014) – Whether allergy sufferers have symptoms that are mild or severe, they really only want one thing: relief. So it's particularly distressing that the very medication they hope will ease symptoms can cause different, sometimes more severe, allergic responses.

Preterm birth rates hits 2020 goal 7 years early

The national preterm birth rate fell to 11.4 percent in 2013 – the lowest in 17 years -- meeting the federal Healthy People 2020 goal seven years early.

Oddly, despite this achievement the U.S. still received a "C" on the 7th annual March of Dimes Premature Birth Report Card because it fell short of the more-challenging 9.6 percent arbitrarily target set by the March of Dimes.

Multicenter study: Hospital medical errors reduced 30 percent with improved patient handoffs

Multicenter patient-safety study reduces injuries from hospital medical errors by 30% with improved handoff communications

I-PASS bundle improves safety, quality of care at nine medical centers