Heat shock protein (HSP90) has been suggested to be involved in neuronal protein misfolding and accumulation in Parkinson's disease (PD) brains leading to dopaminergic neuronal death and the eventual dopamine depletion. Therefore, HSP90 has been suggested as a therapeutic target in PD. Dr. Muhammed Al-Jarrah and co-workers from Jordan University of Science and Technology (JUST) point out exercise training significantly inhibited HSP90 overexpression in the soleus and gastrocnemius in PDe rats, which is a potential therapeutic target for ameliorating skeletal muscle abnormalities in PD.
Brain
Continuous positive airway pressure is effective at treating sleep apnoea in older people, a new study has found.
Obstructive sleep apnoea (OSA) is a condition where the walls of the throat relax and narrow during sleep, interrupting normal breathing and causing profound sleepiness. For people with moderate or severe OSA, doctors usually recommend using a continuous positive airway pressure (CPAP) device, which consists of a small pump that delivers pressurised air into the nose through a mask, stopping the throat from closing.
HOUSTON – (Aug. 26, 2014) – Binge eating, an eating disorder in which a person frequently consumes unusually large amounts of food in a short period of time, affects about 5 to 10 percent of U.S. adults and is more common in women than men. Researchers at the USDA/ARS Children's Nutrition Research Center at Baylor College of Medicine and Texas Children's Hospital found that the hormone estrogen can specifically trigger brain serotonin neurons to inhibit binge eating in female mice in a report today in the Journal of Clinical Investigation.
Fever is a response to inflammation, and is triggered by an onset of the signaling substance prostaglandin. Researchers at Linköping University in Sweden can now see precisely where these substances are produced – a discovery that paves the way for smarter drugs.
When you take an aspirin, all production of prostaglandins in the body is suppressed. All symptoms of inflammation are eased simultaneously, including fever, pain and loss of appetite. But it might not always be desirable to get rid of all symptoms – there is a reason why they appear.
- A new study examines antecedent predictors of childhood initiation of sipping or tasting alcohol.
- Findings indicate that initiation of sipping/tasting was less related to psychosocial proneness for problem behavior and more related to perceived parental approval for child sipping.
High-dose erythropoietin (EPO; a hormone) administered within 42 hours of birth to preterm infants was associated with a reduced risk of brain injury, as indicated by magnetic resonance imaging, according to a study in the August 27 issue of JAMA.
Premature babies are far more at risk than infants born at term of developing brain damage resulting in neurodevelopmental delay that may persist throughout their lives. A team of specialists in infant brain imaging from the Faculty of Medicine at the University of Geneva (UNIGE) and the University Hospital of Geneva (HUG) has demonstrated the following: administering three doses of erythropoietin – a hormone that stimulates the formation of red blood cells – immediately after birth significantly reduces brain damage in babies.
PHILADELPHIA — Treating the rare disease MPS I is a challenge. MPS I, caused by the deficiency of a key enzyme called IDUA, eventually leads to the abnormal accumulation of certain molecules and cell death.
Argonne, Ill.– Scientists succeeded in obtaining an unprecedented view of a type of brain-cell receptor that is implicated in a range of neurological illnesses, including Alzheimer's disease, Parkinson's disease, depression, schizophrenia, autism, and ischemic injuries associated with stroke.
Scientists at the University of Warwick have provided the first evidence that the lack of a naturally occurring protein is linked to early signs of dementia.
Published in Nature Communications, the research found that the absence of the protein MK2/3 promotes structural and physiological changes to cells in the nervous system. These changes were shown to have a significant correlation with early signs of dementia, including restricted learning and memory formation capabilities.
Washington, DC—Weight loss surgery can curb alterations in brain activity associated with obesity and improve cognitive function involved in planning, strategizing and organizing, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).
Obesity can tax the brain as well as other organs. Obese individuals face a 35 percent higher risk of developing Alzheimer's disease compared to normal weight people.
Philadelphia, Aug. 25, 2014 – Reporting on 100 recent cases of fetal surgery for spina bifida, specialists at a premier fetal surgery program achieved results similar to those published three years previously in a landmark clinical trial that established a new standard of care for prenatal repair of this birth defect.
BUFFALO, N.Y. – New research findings from a study of 634 couples found that the more often they smoked marijuana, the less likely they were to engage in domestic violence.
The study, conducted by researchers in the University at Buffalo School of Public Health and Health Professions and Research Institute on Addictions (RIA), appeared in the online edition of Psychology of Addictive Behaviors in August.
Scientists from the University of Liverpool have demonstrated the effectiveness of a fibre-based dietary ingredient that makes people feel less hungry and consume less food.
Previous studies that have suggested an increased risk of autism among children of women who took antidepressants during pregnancy may actually reflect the known increased risk associated with severe maternal depression.