image: Cover image of March SLAS Discovery
Oak Brook, IL - The March edition of SLAS Discovery features the cover article, "CRISPR: A Screener's Guide," by Carlos le Sage, Ph.D., Steffen Lawo, Ph.D., and Benedict C.S. Cross, Ph.D., (Horizon Discovery, United Kingdom). In their review, the authors discuss how CRISPR-Cas9 systems are being used widely throughout the drug discovery process and the development of new precision medicines.
The discovery of CRISPR-Cas9 systems has helped ignite gene editing adoption and has greatly impacted pharmaceutical and biotechnology research. Because of the CRISPR-Cas9 discovery, gene editing can be used at an industrial scale to identify and validate new biological targets for precision medicines, with functional genomic screening also having an increasingly important role. CRISPR screens provide more robust data sets for target identification and validation, and identify potential mechanisms of drug resistance and sensitivity ahead of new drugs entering clinical trials.
The March cover article also examines the developing landscape for CRISPR screening technologies within the pharmaceutical industry and explores the next steps for this constantly evolving screening platform.