Culture
COLUMBUS, Ohio - A new deep-learning model that can predict how human genes and medicines will interact has identified at least 10 compounds that may hold promise as treatments for COVID-19.
All but two of the drugs are still considered investigational and are being tested for effectiveness against hepatitis C, fungal disease, cancer and heart disease. The list also includes the approved drugs cyclosporine, an immunosuppressant that prevents transplant organ rejection, and anidulafungin, an antifungal agent.
Over the past century, a wide variety of models have emerged to explain the complex behaviours which unfold within atomic nuclei at low energies. However, these theories bring up deep philosophical questions regarding their scientific value. Indeed, traditional epistemological tools have been rather elaborated to account for a unified and stabilised theory rather than to apprehend a plurality of models. Ideally, a theory is meant to be reductionist, unifying and fundamentalist.
Theoretical physicists of the PRISMA+ Cluster of Excellence at Johannes Gutenberg University Mainz are working on a theory that goes beyond the Standard Model of particle physics and can answer questions where the Standard Model has to pass - for example, with respect to the hierarchies of the masses of elementary particles or the existence of dark matter. The central element of the theory is an extra dimension in spacetime. Until now, scientists have faced the problem that the predictions of their theory could not be tested experimentally.
Decoy protein intercepts spike of coronavirus
Virus prevented from infecting human cells
Protein may be new way to treat and prevent COVID-19
CHICAGO --- Northwestern Medicine scientists have developed a new protein that acts as a trickster to neutralize the COVID-19 infection in a human kidney organoid, a miniature organ made from stem cells in the lab.
Social media is increasingly used to spread fake news. The same problem can be found on the capital market - criminals spread fake news about companies in order to manipulate share prices. Researchers at the Universities of Göttingen and Frankfurt and the Jožef Stefan Institute in Ljubljana have developed an approach that can recognise such fake news, even when the news contents are repeatedly adapted. The results of the study were published in the Journal of the Association for Information Systems.
The adoption of recommended changes in concussion management led to a reduction in the length of symptoms among 11- to 18-year-old athletes with first-time, sports-related concussions, according to new research in the Journal of Osteopathic Medicine. These outcomes support the widespread adoption of the updated concussion guidelines.
NEW YORK, NY (Feb. 1, 2021)--Errors in the way chromosomes are packed into antibody-producing B cells appear to play a role in the development of B cell-related blood cancers, according to a new study by researchers at Columbia University Vagelos College of Physicians and Surgeons.
The findings could lead to new biomarkers for predicting the onset of these cancers and to a new class of cancer therapies that prevent or correct harmful changes in genome architecture.
The study was published online Feb. 1 in the journal Nature Genetics.
Winter survival of honey bee colonies is strongly influenced by summer temperatures and precipitation in the prior year, according to Penn State researchers, who said their findings suggest that honey bees have a "goldilocks" preferred range of summer conditions outside of which their probability of surviving the winter falls.
Toxin-antitoxin (TA) systems are now known to negatively control plasmid replication, according to Thomas Wood, Biotechnology Endowed Chair and professor of chemical engineering in the Penn State College of Engineering.
Plasmids, or extra-chromosomal bits of DNA, allow bacteria to evade antibiotics, making the antibiotics ineffective in halting a bacterial infection.
The presence or absence of plasmids impacts a bacterium's resistance to antibiotics and its ability to cause infection -- important points related to fighting bacterial infections, according to Wood.
Imagine a rubber band that was capable of snapping itself many times over, or a small robot that could jump up a set of stairs propelled by nothing more than its own energy. Researchers at the University of Massachusetts Amherst have discovered how to make materials that snap and reset themselves, only relying upon energy flow from their environment. The discovery may prove useful for various industries that want to source movement sustainably, from toys to robotics, and is expected to further inform our understanding of how the natural world fuels some types of movement.
Obesity and its duration are significant risk factors for type 2 diabetes, cardiovascular events, multiple cancers and decreased quality of life. According to the Centers for Disease Control and Prevention, obesity affects 20.6% of adolescents ages 12-19 in the United States, meaning a potential lifetime of dealing with this condition. Complications from obesity can also result in a potentially decreased life expectancy of five to 20 years for these youth.
Risk for a severe form of retinopathy of prematurity, which can cause blindness in extremely premature babies, was halved when the newborns were given a new supplement combining various fatty acids. This was shown in a Swedish study led from the University of Gothenburg.
Astronomers from the ARC Centre of Excellence for Gravitational Wave Discovery (OzGrav) and CSIRO have just observed bizarre, never-seen-before behaviour from a 'radio-loud' magnetar--a rare type of neutron star and one of the strongest magnets in the Universe.
Their new findings, published today in the Monthly Notices of the Royal Astronomical Society (MNRAS), suggest magnetars have more complex magnetic fields than previously thought - which may challenge theories of how they are born and evolve over time.
Oak Brook, IL - The February edition of SLAS Discovery is a Special Issue on Hit Discovery Methodologies edited by Mark Wigglesworth, Ph.D., (Medicines Discovery Catapult, Stockport, EN, UK) and Peter Hodder, Ph.D. (Amgen, Thousand Oaks, CA, USA).
The focus of this Special Issue is to highlight the use of hit discovery methodologies and technologies and their usage in both small molecule and large molecule drug discovery. The February issue exemplifies how technologies, both new and existing, have been applied successfully to find hits.
The complex mechanics determining how galaxies spin, grow, cluster and die have been revealed following the release of all the data gathered during a massive seven-year Australian-led astronomy research project.
The scientists observed 13 galaxies at a time, building to a total of 3068, using a custom-built instrument called the Sydney-AAO Multi-Object Integral-Field Spectrograph (SAMI), connected to the 4-metre Anglo-Australian Telescope (AAT) at Siding Spring Observatory in New South Wales. The telescope is operated by the Australian National University.