Culture
Researchers at Karolinska Institutet in Sweden have developed, in collaboration with researchers in Germany and the U.S., new small antibodies, also known as nanobodies, which prevent the SARS-CoV-2 coronavirus from entering human cells. The research study, published in Science, shows that a combined nanobody had a particularly good effect - even if the virus mutated. According to the researchers, the nanobodies have the potential to be developed into a treatment for COVID-19.
An immunization strategy tested in mice protects against infection from SARS-CoV-2, as well as from potentially emerging animal coronaviruses, researchers say. The approach could be "used as described or easily adapted" to provide defense against newly discovered zoonotic coronaviruses. In the last 20 years, three betacoronaviruses have caused devastating disease in humans. The global pandemic caused by the latest such virus, SARS-CoV-2, highlights the need to protect against other strains that could present a threat to humans, possibly through a pan-coronavirus vaccine.
It's been more than a year since the first cases were identified in China, yet the exact origins of the COVID-19 pandemic remain a mystery. Though strong evidence suggests that the responsible coronavirus originated in bats, how and when it crossed from wildlife into humans is unknown.
In a study published online Jan.12 in the journal mBio, an international team of 15 biologists say this lack of clarity has exposed a glaring weakness in the current approach to pandemic surveillance and response worldwide.
Exercising regularly is one of the best defences against metabolic diseases, such as obesity and diabetes - but why? It's a question that scientists are still struggling to answer. While exercising changes the molecular behaviour of muscles, it's not well understood how these molecular changes improve metabolic health.
BOSTON -- By mid-November, the Centers for Disease Control and Prevention had reported that 218,439 health care workers in the U.S. had been infected with COVID-19 -- a likely underestimate due to incomplete data from states. About 3% to 4% of health care personnel who recover from coronavirus infection are expected to become "COVID long-haulers" as they cope with debilitating symptoms 12 to 18 months after the acute stage of the infection clears.
A study of students at seven public universities across the United States has identified risk factors that may place students at higher risk for negative psychological impacts related to the COVID-19 pandemic. Factors associated with greater risk of negative impacts include the amount of time students spend on screens each day, their gender, age and other characteristics.
PHILADELPHIA -- (Jan. 12, 2021) -- Scientists at The Wistar Institute have created an advanced humanized immune system mouse model that allows them to examine resistance to immune checkpoint blockade therapies in melanoma. It has revealed a central role for mast cells. These findings were published today in the journal Nature Communications.
Checkpoint inhibitors revolutionized therapeutic options for advanced melanoma. However, only a fraction of patients respond to this treatment and some relapse due to reemergence of therapy-resistant lesions.
Gut microbes passed from female mice to their offspring, or shared between mice that live together, may influence the animals' bone mass, says a new study published today in eLife.
The findings suggest that treatments which alter the gut microbiome could help improve bone structure or treat conditions that weaken bones, such as osteoporosis.
Using both mouse and human brain tissue, researchers at Yale School of Medicine have discovered that SARS-CoV-2 can directly infect the central nervous system and have begun to unravel some of the virus’s effects on brain cells. The study, published today in the Journal of Experimental Medicine (JEM), may help researchers develop treatments for the various neurological symptoms associated with COVID-19.
Almost 18,000 Americans experience traumatic spinal cord injuries every year. Many of these people are unable to use their hands and arms and can't do everyday tasks such as eating, grooming or drinking water without help.
A recent study finds that, in the wake of a mass shooting, National Rifle Association (NRA) employees, donors and volunteers had extremely mixed emotions about the organization - reporting higher levels of both positive and negative feelings about the NRA, as compared to people with no NRA affiliation.
WASHINGTON -- Researchers have developed a new laser-based process for 3D printing intricate parts made of glass. With further development, the new method could be useful for making complex optics for vision, imaging, illumination or laser-based applications.
"Most 3D printing processes build up an object layer by layer," said research team leader Laurent Gallais from The Fresnel Institute and Ecole Centrale Marseille in France. "Our new process avoids the limitations of these processes by using a laser beam to transform -- or polymerize -- a liquid precursor into solid glass."
One-third of the fertilizer applied to grow corn in the U.S. each year simply compensates for the ongoing loss of soil fertility, leading to more than a half-billion dollars in extra costs to U.S. farmers every year, finds new research from the University of Colorado Boulder published last month in Earth's Future.
Every field has its underlying principles. For economics it's the rational actor; biology has the theory of evolution; modern geology rests on the bedrock of plate tectonics.
Physics has conservation laws and symmetries. For instance, the law of conservation of energy - which holds that energy can neither be created nor destroyed -- has guided research in physics since antiquity, becoming more formalized as time went on. Likewise, parity symmetry suggests that switching an event for its mirror image shouldn't affect the outcome.
Most flowering plants depend on pollinators such as bees to transfer pollen from the male anthers of one flower to the female stigma of another flower, enabling fertilization and the production of fruits and seeds. Bee pollination, however, involves an inherent conflict of interest, because bees are only interested in pollen as a food source.