Culture
Scientists have for the first time revealed the structure surrounding important receptors in the brain's hippocampus, the seat of memory and learning.
The study, carried out at Oregon Health & Science University, published today in the journal Nature.
The new study focuses on the organization and function of glutamate receptors, a type of neurotransmitter receptor involved in sensing signals between nerve cells in the hippocampus region of the brain. The study reveals the molecular structure of three major complexes of glutamate receptors in the hippocampus.
Stanford scientists' software turns 'mental handwriting' into on-screen words, sentences
Call it "mindwriting."
The combination of mental effort and state-of-the-art technology have allowed a man with immobilized limbs to communicate by text at speeds rivaling those achieved by his able-bodied peers texting on a smartphone.
Drug overdose deaths before, after shelter-in-place orders during COVID-19 pandemic in San Francisco
What The Study Did: Researchers describe overdose deaths in San Francisco before and after the initial COVID-19 shelter-in-place order to try to make clear whether characteristics of fatal overdoses changed during this time in an effort to guide future prevention efforts.
Authors: Luke N. Rodda, Ph.D., of the Office of the Chief Medical Examiner for the city and county of San Francisco, is the corresponding author.
What The Study Did: Researchers used registry data to examine the number, characteristics and outcomes of patients with sunburns severe enough to warrant admission to specialist burn services in Australia and New Zealand.
Authors: Lincoln M. Tracy, Ph.D., of Monash University in Melbourne, Australia, is the corresponding author.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jamadermatol.2021.1110)
What The Study Did: Delayed localized injection-site reactions to the Moderna COVID-19 vaccine for 16 patients are described in this report.
Authors: Alicia J. Little, M.D., Ph.D., of the Yale University School of Medicine in New Haven, Connecticut, is the corresponding author.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jamadermatol.2021.1214)
LA JOLLA, CALIF. - May 12, 2021 - Scientists at Sanford Burnham Prebys Medical Discovery Institute have taken a deep dive into a previously overlooked family of proteins and discovered that they are essential to maintaining the energy that cells need to grow and survive. The proteins, known as lipid kinases, produce messengers that help balance cellular metabolism and promote overall health. The findings, published in Developmental Cell, provide further support to pursue lipid kinases as promising therapeutic targets for diseases that demand excess energy, such as cancer.
Social anxiety disorder can cause considerable suffering in children and adolescents and, for many with the disorder, access to effective treatment is limited. Researchers at Centre for Psychiatry Research at Karolinska Institutet and Region Stockholm in Sweden have now shown that internet-delivered cognitive behavioural therapy is an efficacious and cost-effective treatment option. The study is published in the journal JAMA Psychiatry.
The acidity of the atmosphere is increasingly determined by carbon dioxide and organic acids such as formic acid. The second of these contribute to the formation of aerosol particles as a precursor of raindrops and therefore impact the growth of clouds and pH of rainwater. In previous atmospheric chemistry models of acid formation, formic acid tended to play a small role. The chemical processes behind its formation were not well understood.
Since the discovery of Alzheimer's disease over a century ago, two hallmarks of the devastating illness have taken center stage.
The first, known as amyloid plaques, are dense accumulations of misfolded amyloid protein, occurring in the spaces between nerve cells. Most efforts to halt the advance of Alzheimer's disease have targeted amyloid protein plaques. To date, all have met dispiriting failure.
Acetone, a volatile solvent used for everything from removing nail polish and cleaning textiles to manufacturing plastics, could get a sustainability boost from a new strain of bacteria engineered by a research team based in Japan.
They published the details of the heat-loving, acetone-producing bacteria called Moorella thermoacetica on April 23 in AMB Express.
PHILADELPHIA--A low-cost, rapid diagnostic test for COVID-19 developed by Penn Medicine provides COVID-19 results within four minutes with 90 percent accuracy. A paper published this week in Matter details the fast and inexpensive diagnostic test, called RAPID 1.0 (Real-time Accurate Portable Impedimetric Detection prototype 1.0).
The inhibition of pathological protein-protein interactions is a promising approach for treating a large number of diseases, including many forms of cancer. A team of researchers has now developed a bicyclic peptide that binds to beta-catenin--a protein associated with certain types of tumor. The secret of their success is the cyclic nature and the hairpin shape of the peptide, which mimics a natural protein structure, they report in the journal Angewandte Chemie.
In a new study from Lund University and the University of Gothenburg, patients were interviewed about their experiences ten years after undergoing obesity surgery. The results show that the effect on eating and weight regulation persisted, whereas other problems, such as feelings of guilt about still not being healthy enough, remained.
"This is one of few follow-ups from a patients perspective so long after surgery", says My Engström, researcher in nursing at the University of Gothenburg.
Mycobacterium tuberculosis is incredible in that it can survive for decades within its human host. It does this by varying its diet to successfully steal nutrients from the human host including immune cells; it is known to acquire and absorb multiple carbon sources from the body during infection.
The DNA sequences produced are also called oligonucleotides. These are widely used for disease identification, for the manufacture of oligonucleotide-based drugs, and for several other medical and biotechnological applications.
The high demand for oligonucleotides therefore requires an efficient automated method for their chemical production.This process relies on phosphoramidites, which are chemical compounds that have the disadvantage of being unstable unless stored at the ideal -20 degrees Celsius.