Culture
San Diego - An interim analysis of a large phase 3 clinical trial found that the combination of ibrutinib plus rituximab was superior to standard treatment for patients age 70 and younger with previously untreated chronic lymphocytic leukemia (CLL). The trial met its primary endpoint of an improvement in progression-free survival (the length of time patients live before their disease worsens). The combination also improved overall survival, the trial's secondary endpoint.
Philadelphia, December 4, 2018 -- Using an animal model of chronic stress, researchers at The Ohio State University have shown that the immune cells of the brain, called microglia, hold unique signatures of chronic stress that leave the animal more sensitive to future stressful experiences, evident by increased anxiety and immune responses. Eliminating microglia so that these “stress memories” could not be maintained did not prevent the increased anxiety in response to later stress but did prevent the hypersensitive immune response.
Flexible working often leads to negative views from other employees, with 1/3 of all UK workers believing those who work flexibly create more work for others, while a similar proportion believe their career will suffer if they use flexible working arrangements, according to new research.
Rotaviruses, like all viruses, reproduce inside living cells. Making new viruses requires assembling replication factories via a complex, little known process that involves both viral and cellular components.
A new randomised trial of over 3000 people in The Lancet finds that sharing pictorial representations of personalised scans showing the extent of atherosclerosis (vascular age and plaque in the arteries) to patients and their doctors results in a decreased risk of cardiovascular disease one year later, compared to people receiving usual information about their risk.
Women who experience domestic violence and abuse (DVA) are more than twice as likely to seek emergency contraception as other women, according to a study by National Institute for Health Research (NIHR)-funded researchers at the University of Bristol and Queen Mary University of London, suggesting that requests for emergency contraception could be an important sign of abuse.
SAN DIEGO -- Mayo Clinic researchers have developed two new strategies that may improve the performance of chimeric antigen receptor therapy (CAR-T cell therapy) in treating cancer. They are presenting results of their preclinical research at the 2018 annual meeting of the American Society of Hematology in San Diego.
Reducing toxicity in CAR-T cell therapy
BLOOMINGTON, Ind. - In a new study, Indiana University scientists found toxic flame retardants in newly manufactured children's car seats, sparking concerns about children's health. Of the 18 children's car seats tested, 15 contained new or traditional hazardous flame retardant chemicals.
From companies trying to resolve data security risks to coastal communities preparing for rising sea levels, solving modern problems requires teamwork that draws on a broad range of expertise and life experiences. Yet individuals receive little formal training to develop the skills that are vital to these collaborations.
Leading scientists call for action to increase global soil carbon, in advance of the annual climate summit of the United Nations Framework Convention on Climate Change (UNFCCC) in Katowice, Poland (COP24) and World Soil Day (5 Dec).
The amount of carbon in soil is over twice the amount of carbon found in trees and other biomass.
But one-third of the world's soils are already degraded, limiting agricultural production and adding almost 500 gigatons of carbon dioxide to the atmosphere, an amount equivalent to the carbon sequestered by 216 billion hectares of U.S. forest.
DALLAS, December 3, 2018 --Full marathons may significantly raise concentrations of several biomarkers of strain on the heart, according to new research in Circulation, Journal of the American Heart Association.
The research, led by the University of Plymouth, examined the uptake of nanoparticles by a commercially important mollusc, the great scallop (Pecten maximus).
After six hours exposure in the laboratory, billions of particles measuring 250nm (around 0.00025mm) had accumulated within the scallop's intestines.
However, considerably more even smaller particles measuring 20nm (0.00002mm) had become dispersed throughout the body including the kidney, gill, muscle and other organs.
Sunday, Dec. 2, 2018, SAN DIEGO: At the American Society of Hematology (ASH) Annual Meeting, Cleveland Clinic medical hematologist and oncologist Aziz Nazha, M.D., will present results of a personalized prediction model that surpassed current prediction models for Myelodysplastic Syndromes (MDS).
A follow-up analysis of patients enrolled in a Phase I/II multi-center trial for diffuse large B-cell lymphoma (DLBCL) reported 51 percent of patients receiving an anti-CD19 chimeric antigen receptor (CAR T) called axi-cel were still alive two years post-treatment. Axi-cel was approved by the U.S. Food and Drug Administration for treatment of DLBCL in October 2017 and by the European Commission in August 2018.