Culture
The cover for issue 12 of Oncotarget features Figure 11, "Global analyses of the RNA-Seq data of LNCaP empty vector and LNCaP cells overexpressing hPCL3S (Clone 12)" by Abdelfettah, et al.
These proteins contain a TUDOR domain binding H3K36me3, two PHD domains and a Winged-helix domain involved in GC-rich DNA binding.
The human PCL3 locus encodes the full-length hPCL3L protein and a shorter isoform, hPCL3S containing the TUDOR and PHD1 domains only.
In the treatment of tumors, microenvironment plays an important role. It often contains immune cells that are so changed that they promote tumor growth. In the journal Angewandte Chemie, scientists have introduced a method by which cell samples from tumors and their surroundings can rapidly (under 1 hour) be cycled through staining, destaining, and then restaining with fluorescent antibodies--through attachment of a "black hole quencher" (fluorescence quencher) by means of "click chemistry".
A recent study from North Carolina State University finds that people who manage to balance living in the moment with planning for the future are best able to weather daily stress without succumbing to negative moods.
"It's well established that daily stressors can make us more likely to have negative affect, or bad moods," says Shevaun Neupert, a professor of psychology at NC State and corresponding author of a paper on the recent work. "Our work here sheds additional light on which variables influence how we respond to daily stress."
The worldwide spread of the coronavirus SARS-CoV-2 and its associated respiratory disease COVID-19 proceeds at a highly dynamic pace. The Leopoldina has convened an interdisciplinary group of scientists to investigate the current situation. The resulting ad-hoc statement 'Coronavirus Pandemic in Germany: Challenges and Options for Intervention' discusses potential health policy options to counter the coronavirus pandemic in Germany.
It is estimated that every year, over 100,000 human deaths can be attributed to snakebite from the world's 700 venomous snake species - all inflicted in self-defence when the snakes feel threatened by encroaching humans.
However, a new piece of research concludes that snake venom did not evolve as a defence mechanism.
Senior Lecturer Dr Wolfgang Wüster, a world-renowned expert on snake venom evolution at Bangor University's School of Natural Sciences explained:
On average, women live longer than men: About 90% of people reaching 110 years old or more are women. The current record holder is Jeanne Calment, who was 122 years old, when she died in 1997.
Now a new study shows, that even greater differences in lifespan are found in wild mammals. The average female wild mammal lives 18.6 % longer than her male counterpart. In humans the difference is "only" 7.8 %.
SAN FRANCISCO, Calif. - March 25, 2020 - While researchers are certain that coronavirus spreads through mucus and droplets expelled by coughing or sneezing, it is unclear if the virus is spread through other bodily fluids, such as tears. Today's just-published study offers evidence that it is unlikely that infected patients are shedding virus through their tears, with one important caveat. None of the patients in the study had conjunctivitis, also known as pink eye. However, health officials believe pink eye develops in just 1 percent to 3 percent of people with coronavirus.
WEST LAFAYETTE, Ind. - A 3D camera should be as easy to use as one found on a smartphone.
That is the guiding principle for a Purdue University professor with more than two decades of experience in the 3D imaging field, who has developed new technologies aimed at making 3D cameras easier to use.
Song Zhang, a professor of mechanical engineering in Purdue's College of Engineering, led a team to create technologies to help compress 3D camera files and automate focus and exposure settings.
HOUSTON -- Treating T cells harvested from a patient with a combination of an epigenetic drug and a cytokine while expanding the cells in the lab re-programs them into a stronger T cell type that persists longer than its comrades, researchers at The University of Texas MD Anderson Cancer Center report in Cancer Immunology Research, a journal of the American Association for Cancer Research.
Teeth constitute a permanent and faithful biological archive of the entirety of the individual's life, from tooth formation to death, a team of researchers has found. Its work provides new evidence of the impact that events, such as reproduction and imprisonment, have on an organism.
"Our results make clear that the skeleton is not a static organ, but rather a dynamic one," explains Paola Cerrito, a doctoral candidate in NYU's Department of Anthropology and College of Dentistry and the lead author of the paper, which appears in the journal Scientific Reports.
Unlocking the full potential of cannabis for agriculture and human health will require a co-ordinated scientific effort to assemble and map the cannabis genome, says a just-published international study led by University of Saskatchewan researchers.
In a major statistical analysis of existing data and studies published in the Annual Review of Plant Biology, the authors conclude there are large gaps in the scientific knowledge of this high-demand, multi-purpose crop.
As the world prioritizes social distancing to stop or slow down the spread of coronavirus (COVID-19), a new study by researchers at Florida Atlantic University demonstrates that mother-infant touch and contact are essential for optimal neurodevelopmental regulation in early infancy. Kangaroo Care, a skin-to-skin, chest-to-chest method of caring for a baby, especially one who is premature, has been associated with promoting neurophysiological development.
Analysis of human mobility and epidemiological data by a global consortium of researchers, led by the University of Oxford and Northeastern University, shows that human mobility was predictive of the spread of the epidemic in China. Restrictions of travel from Wuhan unfortunately came too late and research showed that the impact of travel restrictions declines as the epidemic grows. Provinces outside Hubei that acted early to test, track and contain imported COVID-19 cases fared the best at preventing or containing local outbreaks.
In 2007, Finnish Airedale Terrier breeders sent puppies that had died only a few days after being born for pathological examinations to the Finnish Food Safety Authority (Evira), the predecessor of the Finnish Food Authority. Some litters had lost several puppies. A research project initiated at Evira under the direction of Professor Marjukka Anttila uncovered a problem in the puppies' lungs.
The full title of the research is "The study of the mechanisms of effectiveness of T-cells CAR-T towards solid tumors"; it was supported by nonprofit RakFond (Cancer Fund) and CyStoreLab (a resident of Skolkovo).
Immunotherapy with genetically modified lymphocytes, such as CAR-T cells, is one of the most promising branches of modern fundamental and clinical oncology. A CAR-T cell is a T-lymphocyte with a gene encoding a chimeric antigen receptor, or CAR receptor, in its genome.