Culture
An international team of scientists has developed a novel genetic measure that could dramatically improve how doctors assess the risk of sustaining a fracture due to osteoporosis or fragility
A full genome profile can be generated for approximately £35-40 per patient, a cost that is comparable to or lower than the cost of an X-ray to measure bone mineral density
By generating a single genomic profile, researchers can also identify multiple risk factors for diseases like cancer, cardiovascular disease and osteoporosis
Both influenza virus M2, a proton-selective ion channel essential for efficient viral replication, and PB1-F2 protein, which localizes to the mitochondria and attenuates host antiviral immunity, are involved in the inflammatory response by stimulating NLRP3 inflammasome-dependent IL-1β secretion. However, the precise mechanisms by which these viral proteins activate the NLRP3 inflammasome remain unclear.
You may recognize yourself. You're part of a group where everyone seems to agree more or less all the time. You may disagree, but you'd rather not speak up, and the others aren't voicing any disagreement either.
These meetings are dominated by a few individuals, or maybe just one person. Everyone else nods and smiles at the chairperson, at least until you talk to them one-on-one. Then it turns out that you weren't the only one who had unspoken objections.
Study uses ridesourcing data to investigate the relationship between ridesourcing and public transit
It seeks to answer whether ridesourcing substitutes or complements public transit, and how the substitution effect changes over time and space
Study shows that the substitution effect is more common in the city center while complementary effect is more pronounced in the suburban areas
Human-resident microbes can influence both health and disease. Investigating the microbiome using next-generation sequencing(*1) technology has revealed examples of mutualism and conflict between microbes and humans.
Discovery of cooler planet brings astronomers closer to finding more worlds in the habitable 'Goldilocks zone'
Found thanks to new method pioneered by University of Warwick team designed to spot planets orbiting further out from their star
NGTS-11b is among hundreds of 'lost' worlds that can now be rediscovered with the NGTS telescopes using this novel technique
The rediscovery of a lost planet could pave the way for the detection of a world within the habitable 'Goldilocks zone' in a distant solar system.
Researchers from the Department of Computer Architecture and Technology at the University of Seville's School of Computer Engineering (ETSII) are working on a system that uses X-ray images of patients' lungs to help diagnose COVID-19. This system uses deep learning to train a neural network model that can distinguish between healthy patients, pneumonia patients and COVID-19 patients. This has been achieved using a freely accessible online database that medical professionals from around the world have been feeding with lung X-rays since the onset of the pandemic.
DNA methylation (*1) performs an essential function in mammalian ontogeny. It is also known that abnormalities in this process cause the development of cancers such as leukemia.
A research team working at The University of Tokyo and Kyoto University in Japan has announced that they have successfully identified specific target sites for the DNA methylases DNMT3A and DNMT3B (*2 ).
The researchers also found that DNMT3A specifically regulates differentiation-related genes and DNMT3B specifically regulates X-chromosomal genes during mammalian ontogeny.
Lego could be used as a practical tool to train doctors in anaesthetic skills according to new research that has shown a simple task using the building bricks can help improve technical skills - a finding that could improve medical training and patient safety.
A new study (Budhagatapalli et al., 2020), which has recently been published in the Plant Biotechnology Journal, demonstrates how site-directed mutagenesis can be achieved in virtually any wheat germplasm of choice by intergeneric pollination of wheat with cas9/guide-RNA (gRNA)-transgenic maize.
For exemplification of this principle, new allelic variants were generated for the wheat genes BRASSINOSTEROID-INSENSITIVE 1 (BRI1) and SEMIDWARF 1 (SD1) which are involved in the regulation of the agronomically important trait plant height.
New Orleans, LA - A series of autopsies conducted by LSU Health New Orleans pathologists shows the damage to the hearts of COVID-19 patients is not the expected typical inflammation of the heart muscle associated with myocarditis, but rather a unique pattern of cell death in scattered individual heart muscle cells. They report the findings of a detailed study of hearts from 22 deaths confirmed due to COVID-19 in a Research Letter published in Circulation, available here.
(Boston)--In an attempt to address the escalating rate of self-inflicted firearm injury deaths in rural America, researchers are proposing interventions to reduce these suicides be community-based and include programs to reduce other diseases of despair, such as heart and liver diseases, diabetes and accidental opioid overdose. The recent decline in life expectancy of Americans has been attributed to these diseases of despair and appear to primarily afflict white rural America.
WASHINGTON (July 21, 2020) - Nitric oxide treatment can be pivotal in the world's fight against SARS-CoV-2, the coronavirus that causes COVID-19, according to a review from the George Washington University (GW). The article is published in the journal Nitric Oxide.
In immune-related disorders, therapy often involves identifying the molecules responsible for immune dysregulation and targeting them using drugs. This type of immune therapy is also used for cancer treatment, owing to the important role that immune cells play in cancer progression. One such type of a potential therapeutic target is an "immune checkpoint" protein called PD-L2, which is specifically expressed in immune cells called dendritic cells (DCs) and macrophages.
Scientists have revealed a key factor that influences whether malignant cells will grow to form a tumour, in a new study published today in eLife.
The research combined the use of mouse breast mini-organs with continuous imaging at single-cell resolution to reveal how a tumour becomes established. The results provide insights into the behaviour of individual breast cancer cells that could lead to new strategies on how to handle the disease.