Influenza has a long history of being one of the most deadly diseases to afflict humanity, but what exactly makes it so dangerous?
Certainly one reason is that influenza viruses have a history of jumping from other animals to humans, which, when the trans-species virus is new to the human population, generally means that human immune systems have no natural resistance. Another reason is that influenza viruses, with their rapidly mutating single-strand RNA genomes, are highly variable over time.