Culture
Cleveland Clinic researchers have identified for the first time an explanation of why patients with identical PTEN mutations often have vastly different clinical presentations.
In a new study published in JAMA Network Open, a team of researchers led by Charis Eng, MD, PhD, of Cleveland Clinic Lerner Research Institute's Genomic Medicine Institute, discovered that copy number variations (CNVs) may act as genomic modifiers that influence the risk of autism spectrum disorder (ASD) and/or developmental delay (DD) versus cancer risk in individuals with PTEN mutations.
Getting covered by health insurance may have a major impact on a low-income person's ability to get a job or enroll in school, according to a new study that gives the first direct look at the relationship between the two.
The percentage of low-income people enrolled in Michigan's Medicaid expansion program who had jobs or were enrolled in school jumped six points in one year, the study shows. That outpaced employment gains among the state's general population during that same time.
What The Study Did: Cancer registries representing about 28% of the U.S. population were used to examine how new cases of colorectal cancer increased from age 49 to 50, the age when many people of average risk for the disease historically began screening, although screening age recommendations vary.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
A year-by-year age analysis of colorectal cancer rates among U.S. adults finds a 46% increase in new diagnoses from ages 49 to 50, indicating that many latent cases of the disease are likely going undiagnosed until routine screenings begin at 50, according to a new study in JAMA Network Open.
In the first comparative clinical trial of lung cancer screening decision aid versus standard educational information, researchers from The University of Texas MD Anderson Cancer Center have shown that a decision aid delivered through tobacco quitlines effectively reaches a screening-eligible population and results in informed decisions about lung cancer screening.
CHICAGO (January 31, 2020): Virtual antibody crossmatching is a safe and efficient way of selecting kidney transplant recipients. Two years after implementing the process, the Medical University of South Carolina (MUSC) division of transplant surgery, Charleston, concluded that the technique was just as accurate and sensitive as physical crossmatch, the current gold standard, and much quicker.
Characterization of unique PMEPA1 gene splice variants (isoforms d and e) from RNA Seq profiling pro
The cover for issue 4 of Oncotarget features Figure 8, "Model for biological function categorization of PMEPA1 isoforms (c, d, and e) in the context of prostate cancer," by Sharad, et al.
Weightlifters could do less and get stronger by changing the amount they lift each session, according to new research.
Sports scientists from the University of Lincoln, UK, compared the average weights lifted by two groups over six weeks: one using a traditional training method of a "one rep max" - the maximum weight an athlete could lift - and one using a load velocity profile, where the weights were tailored so they lift either more or less at each session.
31 January 2020, Cambridge - Researchers at EMBL's European Bioinformatics Institute (EMBL-EBI) and Queen Mary University of London have led a study to categorise which genes are essential for supporting life. The results from this study could be a useful new resource to help researchers identify mutations responsible for rare childhood diseases.
CHAMPAIGN, Ill. -- Artificial sweeteners such as sucralose provide the seductive taste of sweetness without the calories contained in sugar - a seeming win-win for people who need to control their blood sugar and insulin levels or weight.
However, simply tasting or consuming sucralose may affect blood glucose and insulin levels on glucose tolerance tests, scientists at the University of Illinois found in a new study.
On January 24, 2020, the French Ministry of Health confirmed the first three cases of patients affected by the Wuhan coronavirus. On January 29, 2020, the Institut Pasteur, which is responsible for monitoring respiratory viruses in France, sequenced the whole genome of the coronavirus known as "2019-nCoV", becoming the first institution in Europe to sequence the virus since the start of the outbreak.
Simple sequence repeats (SSRs) are regions of DNA with high diversity, and they have long been a mainstay for botanists examining the genetic structure of plant populations. However, as the cost of sequencing DNA continues to plummet and genetic technologies advance, newer techniques for mapping genetic diversity such as genotyping-by-sequencing (GBS) or RAD-seq have begun to rival the traditional use of SSRs.
As well as sequencing the whole genome of coronavirus 2019-nCoV, the Institut Pasteur continued to work on the samples taken from the first confirmed cases. The quality of these initial samples enabled rapid cell-culture isolation of the new virus. The Institut Pasteur's scientists now have access to the virus responsible for the infection. The isolation of the virus paves the way for new diagnostic, therapeutic and prophylactic approaches.
Studies have shown a rapid increase in new cases of type 1 diabetes worldwide. However, scientists and researchers have struggled to identify a direct cause. Many have questioned if changes in the environment or lifestyle have impacted the disease. In a newly released review paper published in The Lancet Diabetes & Endocrinology, faculty from the Colorado School of Public Health at the Anschutz Medical Campus examined whether any environmental exposures can explain why type 1 diabetes is on the rise.
Therapeutic horseback riding combined with brain-building exercises can improve the dexterity, coordination and strength of children with neurodevelopmental disorders, shows a study in Frontiers in Veterinary Science.