NEW YORK, NY (April 20, 2014) — A team of researchers from Columbia University Medical Center (CUMC), Weill Cornell Medical College, and Brandeis University has devised a wholly new approach to the treatment of Alzheimer's disease involving the so-called retromer protein complex. Retromer plays a vital role in neurons, steering amyloid precursor protein (APP) away from a region of the cell where APP is cleaved, creating the potentially toxic byproduct amyloid-beta, which is thought to contribute to the development of Alzheimer's.
Brain
Harvard neuroscientists have made a discovery that turns 160 years of neuroanatomy on its head.
Myelin, the electrical insulating material long known to be essential for the fast transmission of impulses along the axons of nerve cells, is not as ubiquitous as thought, according to a new work lead by Professor Paola Arlotta of the Harvard Stem Cell Institute (HSCI) and the University's Department of Stem Cell and Regenerative Biology, in collaboration with Professor Jeff Lichtman, of Harvard's Department of Molecular and Cellular Biology.
What's one of your worst memories? How did it make you feel? According to psychologists, remembering the emotions felt during a negative personal experience, such as how sad you were or how embarrassed you felt, can lead to emotional distress, especially when you can't stop thinking about it.
When these negative memories creep up, thinking about the context of the memories, rather than how you felt, is a relatively easy and effective way to alleviate the negative effects of these memories, a new study suggests.
Two Simon Fraser University psychologists have made a brain-related discovery that could revolutionize doctors' perception and treatment of attention-deficit disorders.
This discovery opens up the possibility that environmental and/or genetic factors may hinder or suppress a specific brain activity that the researchers have identified as helping us prevent distraction.
The negative social, physical and mental health effects of childhood bullying are still evident nearly 40 years later, according to new research by King's College London. The study is the first to look at the effects of bullying beyond early adulthood, and is published in the American Journal of Psychiatry.
A groundbreaking study published in PLOS ONE by Prof. Iris Berent of Northeastern University and researchers at Harvard Medical School shows the brains of individual speakers are sensitive to language universals. Syllables that are frequent across languages are recognized more readily than infrequent syllables. Simply put, this study shows that language universals are hardwired in the human brain.
LANGUAGE UNIVERSALS
Researchers at the University of California, San Diego School of Medicine report that older women, plucky individuals and those who have suffered a recent major loss are more likely to be compassionate toward strangers than other older adults.
The study is published in this month's issue of the International Journal of Geriatric Psychiatry.
April 17, 2014 - Easter is a time when many people in the world think about their relationships with God. New research explores a little-understood role of God in people's lives: helping them cope with the threat of romantic rejection. In this way, God stands in for other relationships in our lives when times are tough.
NEW YORK, NY (April 16, 2014) — The cause of neuronal death in Parkinson's disease is still unknown, but a new study proposes that neurons may be mistaken for foreign invaders and killed by the person's own immune system, similar to the way autoimmune diseases like type I diabetes, celiac disease, and multiple sclerosis attack the body's cells. The study was published April 16, 2014, in Nature Communications.
New York, NY – A new study points to a conceptually novel therapeutic strategy for treating depression. Instead of dampening neuron firing found with stress-induced depression, researchers demonstrated for the first time that further activating these neurons opens a new avenue to mimic and promote natural resilience. The findings were so surprising that the research team thinks it may lead to novel targets for naturally acting antidepressants. Results from the study are published online April 18 in the journal Science.
PHILADELPHIA - Mom always said you need your sleep, and it turns out, she was right. According to a new study published in Science this week from researchers at the Perelman School of Medicine at the University of Pennsylvania, lack of sleep in young fruit flies profoundly diminishes their ability to do one thing they do really, really well – make more flies.
Scientists have traced vulnerability to depression-like behaviors in mice to out-of-balance electrical activity inside neurons of the brain's reward circuit and experimentally reversed it – but there's a twist.
Instead of suppressing it, researchers funded by the National Institutes of Health boosted runaway neuronal activity even further, eventually triggering a compensatory self-stabilizing response. Once electrical balance was restored, previously susceptible animals were no longer prone to becoming withdrawn, anxious, and listless following socially stressful experiences.
Researchers at The Sainsbury Laboratory (TSL), Norwich, collaborating with structural biologist Bostjan Kobe in Brisbane, have made a major advance in understanding plant disease resistance.
"Before, we knew that proteins called RRS1 and RPS4 are required to recognize specific molecules from pathogenic bacteria, and then use this recognition as a cue to activate defence. However, we had no idea how they did it," says co-corresponding author Jonathan Jones of TSL.
Adolescent drivers are often distracted by technology while they are driving, but loud conversations and horseplay between passengers appear more likely to result in a dangerous incident, according to a new study from the UNC Highway Safety Research Center.
The work, which appears online today in the Journal of Adolescent Health, not only reinforces the importance of North Carolina's licensing system for newly minted drivers but also provides an interesting perspective on the role that technology plays in distracted driving.
New Rochelle, NY, April 17, 2014—U.S. military personnel who served in Iraq and Afghanistan and suffered "blast plus impact" concussive traumatic brain injury (TBI) were compared to military personnel without TBI who were evacuated for other medical reasons. Differences in measures of overall disability, cognitive function, post-traumatic stress, and depression 6-12 months after injury are reported in an article in Journal of Neurotrauma, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.