New simple and effective methods are needed to better evaluate the outcomes of repair using nerve conduits in vivo. Ultrasound is a common noninvasive clinical detection modality that has been used in many fields. However, ultrasound has only rarely been used to observe implanted nerve conduits in vivo. Hongkui Wang and co-workers from Affiliated Hospital of Nantong University report the first use of ultrasound to noninvasively observe the changes in chitosan nerve conduits implanted in rats over time.
Brain
Platelet-rich plasma (PRP) containing various growth factors can promote nerve regeneration. An inside-out vein graft can substitute nerve autograft to repair short nerve defects. It is hypothesized that an inside-out vein graft filled with platelet-rich plasma shows better effects in the repair of short sciatic nerve defects. In a study reported on the Neural Regeneration Research (Vol. 9, No. 14, 2014), an inside-out vein autograft filled with platelet-rich plasma was used to bridge a 10 mm-long sciatic nerve defect in rats.
Barcelona, 18 August 2014. Research led by the Vall d'Hebron Institute of Oncology (VHIO) evidence the most conclusive preclinical results to-date validating Myc inhibition as a therapeutic strategy in glioma – a highly agressive tumor type that notoriously outsmarts current anti-cancer therapies.
Optic nerve transection increased the expression of heat shock protein 72 (HSP72) in the lateral geniculate body, indicating that this protein is involved in the prevention of neuronal injury. Zinc sulfate and quercetin induced and inhibited the expression of HSP72, respectively. In a study reported by Dr.
Oxidative stress may cause retinal pigment epithelial (RPE) cell apoptosis. Nitric oxide and superoxide react to produce peroxynitrite, which, along with its derivatives, are strong oxidants. Cholecystokinin octapeptide-8 (CCK-8) can protect cholinergic neurons against basal forebrain lesion caused by brain injury. Research team at Hebei Province People's Hospital, China led by Dr. Yuan Liu treated human RPE cells with the oxidative stress inducer peroxynitrite, and evaluated the neuroprotective effects of CCK-8.
Boston, MA – A new study led by researchers at Brigham and Women's Hospital (BWH) and Rush University Medical Center, reveals how early changes in brain DNA methylation are involved in Alzheimer's disease. DNA methylation is a biochemical alteration of the building blocks of DNA and is one of the markers that indicate whether the DNA is open and biologically active in a given region of the human genome.
The study is published online August 17, 2014 in Nature Neuroscience.
A team led by researchers at the University of Exeter Medical School and King's College London has uncovered some of the strongest evidence yet that epigenetic changes in the brain play a role in Alzheimer's disease.
Epigenetic changes affect the expression or activity of genes without changing the underlying DNA sequence and are believed to be one mechanism by which the environment can interact with the genome. Importantly, epigenetic changes are potentially reversible and may therefore provide targets for the development of new therapies.
One difficulty in studying the genetics of common mental illnesses is that they are generally caused by environmental factors in combination with multiple gene variants, any one of which usually could not by itself cause disease. A rare exception is the gene known as disrupted in schizophrenia 1 (DISC1), in which some mutations have a strong effect. Two families have been found in which many members with the DISC1 mutations have mental illness.
As children learn basic arithmetic, they gradually switch from solving problems by counting on their fingers to pulling facts from memory. The shift comes more easily for some kids than for others, but no one knows why.
Researchers have long suspected that major mental disorders are genetically-rooted diseases of synapses – the connections between neurons. Now, investigators supported in part by the National Institutes of Health have demonstrated in patients' cells how a rare mutation in a suspect gene disrupts the turning on and off of dozens of other genes underlying these connections.
People with schizophrenia struggle to turn goals into actions because brain structures governing desire and emotion are less active and fail to pass goal-directed messages to cortical regions affecting human decision-making, new research reveals.
Published in Biological Psychiatry, the finding by a University of Sydney research team is the first to illustrate the inability to initiate goal-directed behaviour common in people with schizophrenia.
Magpies are not attracted to shiny objects and don't routinely steal small trinkets such as jewellery, according to a new study.
In European culture, it is widely accepted that magpies (Pica pica) are the pilferers of the bird kingdom, unconditionally attracted to sparkly things and prone to pinching them for their nests, almost as a compulsion.
Shortly after actor Robin Williams committed suicide, his wife revealed he had the early stages of Parkinson's disease and some immediately began to link that to 'life is not worth living'. Depression is known to be a common symptom of Parkinson's disease, but remains untreated for many patients, according to a new study by Northwestern Medicine investigators in collaboration with the National Parkinson's Foundation (NPF).
Following another person's gaze can reveal a wealth of information critical to social interactions and also to safety. Gaze following typically emerges in infancy, and new research looking at preterm infants suggests that it's visual experience, not maturational age, that underlies this critical ability.
The research is published in Psychological Science, a journal of the Association for Psychological Science.
Tissue engineering technologies offer new treatment strategies for the repair of peripheral nerve injury, but cell loss between seeding and adhesion to the scaffold remains inevitable. In a study reported on the Neural Regeneration Research (Vol. 9, No.